Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: Probable endonuclease III homolog


DESCRIPTION:
Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Primarily excises oxidized pyrimidine bases.

STRUCTURE SIMILARITY:
Belongs to the Nth/MutY family.
Contains 1 HhH domain.


CATALYTIC ACTIVITY:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MRKDMIAPVD TMGCHKLADP LAAPPVHRFQ VLVALMLSSQ TRDEVNAAAM KRLKDHGLSI
        70         80         90        100        110        120
GKILEFKVPD LETILCPVGF YKRKAVYLQK TAKILKDDFS GDIPDSLDGL CALPGVGPKM
       130        140        150        160        170        180
ANLVMQIAWG ECVGIAVDTH VHRISNRLGW IKTSTPEKTQ KALEILLPKS EWQPINHLLV
       190        200        210        220        230        240
GFGQMQCQPV RPKCGTCLCR FTCPSSTAKN VKSETEETST SIEVKQEVED EFEDEKPAKK
       250
IKKTRKTRTK IEVKTESET    

Encoded by nth-1 gene

FULL NAME: NTH (eNdonuclease THree like) homolog


Nucleic acid sequence

        10         20         30         40         50         60
atgagaaagg atatgattgc acctgtggat acgatgggat gtcataagct tgcagatcct
        70         80         90        100        110        120
ttggcagctc cgccggttca tcgatttcaa gttcttgttg ccctgatgct ttccagtcaa
       130        140        150        160        170        180
accagagatg aagtcaatgc ggcggcgatg aaaagactca aggatcatgg cttgtcaatc
       190        200        210        220        230        240
gggaaaattc tcgaattcaa agtaccagac ttggagacga ttttgtgtcc tgttggattt
       250        260        270        280        290        300
tataaaagaa aggccgtgta ccttcaaaag actgcaaaaa ttctgaaaga tgatttttct
       310        320        330        340        350        360
ggcgatatcc ctgattccct ggacggactg tgcgcactgc caggagttgg cccaaaaatg
       370        380        390        400        410        420
gcgaatctcg tcatgcaaat tgcttgggga gaatgtgtgg gaattgcagt cgacacacat
       430        440        450        460        470        480
gttcacagaa tttctaatcg actcggctgg atcaagacca gcaccccaga aaagacacaa
       490        500        510        520        530        540
aaagcgcttg aaattctact tccaaagtcg gaatggcaac caattaatca tcttctcgtt
       550        560        570        580        590        600
ggattcggtc agatgcaatg ccaaccagtt cgtccgaaat gtggaacttg tctctgtaga
       610        620        630        640        650        660
tttacgtgcc ccagttccac agctaaaaat gtgaagagcg agactgaaga gacttccaca
       670        680        690        700        710        720
agtatcgagg ttaaacaaga agttgaggat gaatttgaag atgaaaaacc tgcgaaaaag
       730        740        750        760        770        780
attaagaaaa ccagaaaaac tagaaccaag attgaagtga aaactgaatc ggaaacgtag

Last modification date: Oct. 2, 2011