Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA mismatch repair protein PMS1


DESCRIPTION:
Required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLalpha heterodimer that forms a ternary complex with the MutS heterodimers, which initially recognize the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in maintaining the genetic stability of simple sequence repeats and in the repair of heteroduplex sites present in meiotic recombination intermediates.

MISCELLANEOUS:
Present with 521 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutL/hexB family.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MTQIHQINDI DVHRITSGQV ITDLTTAVKE LVDNSIDANA NQIEIIFKDY GLESIECSDN
        70         80         90        100        110        120
GDGIDPSNYE FLALKHYTSK IAKFQDVAKV QTLGFRGEAL SSLCGIAKLS VITTTSPPKA
       130        140        150        160        170        180
DKLEYDMVGH ITSKTTTSRN KGTTVLVSQL FHNLPVRQKE FSKTFKRQFT KCLTVIQGYA
       190        200        210        220        230        240
IINAAIKFSV WNITPKGKKN LILSTMRNSS MRKNISSVFG AGGMRGLEEV DLVLDLNPFK
       250        260        270        280        290        300
NRMLGKYTDD PDFLDLDYKI RVKGYISQNS FGCGRNSKDR QFIYVNKRPV EYSTLLKCCN
       310        320        330        340        350        360
EVYKTFNNVQ FPAVFLNLEL PMSLIDVNVT PDKRVILLHN ERAVIDIFKT TLSDYYNRQE
       370        380        390        400        410        420
LALPKRMCSQ SEQQAQKRLK TEVFDDRSTT HESDNENYHT ARSESNQSNH AHFNSTTGVI
       430        440        450        460        470        480
DKSNGTELTS VMDGNYTNVT DVIGSECEVS VDSSVVLDEG NSSTPTKKLP SIKTDSQNLS
       490        500        510        520        530        540
DLNLNNFSNP EFQNITSPDK ARSLEKVVEE PVYFDIDGEK FQEKAVLSQA DGLVFVDNEC
       550        560        570        580        590        600
HEHTNDCCHQ ERRGSTDTEQ DDEADSIYAE IEPVEINVRT PLKNSRKSIS KDNYRSLSDG
       610        620        630        640        650        660
LTHRKFEDEI LEYNLSTKNF KEISKNGKQM SSIISKRKSE AQENIIKNKD ELEDFEQGEK
       670        680        690        700        710        720
YLTLTVSKND FKKMEVVGQF NLGFIIVTRK VDNKYDLFIV DQHASDEKYN FETLQAVTVF
       730        740        750        760        770        780
KSQKLIIPQP VELSVIDELV VLDNLPVFEK NGFKLKIDEE EEFGSRVKLL SLPTSKQTLF
       790        800        810        820        830        840
DLGDFNELIH LIKEDGGLRR DNIRCSKIRS MFAMRACRSS IMIGKPLNKK TMTRVVHNLS
       850        860        870
ELDKPWNCPH GRPTMRHLME LRDWSSFSKD YEI  

Encoded by PMS1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgacacaaa ttcatcagat aaacgatata gatgttcatc gaattacatc tggacaagtt
        70         80         90        100        110        120
atcaccgact taacaactgc agtgaaagaa ctcgttgata atagtataga tgcgaacgca
       130        140        150        160        170        180
aaccagatcg aaataatctt taaagattat ggtcttgaat ctatcgaatg ttctgataat
       190        200        210        220        230        240
ggtgatggca tagacccttc aaattatgag ttcttagctt taaaacatta cacatcaaaa
       250        260        270        280        290        300
attgcgaaat ttcaagatgt tgctaaagta cagacgttag ggtttagagg ggaggcccta
       310        320        330        340        350        360
tcttctttat gtggcatagc taaactaagt gtgataacaa caacttcacc accaaaagcg
       370        380        390        400        410        420
gataagttgg agtatgatat ggtcggtcac attacttcaa agacaacgac atcaagaaat
       430        440        450        460        470        480
aaagggacga ccgtgttagt ttcgcagtta tttcataact tgcccgttag acagaaagaa
       490        500        510        520        530        540
tttagcaaaa cttttaagcg ccagtttacc aaatgtctca cagttataca aggttatgca
       550        560        570        580        590        600
atcataaatg ctgccattaa attttcagtt tggaatatca caccaaaggg taaaaaaaat
       610        620        630        640        650        660
ctaattctat caacaatgag aaattcaagt atgagaaaga atatatcctc agtattcggt
       670        680        690        700        710        720
gcaggtggta tgcgtgggct tgaagaggtt gatttagtgc ttgatttaaa tcccttcaag
       730        740        750        760        770        780
aatagaatgc ttgggaaata caccgatgat cctgatttct tagacctcga ttataaaatt
       790        800        810        820        830        840
cgagtgaagg gctatatatc acagaattcg tttggttgtg gtagaaatag taaggatagg
       850        860        870        880        890        900
caattcattt atgtgaataa aaggccagtg gaatactcta cgcttttaaa atgctgcaat
       910        920        930        940        950        960
gaggtttaca aaacgttcaa taatgttcaa tttccggctg tatttctcaa tcttgaatta
       970        980        990       1000       1010       1020
cccatgagct taattgatgt aaacgtcact ccagacaaaa gagtgatact gttgcacaac
      1030       1040       1050       1060       1070       1080
gaacgggccg tcattgatat tttcaaaaca actctcagtg attattacaa tagacaagaa
      1090       1100       1110       1120       1130       1140
ttagctcttc ccaaaagaat gtgctcacaa tcagaacaac aagctcagaa aagacttaaa
      1150       1160       1170       1180       1190       1200
acggaagtct ttgatgatag aagcacaaca cacgaatccg ataatgaaaa ctatcatacc
      1210       1220       1230       1240       1250       1260
gccagaagcg aaagtaatca atccaatcat gcacatttta atagtactac tggcgtaata
      1270       1280       1290       1300       1310       1320
gacaaaagta atggtacaga actaacttct gtgatggacg gtaattatac taatgtcact
      1330       1340       1350       1360       1370       1380
gatgtcatcg gttcggagtg tgaagtttcg gttgattcat cagttgtatt ggatgagggc
      1390       1400       1410       1420       1430       1440
aactcaagta caccgactaa gaagctgcca agtatcaaaa cagattctca aaacctaagt
      1450       1460       1470       1480       1490       1500
gatctgaacc tgaataattt ttccaatcct gaatttcaaa atataactag tccagataaa
      1510       1520       1530       1540       1550       1560
gcacgtagct tggaaaaagt tgttgaagaa ccagtttatt ttgatattga tggtgaaaag
      1570       1580       1590       1600       1610       1620
ttccaagaaa aagcggttct atcacaagca gatggtttag tttttgtaga taatgaatgt
      1630       1640       1650       1660       1670       1680
catgagcata caaatgactg ctgtcatcaa gaaagaagag gaagtactga cacagaacaa
      1690       1700       1710       1720       1730       1740
gatgatgaag ctgactctat atacgcagag attgagccag ttgaaatcaa tgtgagaact
      1750       1760       1770       1780       1790       1800
cctctaaaga actcacgtaa atcgatttcc aaagataatt ataggtcatt gagtgatgga
      1810       1820       1830       1840       1850       1860
ttgacgcatc gcaaattcga agatgagata ttggagtaca atttaagcac aaaaaatttt
      1870       1880       1890       1900       1910       1920
aaagaaataa gtaaaaatgg caaacaaatg agtagcatca taagtaaaag aaaatcagaa
      1930       1940       1950       1960       1970       1980
gctcaagaaa acattatcaa aaataaggac gaactagagg atttcgaaca aggagaaaag
      1990       2000       2010       2020       2030       2040
tatctgacgt taacagtttc aaaaaatgat tttaaaaaaa tggaggttgt tggacaattt
      2050       2060       2070       2080       2090       2100
aatttaggat ttatcatagt gaccagaaaa gttgataaca aatatgatct gtttattgtc
      2110       2120       2130       2140       2150       2160
gatcagcatg caagtgatga aaagtataat ttcgaaacac tgcaggccgt gacagttttt
      2170       2180       2190       2200       2210       2220
aaatcgcaga aattgataat acctcagccg gtagaattaa gtgtcattga tgaacttgtg
      2230       2240       2250       2260       2270       2280
gtgctggaca atttaccagt ttttgaaaag aatggattca aattgaaaat tgacgaagaa
      2290       2300       2310       2320       2330       2340
gaagagtttg gctccagagt taagctgtta agcttaccta cttccaaaca aacccttttt
      2350       2360       2370       2380       2390       2400
gatttgggtg attttaatga actgatacat ttgatcaaag aagacggtgg gttacgaaga
      2410       2420       2430       2440       2450       2460
gacaacatca gatgttccaa gattcgttct atgtttgcta tgagagcatg tagaagtagt
      2470       2480       2490       2500       2510       2520
ataatgatag gtaaaccgct gaataagaag actatgacca gagtcgttca taatctcagt
      2530       2540       2550       2560       2570       2580
gaacttgata agccttggaa ttgtccccat ggacgtccaa caatgagaca tttaatggaa
      2590       2600       2610       2620
ttacgtgatt ggagctcatt ttcgaaggat tacgaaatat ga 

Last modification date: Oct. 2, 2011