Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: A/G-specific adenine DNA glycosylase


DESCRIPTION:
Adenine glycosylase active on G-A mispairs. Has glycosylase and nicking activities and is active at A/G and A/GO sites.

STRUCTURE SIMILARITY:
Belongs to the Nth/MutY family.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MSDSNHSLDL HSYTQLEVER FRESLIQFYD KTKRILPWRK KECIPPSEDS PLEDWEQPVQ
        70         80         90        100        110        120
RLYEVLVSEI MLQQTRVETV KRYYTKWMET LPTLKSCAEA EYNTQVMPLW SGMGFYTRCK
       130        140        150        160        170        180
RLHQACQHLA KLHPSEIPRT GDEWAKGIPG VGPYTAGAVL SIAWKQPTGI VDGNVIRVLS
       190        200        210        220        230        240
RALAIHSDCS KGKANALIWK LANELVDPVR PGDFNQALME LGAITCTPQS PRCSVCPISE
       250        260        270        280        290        300
ICKAYQEQNV IRDGNTIKYD IEDVPCNICI TDIPSKEDLQ NWVVARYPVH PAKTKQREER
       310        320        330        340        350        360
ALVVIFQKTD PSTKEKFFLI RKRPSAGLLA GLWDFPTIEF GQESWPKDMD AEFQKSIAQW
       370        380        390        400        410        420
ISNDSRSLIK KYQSRGRYLH IFSHIRKTSH VFYAIASPDI VTNEDFFWIS QSDLEHVGMC
       430        440        450        460
ELGLKNYRAA LEIKKRKVTS LSNFKEPKLT SARRIVTKAE C 

Encoded by myh1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtcggatt caaatcattc tttagatttg cattcctaca cacaactaga agtagaaagg
        70         80         90        100        110        120
tttcgcgaga gtttgattca attctacgat aaaactaaaa ggattttacc ttggagaaaa
       130        140        150        160        170        180
aaagaatgta ttcctccttc ggaagactca ccgttggaag actgggagca accagtacaa
       190        200        210        220        230        240
aggttgtatg aagtgcttgt ttcagaaatt atgctgcagc aaactcgtgt ggagacagtt
       250        260        270        280        290        300
aaacggtatt acacgaagtg gatggagact cttcctactt taaaatcatg tgctgaagca
       310        320        330        340        350        360
gagtacaaca cacaggtaat gccactgtgg tcaggaatgg gcttttacac acggtgcaaa
       370        380        390        400        410        420
cgactccatc aagcttgtca gcatcttgcc aaacttcatc ccagtgagat tcctaggacg
       430        440        450        460        470        480
ggagatgaat gggcgaaggg aattcctggt gtgggccctt atacagcagg tgctgtattg
       490        500        510        520        530        540
agtattgcat ggaaacagcc aacaggcatt gtggatggca atgtcattcg tgtattaagt
       550        560        570        580        590        600
agggctttag ctatccatag tgattgcagc aagggaaagg cgaatgcttt aatttggaag
       610        620        630        640        650        660
ctagccaatg agcttgtaga tcctgttaga cctggagatt tcaatcaggc gttaatggag
       670        680        690        700        710        720
ctaggtgcaa tcacttgtac tcctcagagt cctcgatgct cggtttgccc aatctctgaa
       730        740        750        760        770        780
atttgtaaag cataccaaga acaaaacgta atacgcgatg gaaatacgat taaatatgat
       790        800        810        820        830        840
atagaggatg taccctgtaa tatttgcatc acagatattc caagcaaaga agatttacaa
       850        860        870        880        890        900
aactgggttg ttgcgagata tccagtccat ccagctaaga caaaacaacg agaagaaagg
       910        920        930        940        950        960
gcgctcgttg ttatatttca gaaaactgat ccttctacca aagaaaagtt tttccttatc
       970        980        990       1000       1010       1020
cgaaagcgac cgagtgcagg gcttttagca gggctatggg atttcccaac aatcgagttt
      1030       1040       1050       1060       1070       1080
ggacaagaat cttggccaaa agatatggat gcggaatttc agaaatctat tgctcaatgg
      1090       1100       1110       1120       1130       1140
atatcaaatg atagccgttc tcttattaaa aagtatcaat cccgaggaag atacttacat
      1150       1160       1170       1180       1190       1200
atattcagtc acatacggaa aacaagtcac gttttttatg ctattgcttc tcccgatatt
      1210       1220       1230       1240       1250       1260
gttacgaacg aggatttctt ttggatttcg caatctgatc ttgaacatgt tggaatgtgt
      1270       1280       1290       1300       1310       1320
gaactgggat taaaaaacta tcgagcagca ttagaaataa aaaaaagaaa ggttacatct
      1330       1340       1350       1360       1370       1380
ctttcaaatt ttaaagaacc taagttgaca tcggcaagaa ggattgtaac gaaagcagag

tgctaa     

Last modification date: Oct. 2, 2011