Mus musculus L. (mouse) [MMU]

FULL NAME: Probable crossover junction endonuclease EME2


DESCRIPTION:
Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures (By similarity).

STRUCTURE SIMILARITY:
Belongs to the EME1/MMS4 family.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MAEVGPGRVT VSRLGRGLRL GHRRPQTWEI SDSDGEGVPA REVGTQAPSP AGERRAAAKA
        70         80         90        100        110        120
LRADQVLGRL VVCVDPAVLE DAGSDILMEA LGTLGCECRI EPQHQARSLQ WNVVRPDPAP
       130        140        150        160        170        180
SNVPLEAKAE NEQEQLLLLE PQEFLQGAAQ LTQITDPPCS IPWLSPKSLT RSHLAVIGLD
       190        200        210        220        230        240
AYLWSHQLSS QKTWQLKKSK EAHARGAISW AEVEEILVLL QLHANLDVLL MASWQELSQY
       250        260        270        280        290        300
VCAFTRALSQ LPSKQHRDSQ AFSFCTAGHW ASGQQVTRDG SGLRGVWWRQ IRQFNRVSPA
       310        320        330        340        350        360
VADAVVTAFP SPRLLQQALL DCSTEQERLS LLADLPVKAH KGKQPRRVGP DLSRRICIFL
       370
TTTNPDLLLD LSS    

Encoded by Eme2 gene

FULL NAME: essential meiotic endonuclease 1 homolog 2 (S. pombe)


OTHER NAME(S):
2810013J18Rik


Nucleic acid sequence

        10         20         30         40         50         60
atggcggagg ttggtcccgg gagagtcacg gtctcgcgtc tcggtcgggg cctgcgtctc
        70         80         90        100        110        120
ggccatcggc gacctcaaac ctgggagatt tccgactcag acggtgaagg tgtccccgct
       130        140        150        160        170        180
agggaggtcg gcacgcaagc cccgagtcca gcaggagagc gcagagctgc agccaaggct
       190        200        210        220        230        240
ttacgggcag atcaggttct ggggcgactg gtggtgtgcg tggacccagc tgtcctggaa
       250        260        270        280        290        300
gatgcaggct ctgacatcct gatggaggcg ctgggcacgc taggctgtga atgccgcatc
       310        320        330        340        350        360
gaaccgcagc accaggcccg cagcctgcag tggaacgttg tcaggcccga cccggccccc
       370        380        390        400        410        420
agcaatgtgc ctctggaggc gaaggctgaa aatgagcagg aacagttgct gctgctggaa
       430        440        450        460        470        480
ccccaggaat ttcttcaggg tgctgcgcag ctgacccaga tcacagatcc accttgctcc
       490        500        510        520        530        540
atcccctggc tttctcccaa gagtctcacc cgctcccatc tggctgtcat tggactggac
       550        560        570        580        590        600
gcatacctgt ggtctcacca gctcagttct cagaagacat ggcaactaaa gaagtcaaag
       610        620        630        640        650        660
gaagcccatg ccaggggagc catcagctgg gctgaggtgg aggagatcct ggtgctgctg
       670        680        690        700        710        720
cagctccatg caaacctgga tgtgctgctg atggcttcgt ggcaggagct gagtcagtac
       730        740        750        760        770        780
gtgtgtgcct tcaccagggc cctctcgcag ctcccctcga agcagcaccg ggactcccag
       790        800        810        820        830        840
gccttttctt tctgcacagc agggcactgg gcctcaggcc agcaagtgac cagagatggc
       850        860        870        880        890        900
tctgggctca gaggagtgtg gtggcgacaa atcagacagt tcaaccgggt cagcccagct
       910        920        930        940        950        960
gtggctgacg ctgttgttac tgccttccca tcaccccgcc ttttgcaaca ggctctcctg
       970        980        990       1000       1010       1020
gactgcagca cagagcaaga acgcctgagc ctcctagctg atctccctgt gaaggcccac
      1030       1040       1050       1060       1070       1080
aaaggcaagc agcctcgcag agtggggcct gacctctcac gcagaatctg tatcttcttg
      1090       1100       1110       1120
acaaccacca accctgacct cctgctggac ctgagctctt ga 

Last modification date: Oct. 2, 2011