Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]


STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutS family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MAPSRRQISG RSPLVNQQRQ ITSFFGKSAS SSSSPSPSPS PSLSNKKTPK SNNPNPKSPS
        70         80         90        100        110        120
PSPSPPKKTP KLNPNPSSNL PARSPSPGPD TPSPVQSKFK KPLLVIGQTP SPPQSVVITY
       130        140        150        160        170        180
GDEVVGKQVR VYWPLDKKWY DGSVTFYDKG EGKHVVEYED GEEESLDLGK EKTEWVVGEK
       190        200        210        220        230        240
SGDRFNRLKR GASALRKVVT DSDDDVEMGN VEEDKSDGDD SSDEDWGKNV GKEVCESEED
       250        260        270        280        290        300
DVELVDENEM DEEELVEEKD EETSKVNRVS KTDSRKRKTS EVTKSGGEKK SKTDTGTILK
       310        320        330        340        350        360
GFKASVVEPA KKIGQADRVV KGLEDNVLDG DALARFGARD SEKFRFLGVD RRDAKRRRPT
       370        380        390        400        410        420
DENYDPRTLY LPPDFVKKLT GGQRQWWEFK AKHMDKVVFF KMGKFYELFE MDAHVGAKEL
       430        440        450        460        470        480
DIQYMKGEQP HCGFPEKNFS VNIEKLVRKG YRVLVVEQTE TPDQLEQRRK ETGSKDKVVK
       490        500        510        520        530        540
REVCAVVTKG TLTDGEMLLT NPDASYLMAL TEGGESLTNP TAEHNFGVCL VDVATQKIIL
       550        560        570        580        590        600
GQFKDDQDCS ALSCLLSEMR PVEIIKPAKV LSYATERTIV RQTRNPLVNN LVPLSEFWDS
       610        620        630        640        650        660
EKTIYEVGII YKRINCQPSS AYSSEGKILG DGSSFLPKML SELATEDKNG SLALSALGGA
       670        680        690        700        710        720
IYYLRQAFLD ESLLRFAKFE SLPYCDFSNV NEKQHMVLDA AALENLEIFE NSRNGGYSGT
       730        740        750        760        770        780
LYAQLNQCIT ASGKRLLKTW LARPLYNTEL IKERQDAVAI LRGENLPYSL EFRKSLSRLP
       790        800        810        820        830        840
DMERLIARMF SSIEASGRNG DKVVLYEDTA KKQVQEFIST LRGCETMAEA CSSLRAILKH
       850        860        870        880        890        900
DTSRRLLHLL TPGQSLPNIS SSIKYFKDAF DWVEAHNSGR VIPHEGADEE YDCACKTVEE
       910        920        930        940        950        960
FESSLKKHLK EQRKLLGDAS INYVTVGKDE YLLEVPESLS GSVPHDYELC SSKKGVSRYW
       970        980        990       1000       1010       1020
TPTIKKLLKE LSQAKSEKES ALKSISQRLI GRFCEHQEKW RQLVSATAEL DVLISLAFAS
      1030       1040       1050       1060       1070       1080
DSYEGVRCRP VISGSTSDGV PHLSATGLGH PVLRGDSLGR GSFVPNNVKI GGAEKASFIL
      1090       1100       1110       1120       1130       1140
LTGPNMGGKS TLLRQVCLAV ILAQIGADVP AETFEVSPVD KICVRMGAKD HIMAGQSTFL
      1150       1160       1170       1180       1190       1200
TELSETAVML TSATRNSLVV LDELGRGTAT SDGQAIAESV LEHFIEKVQC RGFFSTHYHR
      1210       1220       1230       1240       1250       1260
LSVDYQTNPK VSLCHMACQI GEGIGGVEEV TFLYRLTPGA CPKSYGVNVA RLAGLPDYVL
      1270       1280       1290       1300       1310       1320
QRAVIKSQEF EALYGKNHRK TDHKLAAMIK QIISSVASDS DYSASKDSLC ELHSMANTFL

RLTN     

Encoded by MSH6 gene


OTHER NAME(S):
ARABIDOPSIS THALIANA MUTS HOMOLOG 6
ATMSH6
MSH6
MSH6-1
MUTS homolog 6
MUTS HOMOLOG 6-1
T10M13.8
T10M13_8


DESCRIPTION:
encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH6 bound the (+T) substrate strongly, (T/G) well, and (+AAG) no better than it did a (T/A) homoduplex.


Nucleic acid sequence

        10         20         30         40         50         60
atggctccgt ctcgccgaca gatcagcgga agatctccgt tggtgaacca gcagcgtcaa
        70         80         90        100        110        120
atcacctcct tctttgggaa atctgcttca tcatcttctt ctccgtctcc atctccttca
       130        140        150        160        170        180
ccatctctct ccaataagaa aacccccaaa tctaacaacc ctaaccctaa atctccgtct
       190        200        210        220        230        240
ccgtcaccat ctccgcctaa gaaaaccccc aaattgaacc ctaaccctag ttctaatctt
       250        260        270        280        290        300
cctgctcgta gtcctagccc tggtcctgat actccttctc ctgtacagtc caagtttaag
       310        320        330        340        350        360
aagccccttc tcgtcatcgg acagacacct tcgcctcctc aatcggtggt aattacttac
       370        380        390        400        410        420
ggtgacgagg tggtggggaa gcaagttagg gtttattggc ctttggataa aaaatggtat
       430        440        450        460        470        480
gatgggagcg tgacgtttta tgataagggt gagggtaagc atgtggttga gtatgaagat
       490        500        510        520        530        540
ggggaagaag agtctttgga tttgggaaag gagaagactg agtgggtggt tggggaaaaa
       550        560        570        580        590        600
tcaggagata ggtttaatcg attgaaacga ggcgcttcgg ctttgagaaa agttgtgacg
       610        620        630        640        650        660
gatagtgatg atgatgtgga gatgggtaat gtggaagaag ataaaagtga cggtgatgat
       670        680        690        700        710        720
tctagcgatg aggattgggg aaagaatgtt gggaaggagg tttgtgagag tgaagaagat
       730        740        750        760        770        780
gatgtggagt tggttgatga gaatgaaatg gatgaagaag agttggtgga agagaaagat
       790        800        810        820        830        840
gaagaaactt ctaaagttaa tagagtatcc aaaactgact ctagaaagcg gaagactagt
       850        860        870        880        890        900
gaagtaacga aatcaggtgg tgagaagaaa agcaagactg atacaggcac tatcttgaaa
       910        920        930        940        950        960
ggttttaagg cttctgttgt ggagcctgcg aagaagattg gacaagctga tagggtggtc
       970        980        990       1000       1010       1020
aagggtttgg aagataacgt gttggatggg gatgctcttg ctagatttgg tgctcgtgat
      1030       1040       1050       1060       1070       1080
tctgagaaat tccgcttttt gggagtagac cgaagggatg ctaaaaggag acgccctact
      1090       1100       1110       1120       1130       1140
gatgagaatt atgatccgag gacactctac ctccctcctg attttgtgaa aaaattaact
      1150       1160       1170       1180       1190       1200
ggaggccaga gacaatggtg ggagtttaaa gcaaagcata tggacaaagt tgtattcttc
      1210       1220       1230       1240       1250       1260
aagatgggta aattctatga gctttttgag atggatgcac atgtcggagc taaggaactg
      1270       1280       1290       1300       1310       1320
gatatacaat acatgaaggg agagcaacct cattgtggat ttccggagaa gaatttttct
      1330       1340       1350       1360       1370       1380
gtaaacattg agaaattagt tagaaagggc tatcgggttt tagttgtcga acaaacagaa
      1390       1400       1410       1420       1430       1440
acacctgatc agctggagca acgccgaaaa gagacaggtt ccaaggataa agttgtgaag
      1450       1460       1470       1480       1490       1500
cgcgaagtat gtgcagttgt tacaaaaggc acgctgacag atggggagat gctattaact
      1510       1520       1530       1540       1550       1560
aatccggatg catcttatct aatggccttg actgaaggag gagaaagttt aactaatcct
      1570       1580       1590       1600       1610       1620
acagcagagc acaattttgg tgtatgtttg gttgatgttg cgacacagaa gataatactg
      1630       1640       1650       1660       1670       1680
ggccagttta aggatgatca agattgcagt gcattatctt gcctgctatc tgagatgagg
      1690       1700       1710       1720       1730       1740
ccggtggaaa ttattaaacc agctaaggtg ttgagttatg caacagagag aacaatagtt
      1750       1760       1770       1780       1790       1800
agacaaacca gaaatccctt agtaaataat ctcgttccac tttctgaatt ttgggattcg
      1810       1820       1830       1840       1850       1860
gagaagacca tatatgaagt tggaattatc tacaagcgaa tcaattgtca accgtcttct
      1870       1880       1890       1900       1910       1920
gcttattcta gtgagggaaa gattctaggt gatggttcaa gctttcttcc aaaaatgttg
      1930       1940       1950       1960       1970       1980
tctgaattag caactgaaga taagaatggt agcctggcac tctctgctct tggtggtgcc
      1990       2000       2010       2020       2030       2040
atttactacc tgcgacaagc attcttggat gagagtctgc ttagatttgc aaagtttgaa
      2050       2060       2070       2080       2090       2100
tccctgcctt actgtgattt cagcaacgtt aatgagaagc agcacatggt tcttgatgct
      2110       2120       2130       2140       2150       2160
gctgctcttg aaaaccttga gatatttgaa aacagtagaa atggaggcta ttcaggaacg
      2170       2180       2190       2200       2210       2220
ctgtatgctc aactgaatca atgtatcact gcatctggga aacggttact gaaaacatgg
      2230       2240       2250       2260       2270       2280
ctggcaagac ctttatataa tacggaactg atcaaggaac gacaagatgc tgtagcaatt
      2290       2300       2310       2320       2330       2340
ctgcggggtg aaaatcttcc gtactcactg gaattccgga agtcgttgtc cagacttcca
      2350       2360       2370       2380       2390       2400
gacatggaac ggttgattgc acgtatgttt tctagcattg aagctagtgg aagaaatggc
      2410       2420       2430       2440       2450       2460
gataaagtgg tgctatatga agatacagct aagaagcagg tacaggaatt catatcaact
      2470       2480       2490       2500       2510       2520
ctacgtggtt gtgaaacaat ggcagaagca tgctcttctc tccgtgctat cttgaagcat
      2530       2540       2550       2560       2570       2580
gatacatcca ggcggctgct tcatttacta actcctggtc aaagtcttcc aaatatatca
      2590       2600       2610       2620       2630       2640
tcctccataa agtatttcaa ggatgctttt gactgggtag aagctcacaa ttctggacgt
      2650       2660       2670       2680       2690       2700
gtaatacccc atgaaggagc agatgaagag tatgattgtg cctgcaaaac agtagaagaa
      2710       2720       2730       2740       2750       2760
tttgagtcca gtttgaaaaa acatctgaaa gagcaacgga aattactcgg agatgcatca
      2770       2780       2790       2800       2810       2820
ataaactatg ttacagttgg aaaagatgaa tacctcttgg aagttcctga aagtttaagt
      2830       2840       2850       2860       2870       2880
gggagtgttc ctcatgatta tgaattatgc tcatcgaaaa agggtgtctc tcgatattgg
      2890       2900       2910       2920       2930       2940
actcctacca taaagaaatt attaaaagag ctatcacaag caaaatctga aaaagagtcg
      2950       2960       2970       2980       2990       3000
gccctgaaga gcatttcaca gagattgatt ggacgtttct gcgagcatca agaaaaatgg
      3010       3020       3030       3040       3050       3060
agacaattgg tttctgcaac agctgagctg gacgtgttga tcagcctcgc ttttgcaagt
      3070       3080       3090       3100       3110       3120
gattcttatg aaggagtaag atgccgccca gtaatatctg gttctacatc tgatggtgtt
      3130       3140       3150       3160       3170       3180
ccacacttgt ctgccactgg tctagggcat ccagttctaa ggggtgattc gttaggcaga
      3190       3200       3210       3220       3230       3240
ggctcttttg taccaaataa tgtaaagata ggtggtgctg agaaagccag tttcatcctc
      3250       3260       3270       3280       3290       3300
ctcacaggcc ctaatatggg tggaaaatca acccttcttc gccaagtttg cttggctgta
      3310       3320       3330       3340       3350       3360
atcttggctc agattggagc agatgtccca gcagaaacct ttgaggtttc gcctgttgac
      3370       3380       3390       3400       3410       3420
aaaatttgtg tccggatggg tgcaaaagat catatcatgg caggacaaag cacgttttta
      3430       3440       3450       3460       3470       3480
acagaacttt cagaaactgc ggtaatgttg acatcagcca cccgaaactc gctggtggtg
      3490       3500       3510       3520       3530       3540
ctagatgagc ttggacgagg aacagccaca tcagatgggc aagccattgc ggaatccgta
      3550       3560       3570       3580       3590       3600
cttgagcact tcatagaaaa ggtgcagtgt agaggattct tctctactca ttatcatcgt
      3610       3620       3630       3640       3650       3660
ctctctgtgg attatcaaac caatccaaag gtctcacttt gccatatggc atgtcaaata
      3670       3680       3690       3700       3710       3720
ggagaaggaa tcggtggagt agaagaagtt acatttctct atagattgac tcctggtgca
      3730       3740       3750       3760       3770       3780
tgtcctaaaa gttatggagt taacgttgct cggttagctg gtcttccaga ttacgtactc
      3790       3800       3810       3820       3830       3840
cagagagccg tgataaaatc ccaagaattc gaggctttgt acggtaaaaa ccatagaaaa
      3850       3860       3870       3880       3890       3900
accgatcata aattagcagc aatgataaag cagatcatca gcagtgttgc atcagattct
      3910       3920       3930       3940       3950       3960
gattactcag cttcaaagga ctcattgtgt gagctacact ccatggccaa tacatttctc
      3970
cggttaacca actaa    

Last modification date: Oct. 2, 2011