Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA excision repair protein ERCC-1


DESCRIPTION:
Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5' to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. In vitro, is involved in chromosomal recombination between tandem repeats in both direct and inverted orientations. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase.

STRUCTURE SIMILARITY:
Belongs to the ERCC1/RAD10/SWI10 family.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MANEDDDGEK SRSLHQQIAR KPKTQIVIGV PSYQEVLESS QTKSTPPSLF KPSQSFSQAF
        70         80         90        100        110        120
AFVKSSDVYS PPPPSSAAAS SSQPSGASQV PHSSSQTHQT DGASSSSTPV ATGSVPSNTT
       130        140        150        160        170        180
QNRNAILVSH RQKGNPLLKH IRNVKWVFSD IIPDYVLGQN SCALYLSLRY HLLHPDYLYF
       190        200        210        220        230        240
RIRELQKNFK LSVVLCHVDV EDTVKPLLEV TKTALLHDCT LLCAWSMTEC ARYLETIKVY
       250        260        270        280        290        300
ENKPADLIQG QMDTDYLSRL NHSLTSIRHV NKSDVVTLGS TFGSLAHIID ASMEDLARCP
       310        320        330        340        350        360
GIGERKVKRL YDTFHEPFKR ATSSYPSVVE PPIPEAPVEK DVNSEEPVEE DEDFVEDSRK
       370        380        390        400        410
RKKKEPEPEK TVKTALSAVF ARYSDRLSKK KEKQKEKDTT TASDAETHQN 

Encoded by ERCC1 gene


OTHER NAME(S):
T12H1.18
T12H1_18
UV REPAIR DEFICIENT 7
UVR7


DESCRIPTION:
encodes a homolog of human ERCC1 protein (yeast RAD10), which is a DNA repair endonuclease. Mutants are sensitive to UV-B and gamma radiation (G2 cell cycle phase arrest) and are defective in dark-repair of pyrimidine pyrimidone dimers. This protein incises the 5' end of damaged DNA, similar to ERCC1/RAD10.


Nucleic acid sequence

        10         20         30         40         50         60
atggcgaacg aagacgacga cggtgagaaa tccagaagtc tgcaccaaca gattgctaga
        70         80         90        100        110        120
aaacccaaaa cccagatcgt gattggtgtg ccatcgtacc aggaagtttt ggaaagctca
       130        140        150        160        170        180
cagacgaagt ccacgcctcc atctctcttc aagccttccc agagtttctc tcaggctttc
       190        200        210        220        230        240
gctttcgtca agtcgtccga cgtctactct cctcctcctc cttcctccgc agccgcctct
       250        260        270        280        290        300
tcttctcagc cgtcgggcgc ttctcaggtg ccccacagtt caagccaaac gcatcaaact
       310        320        330        340        350        360
gatggagcct catcttcttc tactcctgta gccactggct ctgtaccatc aaacacaact
       370        380        390        400        410        420
caaaatcgta acgctattct cgttagccat cgacagaaag gaaacccgct tcttaaacat
       430        440        450        460        470        480
atcaggaatg tgaaatgggt tttctcagat atcattccag attacgtgct tggtcaaaac
       490        500        510        520        530        540
tcttgcgctt tgtatttaag cttgcggtat catctcctac atccggatta cctctatttc
       550        560        570        580        590        600
cgcattaggg aactacaaaa gaatttcaag ctaagtgttg ttctttgcca tgtcgacgtg
       610        620        630        640        650        660
gaagatacgg tgaaaccgtt gcttgaagtc acaaaaaccg ctctacttca tgattgcact
       670        680        690        700        710        720
ctattgtgtg cctggagcat gacagaatgt gcccgttatt tggaaacgat aaaagtctat
       730        740        750        760        770        780
gaaaacaaac ctgcagatct catccaaggc caaatggata cagattacct ttcacggcta
       790        800        810        820        830        840
aaccattctc ttacaagcat tcgacatgta aacaagagcg atgtagttac acttggttct
       850        860        870        880        890        900
acattcgggt ctcttgctca tataatcgat gcatccatgg aagatttagc acgttgtccc
       910        920        930        940        950        960
gggattggcg aacgtaaggt gaagcggttg tatgatacat tccacgagcc tttcaagcgt
       970        980        990       1000       1010       1020
gcaacttcga gctacccgtc tgttgtagaa ccaccaatcc cggaagctcc agttgagaag
      1030       1040       1050       1060       1070       1080
gatgtgaact cagaggaacc tgttgaagaa gacgaggatt ttgtggagga ctcgagaaaa
      1090       1100       1110       1120       1130       1140
cgcaagaaga aggagcccga gcccgagaaa actgtgaaga ccgcactctc tgctgttttt
      1150       1160       1170       1180       1190       1200
gctcgttact ctgatagact tagcaagaaa aaggagaaac agaaggagaa agatacaaca
      1210       1220       1230
acggcgtcag atgctgaaac ccaccaaaat taa  

Last modification date: Oct. 2, 2011