Mus musculus L. (mouse) [MMU]

FULL NAME: Three prime repair exonuclease 1


DESCRIPTION:
Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair.

STRUCTURE SIMILARITY:
Belongs to the exonuclease superfamily. TREX family.


CATALYTIC ACTIVITY:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MGSQTLPHGH MQTLIFLDLE ATGLPSSRPE VTELCLLAVH RRALENTSIS QGHPPPVPRP
        70         80         90        100        110        120
PRVVDKLSLC IAPGKACSPG ASEITGLSKA ELEVQGRQRF DDNLAILLRA FLQRQPQPCC
       130        140        150        160        170        180
LVAHNGDRYD FPLLQTELAR LSTPSPLDGT FCVDSIAALK ALEQASSPSG NGSRKSYSLG
       190        200        210        220        230        240
SIYTRLYWQA PTDSHTAEGD VLTLLSICQW KPQALLQWVD EHARPFSTVK PMYGTPATTG
       250        260        270        280        290        300
TTNLRPHAAT ATTPLATANG SPSNGRSRRP KSPPPEKVPE APSQEGLLAP LSLLTLLTLA
       310
IATLYGLFLA SPGQ    

Encoded by Trex1 gene

FULL NAME: three prime repair exonuclease 1


OTHER NAME(S):
1661
AU041952


Nucleic acid sequence

        10         20         30         40         50         60
atgggctcac agaccctgcc ccatggtcac atgcagaccc tcatcttctt agacctggaa
        70         80         90        100        110        120
gccactggcc tgccttcgtc tcggcccgaa gtcacagagc tgtgcctgct ggctgtccac
       130        140        150        160        170        180
agacgtgctc tggagaacac ttccatttct cagggacatc cacctccagt gcccagaccg
       190        200        210        220        230        240
ccccgtgtgg tggacaagct ctctctgtgc attgctccag ggaaagcctg tagccctggg
       250        260        270        280        290        300
gccagtgaga tcacaggtct gagcaaagct gagctggaag tacaggggcg tcaacgcttc
       310        320        330        340        350        360
gatgacaacc tggccatcct gctccgagcc ttcctgcagc gccagccaca gccttgctgc
       370        380        390        400        410        420
cttgtggcac acaacggtga ccgctatgac tttcctctgc tccagacaga gcttgctagg
       430        440        450        460        470        480
ctgagcactc ccagtcccct agatggtacc ttctgtgtgg acagcatcgc tgccctaaag
       490        500        510        520        530        540
gccttggaac aagctagcag cccctcaggg aatggttcga ggaaaagcta cagcctgggc
       550        560        570        580        590        600
agcatctaca cccgcctgta ctggcaagca ccgacagact cacatactgc tgaaggtgat
       610        620        630        640        650        660
gttctaaccc tgctcagcat ctgtcagtgg aagccacagg ccctactgca gtgggtggac
       670        680        690        700        710        720
gaacatgccc ggccctttag caccgtcaag cccatgtacg gcactccggc taccactgga
       730        740        750        760        770        780
acaaccaacc taaggccaca tgctgccaca gctactacac ccctggccac agccaatgga
       790        800        810        820        830        840
agtcccagca atggcaggag caggcgacct aagagtcctc ctccagagaa ggtcccagaa
       850        860        870        880        890        900
gccccatcac aggaggggct gctggcccca ctgagcctgc tgaccctcct gaccttggca
       910        920        930        940
atagccactc tgtatggact cttcctggcc tcacctgggc agtaa 

Last modification date: Oct. 2, 2011