Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: A/G-specific adenine glycosylase


DESCRIPTION:
Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).

STRUCTURE SIMILARITY:
Belongs to the Nth/MutY family.


PROTEIN TYPE(S):
DNA N-glycosylase


RELATED PATHWAY(S):
base excision repair (BER)


RELATED DAMAGE:
2-oxoA
A from A:G
A from A:C
2-oxoA from 2-oxoA:G
8-oxoG from 8-oxoG:A
2-hydroxy-A (2-OH-A)


Amino acids sequence

        10         20         30         40         50         60
MQASQFSAQV LDWYDKYGRK TLPWQIDKTP YKVWLSEVML QQTQVATVIP YFERFMARFP
        70         80         90        100        110        120
TVTDLANAPL DEVLHLWTGL GYYARARNLH KAAQQVATLH GGKFPETFEE VAALPGVGRS
       130        140        150        160        170        180
TAGAILSLSL GKHFPILDGN VKRVLARCYA VSGWPGKKEV ENKLWSLSEQ VTPAVGVERF
       190        200        210        220        230        240
NQAMMDLGAM ICTRSKPKCS LCPLQNGCIA AANNSWALYP GKKPKQTLPE RTGYFLLLQH
       250        260        270        280        290        300
EDEVLLAQRP PSGLWGGLYC FPQFADEESL RQWLAQRQIA ADNLTQLTAF RHTFSHFHLD
       310        320        330        340        350
IVPMWLPVSS FTGCMDEGNA LWYNLAQPPS VGLAAPVERL LQQLRTGAPV 

Encoded by mutY gene


OTHER NAME(S):
ECK2956
JW2928
micA
mutB


DESCRIPTION:
MutY serves as an adenine glycosylase mismatch repair enzyme in Escherichia coli which works to correct G-A mispairs to G-C base pairs. [More information is available at EcoCyc: EG10627].


Nucleic acid sequence

        10         20         30         40         50         60
atgcaagcgt cgcaattttc agcccaggtt ctggactggt acgataaata cgggcgaaaa
        70         80         90        100        110        120
actctgccct ggcaaattga caagacgccc tacaaagtat ggctctcaga agtgatgttg
       130        140        150        160        170        180
caacaaactc aggttgcgac cgttatcccc tattttgaac gctttatggc gcgcttcccg
       190        200        210        220        230        240
acggtgaccg atctcgccaa tgcgccgctc gacgaagttc tccacttgtg gaccgggctt
       250        260        270        280        290        300
ggctattacg cccgcgcgcg caatctgcat aaagcggcac aacaagtggc gaccttacac
       310        320        330        340        350        360
ggcggtaaat tcccggaaac ctttgaggaa gttgcagcac tgccgggcgt cgggcgttcc
       370        380        390        400        410        420
accgcaggcg cgattctctc gctttctctg ggtaagcact ttccgattct cgacggtaac
       430        440        450        460        470        480
gtcaaacgcg tgctggcgcg ctgctatgct gtaagcggct ggcctgggaa aaaagaggtc
       490        500        510        520        530        540
gagaataaat tatggagttt gagcgagcag gtgacgcccg cggttggcgt ggaacggttt
       550        560        570        580        590        600
aatcaggcga tgatggattt gggtgcgatg atttgtacgc gctcgaaacc gaaatgttcg
       610        620        630        640        650        660
ctctgtccgc tacaaaacgg atgtattgcc gccgccaaca atagctgggc gctttatccg
       670        680        690        700        710        720
ggcaaaaaac cgaaacagac gctgccggag cgcaccggct actttttgct attacagcac
       730        740        750        760        770        780
gaagatgaag tattgctggc gcagcgtccg ccgagcggat tgtggggcgg tttatactgt
       790        800        810        820        830        840
ttcccgcagt ttgccgacga agaaagtttg cggcagtggc tggcgcaacg gcagattgct
       850        860        870        880        890        900
gccgataacc tgacgcaact gaccgcgttt cggcatacct tcagccattt ccacttagat
       910        920        930        940        950        960
attgtgccta tgtggcttcc cgtgtcgtca ttcaccggct gcatggatga aggcaatgcg
       970        980        990       1000       1010       1020
ctctggtata acttagcgca accgccgtca gttggcctag cggctcccgt ggagcgtttg
      1030       1040       1050
ttacagcagt tacgcactgg cgcgccggtt tag  

Last modification date: Oct. 2, 2011