Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA repair protein UVH3


DESCRIPTION:
Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3'-incision step in NER. Seems to play a role in senescence program.

STRUCTURE SIMILARITY:
Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MGVQGLWELL APVGRRVSVE TLANKRLAID ASIWMVQFIK AMRDEKGDMV QNAHLIGFFR
        70         80         90        100        110        120
RICKLLFLRT KPIFVFDGAT PALKRRTVIA RRRQRENAQT KIRKTAEKLL LNRLKDIRLK
       130        140        150        160        170        180
EQAKDIKNQR LKQDDSDRVK KRVSSDSVED NLRVPVEEDD VGASFFQEEK LDEVSQASLV
       190        200        210        220        230        240
GETGVDDVVK ESVKDDPKGK GVLLDGDDLD NLVQDSSVQG KDYQEKLDEM LAASLAAEEE
       250        260        270        280        290        300
RNFTSKASTS AAAIPSEEDE EEDSDGDEEI LLPVMDGNID PAVLASLPPS MQLDLLAQMR
       310        320        330        340        350        360
EKLMAENRQK YQKVKKAPEK FSELQIEAYL KTVAFRREIN EVQRSAGGRA VGGVQTSRIA
       370        380        390        400        410        420
SEANREFIFS SSFAGDKEVL ASAREGRNDE NQKKTSQQSL PVSVKNASPL KKSDATIELD
       430        440        450        460        470        480
RDEPKNPDEN IEVYIDERGR FRIRNRHMGI QMTRDIQRNL HLMKEKERTA SGSMAKNDET
       490        500        510        520        530        540
FSAWENFPTE DQFLEKSPVE KDVVDLEIQN DDSMLHPPSS IEISFDHDGG GKDLNDEDDM
       550        560        570        580        590        600
FLQLAAGGPV TISSTENDPK EDTSPWASDS DWEEVPVEQN TSVSKLEANL SNQHIPKDIS
       610        620        630        640        650        660
IAEGVAWEEY SCKNANNSVE NDTVTKITKG YLEEEADLQE AIKKSLLELH DKESGDVLEE
       670        680        690        700        710        720
NQSVRVNLVV DKPSEDSLCS RETVGEAEEE RFLDEITILK TSGAISEQSN TSVAGNADGQ
       730        740        750        760        770        780
KGITKQFGTH PSSGSNNVSH AVSNKLSKVK SVISPEKALN VASQNRMLST MAKQHNEEGS
       790        800        810        820        830        840
ESFGGESVKV SAMPIADEEI TGFLDEKDNA DGESSIMMDD KRDYSRRKIQ SLVTESRDPS
       850        860        870        880        890        900
RNVVRSRIGI LHDTDSQNER REENNSNEHT FNIDSSTDFE EKGVPVEFSE ANIEEEIRVL
       910        920        930        940        950        960
DQEFVSLGDE QRKLERNAES VSSEMFAECQ ELLQIFGIPY IIAPMEAEAQ CAFMEQSNLV
       970        980        990       1000       1010       1020
DGIVTDDSDV FLFGARSVYK NIFDDRKYVE TYFMKDIEKE LGLSRDKIIR MAMLLGSDYT
      1030       1040       1050       1060       1070       1080
EGISGIGIVN AIEVVTAFPE EDGLQKFREW VESPDPTILG KTDAKTGSKV KKRGSASVDN
      1090       1100       1110       1120       1130       1140
KGIISGASTD DTEEIKQIFM DQHRKVSKNW HIPLTFPSEA VISAYLNPQV DLSTEKFSWG
      1150       1160       1170       1180       1190       1200
KPDLSVLRKL CWEKFNWNGK KTDELLLPVL KEYEKRETQL RIEAFYSFNE RFAKIRSKRI
      1210       1220       1230       1240       1250       1260
NKAVKGIGGG LSSDVADHTL QEGPRKRNKK KVAPHETEDN NTSDKDSPIA NEKVKNKRKR
      1270       1280       1290       1300       1310       1320
LEKPSSSRGR GRAQKRGRGR GRVQKDLLEL SDGSSDDDDD DDKVVELEAK PANLQKSTRS
      1330       1340       1350       1360       1370       1380
RNPVMYSAKE DDELDESRSN EGSPSENFEE VDEGRIGNDD SVDASINDCP SEDYIQTGGG
      1390       1400       1410       1420       1430       1440
FCADEADEIG DAHLEDKATD DYRVIGGGFC VDEDETAEEN TMDDDAEILK MESEEQRKKG
      1450       1460       1470
KRRNEEDASL DENVDIHFGN SSAGGLSAMP FLKRKKRKN  

Encoded by UVH3 gene


OTHER NAME(S):
ULTRAVIOLET HYPERSENSITIVE 3
UV REPAIR DEFECTIVE 1
UVH3
UVR1


DESCRIPTION:
Required for repair of pyrimidine-pyrimidinone (6-4) dimers.


Nucleic acid sequence

        10         20         30         40         50         60
atgggagtac aaggtctttg ggagcttctt gctcctgttg gtcgccgtgt ctccgtagaa
        70         80         90        100        110        120
accctagcca acaaacgatt agccatcgat gcgagtatat ggatggtaca atttatcaaa
       130        140        150        160        170        180
gcgatgcgtg acgagaaggg agatatggtt cagaatgcac acttgatcgg gttttttcga
       190        200        210        220        230        240
aggatttgta agcttttgtt tctaaggact aaaccgatct tcgtctttga tggagctact
       250        260        270        280        290        300
ccggcattga aacgtcgtac tgttattgct cgccgtcgtc aacgtgagaa cgctcagact
       310        320        330        340        350        360
aaaatccgga agactgctga gaaattgctg cttaataggc ttaaggatat taggcttaag
       370        380        390        400        410        420
gaacaagcta aagatattaa gaatcagaga ttgaagcagg atgatagtga tagagtgaag
       430        440        450        460        470        480
aaacgtgtgt cttctgattc tgtggaagat aatttgcgag ttcctgtgga ggaagatgat
       490        500        510        520        530        540
gtaggggcga gtttttttca ggaggagaag ctagatgaag tatctcaagc atctttggtg
       550        560        570        580        590        600
ggagagactg gtgttgatga tgttgtcaaa gagtccgtga aggatgatcc caagggaaag
       610        620        630        640        650        660
ggagttttgt tggatgggga tgacctagat aatcttgtac aggattcctc agtacagggg
       670        680        690        700        710        720
aaggattatc aggaaaagtt ggatgagatg ttggcggcat cccttgcagc tgaagaagaa
       730        740        750        760        770        780
cgaaacttta ctagcaaagc atcgacttca gctgcagcaa tcccgtcaga ggaggatgag
       790        800        810        820        830        840
gaagaagaca gcgacggaga tgaggaaatt ttattgccag taatggatgg gaatatcgac
       850        860        870        880        890        900
ccagctgttc tggcttctct ccctccatcc atgcaacttg atctccttgc tcagatgaga
       910        920        930        940        950        960
gaaaaattga tggcagaaaa ccggcaaaag taccaaaagg tcaagaaggc ccctgaaaag
       970        980        990       1000       1010       1020
ttttctgaat tgcaaataga agcatatctt aaaactgtag ccttccgtcg cgaaataaat
      1030       1040       1050       1060       1070       1080
gaagttcaga gatctgctgg tggaagggct gttggtggag ttcaaacttc taggatagct
      1090       1100       1110       1120       1130       1140
tcggaagcaa acagagagtt tatattctcg tcttcttttg ctggtgataa agaagtactg
      1150       1160       1170       1180       1190       1200
gcatctgcca gagaaggaag aaatgatgaa aatcaaaaga aaacgtcaca acagtctttg
      1210       1220       1230       1240       1250       1260
ccagtctccg tcaagaatgc ttccccgctg aaaaaatcag atgctaccat tgagttggat
      1270       1280       1290       1300       1310       1320
agagatgaac ctaaaaatcc tgatgaaaat attgaagtat atatagatga aaggggacgt
      1330       1340       1350       1360       1370       1380
tttagaataa ggaacagaca catgggaatc caaatgacac gtgatatcca gaggaactta
      1390       1400       1410       1420       1430       1440
catttgatga aagaaaagga gagaacagct tctggttcta tggctaagaa tgatgaaaca
      1450       1460       1470       1480       1490       1500
ttcagcgcct gggagaactt tcctactgag gaccaatttc ttgaaaaatc acctgttgag
      1510       1520       1530       1540       1550       1560
aaagatgttg tggacctgga gatccagaat gatgattcca tgctgcatcc tccatcttcc
      1570       1580       1590       1600       1610       1620
atagagatat catttgacca tgatggtggt ggaaaagatc tcaatgatga agatgatatg
      1630       1640       1650       1660       1670       1680
tttcttcaat tggcagcggg aggaccagtg acaattagtt ctacagaaaa tgatcctaaa
      1690       1700       1710       1720       1730       1740
gaagacactt caccgtgggc ttctgacagt gattgggaag aagtgcctgt tgaacagaat
      1750       1760       1770       1780       1790       1800
acttctgtct ctaagcttga agcgaattta agcaatcagc atatccccaa ggacattagt
      1810       1820       1830       1840       1850       1860
atcgctgagg gtgtagcatg ggaagaatat agttgtaaaa atgccaataa ctccgtggag
      1870       1880       1890       1900       1910       1920
aatgatacag taacaaagat cacaaaagga tatctggaag aagaagctga tctgcaggag
      1930       1940       1950       1960       1970       1980
gctatcaaga aaagtcttct tgaattacac gataaggaat ccggggatgt ccttgaagaa
      1990       2000       2010       2020       2030       2040
aatcaatcag taagggtaaa tcttgttgtt gacaagccaa gcgaagatag tctttgttct
      2050       2060       2070       2080       2090       2100
agggaaacgg ttggtgaagc tgaggaagag agatttctgg acgaaataac aatcttgaaa
      2110       2120       2130       2140       2150       2160
accagtggtg ctataagtga gcagtccaac acttctgtag cgggcaatgc agatggtcag
      2170       2180       2190       2200       2210       2220
aaagggataa ccaaacaatt tggtacacac ccttcttccg gttctaataa cgttagccat
      2230       2240       2250       2260       2270       2280
gctgtgagca ataaattgtc aaaggtaaaa tcagttatct cacccgagaa agcattaaat
      2290       2300       2310       2320       2330       2340
gttgctagtc aaaaccgcat gctatccacc atggctaaac agcacaatga agaaggttct
      2350       2360       2370       2380       2390       2400
gaaagttttg gtggagaatc tgttaaagtg tctgctatgc ccatagctga tgaggaaata
      2410       2420       2430       2440       2450       2460
actggttttc ttgatgaaaa agataatgct gatggtgaat catctatcat gatggacgat
      2470       2480       2490       2500       2510       2520
aagagagatt atagtagacg taaaatccag agtcttgtca ctgaatcaag ggacccttct
      2530       2540       2550       2560       2570       2580
cgtaatgtcg tcagatcgcg aatagggata ctacatgaca cagattcaca aaatgaaaga
      2590       2600       2610       2620       2630       2640
agggaggaaa ataactctaa cgagcacact ttcaatattg acagttcaac agattttgaa
      2650       2660       2670       2680       2690       2700
gagaaaggcg tgcctgttga attttcagag gcaaatatag aggaggaaat tcgagttctc
      2710       2720       2730       2740       2750       2760
gaccaagaat tcgtaagttt aggtgatgaa cagagaaaac ttgagcggaa tgctgaatct
      2770       2780       2790       2800       2810       2820
gtgagcagtg agatgtttgc agaatgccag gagctactcc aaatttttgg cataccgtac
      2830       2840       2850       2860       2870       2880
atcatagctc ccatggaagc agaggcacag tgtgcattta tggaacaatc aaaccttgtt
      2890       2900       2910       2920       2930       2940
gatggcattg tcactgacga ttctgatgta ttcttgtttg gagcaaggag cgtgtacaaa
      2950       2960       2970       2980       2990       3000
aatatatttg atgatcgtaa atatgtggag acatacttta tgaaggacat tgagaaggag
      3010       3020       3030       3040       3050       3060
ttaggcttga gcagagataa aataatccgc atggcaatgc ttctaggaag tgattacaca
      3070       3080       3090       3100       3110       3120
gaaggaatca gtggtattgg tattgtcaat gctattgaag ttgtgactgc ttttcccgag
      3130       3140       3150       3160       3170       3180
gaggatgggc ttcagaaatt tcgtgaatgg gttgaatcac ctgatccaac cattttagga
      3190       3200       3210       3220       3230       3240
aagactgatg caaaaacagg ttcaaaggta aagaagcgtg ggtctgcctc cgtagataat
      3250       3260       3270       3280       3290       3300
aaaggaatca tctcaggtgc ctcgactgat gacaccgaag aaatcaagca aatcttcatg
      3310       3320       3330       3340       3350       3360
gatcagcata gaaaggtaag caagaactgg catattccat tgactttccc tagtgaggct
      3370       3380       3390       3400       3410       3420
gttatatcag cctacttaaa tccgcaagtg gatctgtcga ctgagaaatt ctcatggggc
      3430       3440       3450       3460       3470       3480
aaacctgatc tttcagtact tagaaagcta tgctgggaaa agtttaattg gaacggcaag
      3490       3500       3510       3520       3530       3540
aaaacagatg aactactact accagtcttg aaggagtatg aaaagcgcga gacgcaactt
      3550       3560       3570       3580       3590       3600
cggattgaag ctttctattc ctttaatgaa agatttgcaa agatccgtag taaaagaatc
      3610       3620       3630       3640       3650       3660
aacaaagctg tcaaaggaat tggtggaggt ctgtcgtcag atgtggccga tcatactctc
      3670       3680       3690       3700       3710       3720
caggaaggtc caagaaaacg aaataagaaa aaagttgctc ctcatgaaac tgaagataac
      3730       3740       3750       3760       3770       3780
aacacttcag acaaagattc acctatagcc aatgagaaag tgaaaaacaa aaggaagcgc
      3790       3800       3810       3820       3830       3840
ttagaaaaac catctagtag tagaggtaga ggcagagccc agaaaagagg acgaggaaga
      3850       3860       3870       3880       3890       3900
ggaagagtcc aaaaagatct ccttgagcta tccgacggca gttctgatga tgatgatgac
      3910       3920       3930       3940       3950       3960
gatgacaagg tagtggaatt ggaggcaaaa ccggccaatc ttcaaaaatc aacacgatct
      3970       3980       3990       4000       4010       4020
cggaatcctg tgatgtacag tgcaaaagaa gatgatgaat tggacgagtc aagaagcaat
      4030       4040       4050       4060       4070       4080
gaaggatctc cgagtgagaa tttcgaagag gttgacgaag gcagaatagg aaatgatgat
      4090       4100       4110       4120       4130       4140
tctgtagatg catcaatcaa cgactgtcct tccgaagact acattcaaac gggaggtggg
      4150       4160       4170       4180       4190       4200
ttctgtgcag atgaagctga tgagattgga gatgctcatt tggaagataa agctaccgat
      4210       4220       4230       4240       4250       4260
gattacagag tgatcggtgg cggattctgt gttgatgaag atgaaacagc tgaggaaaac
      4270       4280       4290       4300       4310       4320
acaatggatg atgatgcaga aattttaaag atggagagtg aagaacaacg aaagaaaggt
      4330       4340       4350       4360       4370       4380
aaacgtcgaa acgaagaaga tgcatcattg gatgagaatg ttgacattca ttttgggaat
      4390       4400       4410       4420       4430       4440
tcttcagctg gaggattaag tgcgatgcct ttcttgaaga gaaagaagag aaaaaactga

Last modification date: Oct. 2, 2011