Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Uracil-DNA glycosylase


DESCRIPTION:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

STRUCTURE SIMILARITY:
Belongs to the uracil-DNA glycosylase family.


CATALYTIC ACTIVITY:
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MTVLNTTDKR KADDTVNKLD GKLKQPRLDN FFKTNTSSPA LKDTQVLDNK ENNSVSKFNK
        70         80         90        100        110        120
EKWAENLTPA QRKLLQLEID TLESSWFDAL KDEFLKPYFL NLKEFLMKEW QSQRVFPPKE
       130        140        150        160        170        180
DIYSWSHHTP LHKTKVILLG QDPYHNIGQA HGLCFSVRPG IPCPPSLVNI YKAIKIDYPD
       190        200        210        220        230        240
FVIPKTGYLV PWADQGILML NASLTVRAHQ AASHSGKGWE TFTSAVLQVA LNRNRKGLVI
       250        260        270        280        290        300
LAWGTPAAKR LQGLPLKAHY VLRSVHPSPL SAHRGFFECH HFKKTNEWLE EQYGPEKCIN
       310        320
WSAVSEQKAK IKSSELESSS TE   

Encoded by ung1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgactgttc tgaatactac agataagcgt aaagctgatg ataccgttaa taaacttgac
        70         80         90        100        110        120
gggaaattaa agcagccacg tttggataat ttttttaaga caaacacctc atcgcctgct
       130        140        150        160        170        180
ttaaaggata ctcaggtact tgataataaa gagaacaact ctgtctcaaa gttcaataaa
       190        200        210        220        230        240
gaaaaatggg cagaaaatct tactcctgct caaagaaagc tgttacaact agaaattgat
       250        260        270        280        290        300
actttggaga gttcttggtt tgatgcgtta aaagatgaat ttttaaagcc atattttttg
       310        320        330        340        350        360
aatctgaaag agtttttgat gaaggaatgg caaagccaac gtgtattccc gccgaaagaa
       370        380        390        400        410        420
gatatctact catggtcaca tcatactcca cttcataaaa ccaaggtcat tctcttagga
       430        440        450        460        470        480
caagatcctt accataacat tggtcaagcc catggtcttt gcttttccgt acgtccagga
       490        500        510        520        530        540
attccatgtc caccaagttt ggtcaacata tataaagcca tcaagatcga ttatcctgat
       550        560        570        580        590        600
tttgttattc cgaaaacagg gtatttagtt ccttgggctg accaaggcat tttaatgctc
       610        620        630        640        650        660
aacgctagtt taactgtaag agcccatcaa gctgcttctc attctggcaa gggttgggaa
       670        680        690        700        710        720
actttcactt ctgctgtcct gcaagttgcg ttgaatcgga atcgcaaggg tcttgtaatt
       730        740        750        760        770        780
ttagcatggg gaactccagc agctaagcga cttcaaggtc ttcctttgaa agcacactat
       790        800        810        820        830        840
gtacttagaa gtgtccatcc tagccctctc tctgcacatc gtggcttttt tgaatgccac
       850        860        870        880        890        900
catttcaaga aaaccaatga gtggctcgaa gagcagtatg gacctgaaaa atgcatcaat
       910        920        930        940        950        960
tggagcgctg tttctgaaca aaaagcaaaa ataaagtcta gcgagttgga atcctcttca

actgagtag     

Last modification date: Oct. 2, 2011