Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: Uracil-DNA glycosylase, mitochondrial


DESCRIPTION:
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

MISCELLANEOUS:
Present with 4820 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Belongs to the uracil-DNA glycosylase family.


CATALYTIC ACTIVITY:
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MWCMRRLPTN SVMTVARKRK QTTIEDFFGT KKSTNEAPNK KGKSGATFMT ITNGAAIKTE
        70         80         90        100        110        120
TKAVAKEANT DKYPANSNAK DVYSKNLSSN LRTLLSLELE TIDDSWFPHL MDEFKKPYFV
       130        140        150        160        170        180
KLKQFVTKEQ ADHTVFPPAK DIYSWTRLTP FNKVKVVIIG QDPYHNFNQA HGLAFSVKPP
       190        200        210        220        230        240
TPAPPSLKNI YKELKQEYPD FVEDNKVGDL THWASQGVLL LNTSLTVRAH NANSHSKHGW
       250        260        270        280        290        300
ETFTKRVVQL LIQDREADGK SLVFLLWGNN AIKLVESLLG STSVGSGSKY PNIMVMKSVH
       310        320        330        340        350
PSPLSASRGF FGTNHFKMIN DWLYNTRGEK MIDWSVVPGT SLREVQEANA RLESESKDP

Encoded by UNG1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtggtgca tgagaagatt gccaacaaat tcagttatga cggtggctcg aaagagaaag
        70         80         90        100        110        120
caaactacga tcgaagactt ctttggtaca aagaaaagca ctaatgaggc gcccaataag
       130        140        150        160        170        180
aaaggtaaat cgggcgctac tttcatgacc ataacaaatg gcgcagctat caagacagag
       190        200        210        220        230        240
acaaaggcgg tcgcaaagga ggcaaacacg gacaaatatc ctgctaattc aaatgcaaaa
       250        260        270        280        290        300
gatgtatatt cgaagaactt gagcagcaat ttacgtacac tactgtcgct ggagctagaa
       310        320        330        340        350        360
acgattgatg attcgtggtt tccacattta atggatgaat ttaaaaagcc atattttgta
       370        380        390        400        410        420
aagttgaaac agtttgtcac taaagagcaa gctgatcata cagtatttcc gcctgcaaag
       430        440        450        460        470        480
gatatttact catggaccag gctaacgcct tttaataaag ttaaagtcgt gattatcggt
       490        500        510        520        530        540
caagatccct accacaactt taatcaggcg catggcttgg cttttagcgt caaaccccct
       550        560        570        580        590        600
acaccagcac caccgtcatt aaagaacata tataaggaac tgaagcaaga gtatcctgat
       610        620        630        640        650        660
tttgttgaag ataataaagt gggagattta actcactggg cttcacaagg ggttttattg
       670        680        690        700        710        720
cttaatacct cgttaactgt aagagcacat aatgcaaact cgcattctaa gcatggttgg
       730        740        750        760        770        780
gaaactttta caaaaagggt agttcagttg ttgatccagg acagagaggc cgacggtaag
       790        800        810        820        830        840
agtttagtat tcctcttatg ggggaacaat gctatcaaat tagtagagtc tctgttggga
       850        860        870        880        890        900
tctacttccg ttggaagcgg tagtaagtac cctaatatca tggtgatgaa gtcagtgcat
       910        920        930        940        950        960
ccgtctccat taagtgcaag tagaggattt tttggtacca accatttcaa aatgataaac
       970        980        990       1000       1010       1020
gattggctat acaatacccg cggagagaaa atgatagact ggagtgttgt tcctggaacg
      1030       1040       1050       1060       1070       1080
tcattaagag aagttcagga ggcaaatgct cgcttagagt cagaatcaaa ggacccttga

Last modification date: Oct. 2, 2011