Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA mismatch repair protein Msh2


DESCRIPTION:
Involved in postreplication mismatch repair. Binds specifically to DNA containing mismatched nucleotides thus providing a target for the excision repair processes characteristic of postreplication mismatch repair (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA mismatch repair mutS family.


RELATED PATHWAY(S):
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MEGNFEEQNK LPELKLDAKQ AQGFLSFYKT LPNDTRAVRF FDRKDYYTAH GENSVFIAKT
        70         80         90        100        110        120
YYHTTTALRQ LGSGSNALSS VSISRNMFET IARDLLLERN DHTVELYEGS GSNWRLVKTG
       130        140        150        160        170        180
SPGNIGSFED VLFANNEMQD TPVVVSIFPS FHDGRCVIGM AYVDLTRRVL GLAEFLDDSR
       190        200        210        220        230        240
FTNLESSLIA LGAKECIFPA ESGKSNECKS LYDSLERCAV MITERKKHEF KGRDLDSDLK
       250        260        270        280        290        300
RLVKGNIEPV RDLVSGFDLA TPALGALLSF SELLSNEDNY GNFTIRRYDI GGFMRLDSAA
       310        320        330        340        350        360
MRALNVMESK TDANKNFSLF GLMNRTCTAG MGKRLLHMWL KQPLVDLNEI KTRLDIVQCF
       370        380        390        400        410        420
VEEAGLRQDL RQHLKRISDV ERLLRSLERR RGGLQHIIKL YQSTIRLPFI KTAMQQYTGE
       430        440        450        460        470        480
FASLISERYL KKLEALSDQD HLGKFIDLVE CSVDLDQLEN GEYMISSSYD TKLASLKDQK
       490        500        510        520        530        540
ELLEQQIHEL HKKTAIELDL QVDKALKLDK AAQFGHVFRI TKKEEPKIRK KLTTQFIVLE
       550        560        570        580        590        600
TRKDGVKFTN TKLKKLGDQY QSVVDDYRSC QKELVDRVVE TVTSFSEVFE DLAGLLSEMD
       610        620        630        640        650        660
VLLSFADLAA SCPTPYCRPE ITSSDAGDIV LEGSRHPCVE AQDWVNFIPN DCRLMRGKSW
       670        680        690        700        710        720
FQIVTGPNMG GKSTFIRQVG VIVLMAQVGS FVPCDKASIS IRDCIFARVG AGDCQLRGVS
       730        740        750        760        770        780
TFMQEMLETA SILKGASDKS LIIIDELGRG TSTYDGFGLA WAICEHLVQV KRAPTLFATH
       790        800        810        820        830        840
FHELTALAQA NSEVSGNTVG VANFHVSAHI DTESRKLTML YKVEPGACDQ SFGIHVAEFA
       850        860        870        880        890        900
NFPESVVALA REKAAELEDF SPSSMIINNE ESGKRKSRED DPDEVSRGAE RAHKFLKEFA
       910        920        930
AIPLDKMELK DSLQRVREMK DELEKDAADC HWLRQFL  

Encoded by MSH2 gene


OTHER NAME(S):
ATMSH2
MSH2
MUTS homolog 2


DESCRIPTION:
Encodes a DNA mismatch repair homolog of human MutS gene, MSH6. MSH2 is involved in maintaining genome stability and repressing recombination of mismatched heteroduplexes.There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2 has different binding specificity to different mismatches in combination with MSH3, MSH6, or MSH7.


Nucleic acid sequence

        10         20         30         40         50         60
atggagggta atttcgagga acagaacaag cttccggagc tgaaattgga tgcaaagcaa
        70         80         90        100        110        120
gctcaagggt ttctctcgtt ctacaaaacc ctaccaaatg atacgagagc tgttagattc
       130        140        150        160        170        180
tttgatcgca aggattatta tacagctcat ggtgaaaatt cagttttcat tgcaaagact
       190        200        210        220        230        240
tattatcata caaccactgc tctacgtcag ctcgggagtg gttcaaatgc tctttcaagc
       250        260        270        280        290        300
gtaagcatta gtaggaacat gttcgaaacg attgctaggg atcttctcct ggagcgtaat
       310        320        330        340        350        360
gatcatactg tagaacttta tgagggaagc ggatcgaatt ggagacttgt gaaaacaggt
       370        380        390        400        410        420
tctcctggaa acattggaag ctttgaagat gttttgtttg caaacaatga aatgcaggac
       430        440        450        460        470        480
acaccagttg ttgtctccat atttccaagt tttcacgatg gcagatgcgt tattgggatg
       490        500        510        520        530        540
gcctatgttg atctgactag gcgagttctt ggactagctg agtttcttga tgatagccgc
       550        560        570        580        590        600
ttcaccaatc tggagtcttc gttgattgct ctaggcgcaa aagaatgcat ttttccagct
       610        620        630        640        650        660
gaatccggca aatccaatga atgcaaaagc ctgtatgatt ccctggagag gtgtgccgtg
       670        680        690        700        710        720
atgataacag agaggaagaa acacgagttc aaaggaagag atttagattc agatcttaag
       730        740        750        760        770        780
agattggtga aggggaatat tgagcctgtt agagatttgg tatccgggtt tgaccttgcg
       790        800        810        820        830        840
actcctgctc taggtgcatt actctcgttt tctgaacttc tctcaaatga ggataactat
       850        860        870        880        890        900
gggaacttca caatccgcag atatgatatt ggcggattca tgagacttga ctctgcagct
       910        920        930        940        950        960
atgagggctt tgaatgtgat ggagagcaaa actgatgcta ataagaattt cagtttgttt
       970        980        990       1000       1010       1020
ggtctcatga acagaacatg taccgcaggg atgggtaaga gactgcttca tatgtggctg
      1030       1040       1050       1060       1070       1080
aagcaacccc tcgtggattt gaatgagatt aagacgagat tagatatagt tcagtgcttt
      1090       1100       1110       1120       1130       1140
gttgaagaag ctgggttaag gcaggatctt agacagcatc tgaagcgaat ctcagatgtt
      1150       1160       1170       1180       1190       1200
gagaggcttt tgcgcagtct cgagagaaga agaggtgggt tacagcacat tattaaactc
      1210       1220       1230       1240       1250       1260
tatcagtcaa ctataaggct tcccttcatc aaaacagcta tgcaacagta caccggagaa
      1270       1280       1290       1300       1310       1320
ttcgcatcac tcatcagcga gagatacctg aaaaagcttg aggctttatc agatcaagat
      1330       1340       1350       1360       1370       1380
caccttggaa agttcatcga tttggttgag tgctctgtag atcttgacca gctagaaaat
      1390       1400       1410       1420       1430       1440
ggagaataca tgatatcttc aagctacgac accaaattgg catctctgaa agatcagaaa
      1450       1460       1470       1480       1490       1500
gaattgctgg agcagcagat tcacgaattg cacaaaaaga cagcgataga acttgatctt
      1510       1520       1530       1540       1550       1560
caggtcgaca aggctcttaa acttgacaaa gcagcgcaat ttgggcatgt cttcaggatc
      1570       1580       1590       1600       1610       1620
acgaagaagg aagagccaaa gatcaggaag aagctgacga cacagtttat agtgctggag
      1630       1640       1650       1660       1670       1680
actcgcaaag acggagtgaa gttcacaaac acaaagctaa aaaaactggg ggaccagtac
      1690       1700       1710       1720       1730       1740
caaagtgttg tggatgatta taggagctgt caaaaggagc tcgttgatcg tgtagttgag
      1750       1760       1770       1780       1790       1800
actgttacca gcttctctga ggtatttgag gacttagctg ggttactttc tgaaatggat
      1810       1820       1830       1840       1850       1860
gttttgttaa gctttgctga tttggctgcc agttgcccta ctccatactg taggccagaa
      1870       1880       1890       1900       1910       1920
atcacctctt cggatgctgg agatattgta ctagaaggaa gcagacatcc atgtgtagaa
      1930       1940       1950       1960       1970       1980
gctcaagatt gggtgaattt cataccaaat gattgcagac tcatgagagg gaagagttgg
      1990       2000       2010       2020       2030       2040
tttcaaatag taacagggcc taacatggga gggaagtcca ctttcatccg ccaggttggt
      2050       2060       2070       2080       2090       2100
gtgattgtgc tgatggctca agttggttcc tttgttcctt gtgataaagc atcaatttcc
      2110       2120       2130       2140       2150       2160
ataagagact gcatctttgc ccgtgtagga gcaggcgatt gccaactgcg tggagtgtca
      2170       2180       2190       2200       2210       2220
acttttatgc aagaaatgct tgaaaccgca tcgatattga aaggcgctag tgataagtca
      2230       2240       2250       2260       2270       2280
ctgataatta tcgatgaact tggtcgtgga acatcaactt atgatggttt tggtttagct
      2290       2300       2310       2320       2330       2340
tgggctatat gtgagcatct ggttcaagtg aaaagagcac caactctgtt tgctactcac
      2350       2360       2370       2380       2390       2400
ttccatgaac ttactgcctt ggctcaagca aactctgagg tctctggtaa cactgttggt
      2410       2420       2430       2440       2450       2460
gtggcaaact tccatgtcag cgctcacatt gacactgaaa gccgcaaact caccatgctt
      2470       2480       2490       2500       2510       2520
tacaaggttg aaccaggggc ctgtgaccag agctttggga ttcatgtggc ggaatttgcc
      2530       2540       2550       2560       2570       2580
aacttccctg aaagcgtcgt ggccctcgca agagagaaag ctgcagagct ggaagatttc
      2590       2600       2610       2620       2630       2640
tctccctcct ccatgataat caacaatgag gagagtggga agagaaagag cagagaagat
      2650       2660       2670       2680       2690       2700
gatccagatg aagtatcaag aggggcagag cgagctcaca agtttctgaa agagtttgca
      2710       2720       2730       2740       2750       2760
gcgataccac ttgataaaat ggagcttaaa gattcacttc aacgggttcg tgagatgaaa
      2770       2780       2790       2800       2810
gatgagctag agaaagatgc tgcagactgc cactggctca ggcagtttct gtga

Last modification date: Oct. 2, 2011