Homo sapiens L. (human) [HSA]

FULL NAME: Replication protein A 14 kDa subunit


DESCRIPTION:
Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

SUBUNIT STRUCTURE:
Heterotrimer of 70, 32 and 14 kDa chains (canonical replication protein A complex). Component of the alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Interacts with RPA4.


RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MVDMMDLPRS RINAGMLAQF IDKPVCFVGR LEKIHPTGKM FILSDGEGKN GTIELMEPLD
        70         80         90        100        110        120
EEISGIVEVV GRVTAKATIL CTSYVQFKED SHPFDLGLYN EAVKIIHDFP QFYPLGIVQH

D     

Encoded by RPA3 gene

FULL NAME: replication protein A3, 14kDa


OTHER NAME(S):
REPA3


Nucleic acid sequence

        10         20         30         40         50         60
atggtggaca tgatggactt gcccaggtcg cgcatcaacg ccggcatgct agctcaattc
        70         80         90        100        110        120
atcgacaagc ctgtctgctt cgtagggagg ctggaaaaga ttcatcccac cggaaaaatg
       130        140        150        160        170        180
tttattcttt cagatggaga aggaaaaaat ggaaccatcg agttgatgga accccttgat
       190        200        210        220        230        240
gaagaaatct ctggaattgt ggaagtggtt ggaagagtaa ccgccaaggc caccatcttg
       250        260        270        280        290        300
tgtacatctt atgtccagtt taaagaagat agccatcctt ttgatcttgg actttacaat
       310        320        330        340        350        360
gaagctgtga aaattatcca tgacttccct cagttttatc ctttagggat tgtgcaacat

gattga     

Last modification date: Oct. 2, 2011