Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: Mitochondrial DNA base excision repair N-glycosylase 1


DESCRIPTION:
Excision repair N-glycosylase involved in the repair of DNA base damage in the mitochondria. NTG1 can use dihydrothymine, urea, and uracil glycol are substrates.

STRUCTURE SIMILARITY:
Belongs to the Nth/MutY family.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MQKISKYSSM AILRKRPLVK TETGPESELL PEKRTKIKQE EVVPQPVDID WVKSLPNKQY
        70         80         90        100        110        120
FEWIVVRNGN VPNRWATPLD PSILVTPAST KVPYKFQETY ARMRVLRSKI LAPVDIIGGS
       130        140        150        160        170        180
SIPVTVASKC GISKEQISPR DYRLQVLLGV MLSSQTKDEV TAMAMLNIMR YCIDELHSEE
       190        200        210        220        230        240
GMTLEAVLQI NETKLDELIH SVGFHTRKAK YILSTCKILQ DQFSSDVPAT INELLGLPGV
       250        260        270        280        290        300
GPKMAYLTLQ KAWGKIEGIC VDVHVDRLTK LWKWVDAQKC KTPDQTRTQL QNWLPKGLWT
       310        320        330        340        350        360
EINGLLVGFG QIITKSRNLG DMLQFLPPDD PRSSLDWDLQ SQLYKEIQQN IMSYPKWVKY
       370        380        390
LEGKRELNVE AEINVKHEEK TVEETMVKLE NDISVKVED  

Encoded by NTG1 gene


OTHER NAME(S):
FUN33
SCR1
ogg2


Nucleic acid sequence

        10         20         30         40         50         60
atgcaaaaga tcagtaaata ctcatctatg gcaattctga ggaaaagacc gctggtaaag
        70         80         90        100        110        120
actgaaactg ggccagaatc agaactccta ccggagaaaa ggaccaaaat caaacaagaa
       130        140        150        160        170        180
gaggttgtcc ctcaacccgt ggatatcgac tgggttaaat cgctgccaaa taagcagtac
       190        200        210        220        230        240
ttcgaatgga ttgtggttag aaacggcaat gtgcccaaca ggtgggccac accattggac
       250        260        270        280        290        300
ccctcgatcc ttgtcactcc ggcctcgacg aaagtccctt acaagtttca agaaacatac
       310        320        330        340        350        360
gctagaatgc gagtactgag atctaagatt ctagcccccg tcgatataat tggtggatca
       370        380        390        400        410        420
tccattcctg taacggttgc ctctaagtgt ggtatctcga aagagcagat atcaccgagg
       430        440        450        460        470        480
gactacagat tacaggtcct tcttggggtg atgctatcat cgcaaacaaa agatgaagtt
       490        500        510        520        530        540
accgcaatgg caatgcttaa cataatgcgg tattgtatag acgaactgca cagcgaagaa
       550        560        570        580        590        600
ggtatgacat tagaggccgt tttacaaatc aatgagacca aattagacga attgattcat
       610        620        630        640        650        660
tcagttgggt tccacacaag gaaggccaag tatattttgt caacctgcaa aatccttcaa
       670        680        690        700        710        720
gatcagtttt cgagtgatgt tccagctacg attaatgagc tattgggcct gcccggtgta
       730        740        750        760        770        780
gggcccaaaa tggcttatct aacattacaa aaggcatggg gcaagattga aggtatctgc
       790        800        810        820        830        840
gttgacgttc acgtggatag attgaccaag ctttggaaat gggtagatgc gcagaaatgc
       850        860        870        880        890        900
aagactccag atcagacaag aactcaatta caaaattggc tgcctaaggg gctttggaca
       910        920        930        940        950        960
gaaataaatg ggttgctggt tggatttgga caaataatca ctaaatcgag gaaccttggt
       970        980        990       1000       1010       1020
gacatgttac aattcttgcc accggatgat cccagaagct ccttagattg ggatttgcag
      1030       1040       1050       1060       1070       1080
tctcaattgt acaaggaaat ccagcaaaat atcatgagtt atccaaagtg ggtgaaatac
      1090       1100       1110       1120       1130       1140
ctggaaggaa aacgtgaact gaacgtggag gcggaaatca atgttaaaca cgaggagaaa
      1150       1160       1170       1180       1190       1200
acagttgaag aaactatggt caaactggaa aatgatattt ctgttaaagt agaggactaa

Last modification date: Oct. 2, 2011