Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Probable DNA-3-methyladenine glycosylase 2


DESCRIPTION:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions (By similarity).

STRUCTURE SIMILARITY:
Belongs to the alkylbase DNA glycosidase AlkA family.


CATALYTIC ACTIVITY:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MSKDSDYKRA EKHLSSIDNK WSSLVKKVGP CTLTPHPEHA PYEGIIRAIT SQKLSDAATN
        70         80         90        100        110        120
SIINKFCTQC SDNDEFPTPK QIMETDVETL HECGFSKLKS QEIHIVAEAA LNKQIPSKSE
       130        140        150        160        170        180
IEKMSEEELM ESLSKIKGVK RWTIEMYSIF TLGRLDIMPA DDSTLKNEAK EFFGLSSKPQ
       190        200        210
TEEVEKLTKP CKPYRTIAAW YLWQIPKLHR KGQ  

Encoded by gid:2540646 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtcaaaag attcggacta caaaagggct gaaaagcatt tatcttcaat tgataacaaa
        70         80         90        100        110        120
tggtcgtctc ttgtcaaaaa agttggacct tgtacactta ctccacatcc agagcacgca
       130        140        150        160        170        180
ccctacgaag gaattattcg agctataaca tcacagaagc tttcagacgc tgccacaaat
       190        200        210        220        230        240
tcaattatca ataaattttg tacacagtgc tcagacaatg acgagtttcc tactcctaag
       250        260        270        280        290        300
caaattatgg aaacagacgt tgaaactttg catgaatgtg gcttttcaaa attaaagtct
       310        320        330        340        350        360
caagagatac acattgttgc agaggctgca ttaaacaagc aaataccttc taaatcggaa
       370        380        390        400        410        420
attgagaaga tgtcggaaga agaactcatg gagtcactaa gtaagataaa aggagtaaaa
       430        440        450        460        470        480
cgatggacca tagaaatgta ctctatcttt acactcggac gactggacat aatgcctgcg
       490        500        510        520        530        540
gatgactcta ctctgaagaa tgaagcaaaa gaattctttg gattatctag caaaccgcaa
       550        560        570        580        590        600
actgaagaag ttgaaaaact aactaaacct tgtaaaccat acagaacaat agctgcttgg
       610        620        630        640
tatttatggc aaattccgaa actccatcgt aaaggccagt aa 

Last modification date: Oct. 2, 2011