Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: Cullin-4


DESCRIPTION:
Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4-DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquitination and subsequent degradation of AKIN10. Component of the CUL4-RBX1-DDB1-DWA1/DWA2 E3 ubiquitin-protein ligase complex that acts as negative regulator in abscisic acid (ABA) signaling and may target ABI5 for degradation.

STRUCTURE SIMILARITY:
Belongs to the cullin family.


POST-TRANSLATIONAL MODIFICATION:
Neddylated (rubylated). Deneddylated via its interaction with the COP9 signalosome (CSN) complex.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSLPTKRSTF SAASASDDSS YSSPPMKKAK NDLHHSPQHP NTADKVVGFH MEEDPTPAAA
        70         80         90        100        110        120
NLSRKKATLP QPTKKFVIKL NKAKPTLPTN FEENTWEKLQ SAIRAIFLKK KISFDLESLY
       130        140        150        160        170        180
QAVDNLCLHK LDGKLYDQIE KECEEHISAA LQSLVGQNTD LTVFLSRVEK CWQDFCDQML
       190        200        210        220        230        240
MIRSIALTLD RKYVIQNPNV RSLWEMGLQL FRKHLSLAPE VEQRTVKGLL SMIEKERLAE
       250        260        270        280        290        300
AVNRTLLSHL LKMFTALGIY MESFEKPFLE GTSEFYAAEG MKYMQQSDVP EYLKHVEGRL
       310        320        330        340        350        360
HEENERCILY IDAVTRKPLI TTVERQLLER HILVVLEKGF TTLMDGRRTE DLQRMQTLFS
       370        380        390        400        410        420
RVNALESLRQ ALSSYVRKTG QKIVMDEEKD KDMVQSLLDF KASLDIIWEE SFYKNESFGN
       430        440        450        460        470        480
TIKDSFEHLI NLRQNRPAEL IAKFLDEKLR AGNKGTSEEE LESVLEKVLV LFRFIQGKDV
       490        500        510        520        530        540
FEAFYKKDLA KRLLLGKSAS IDAEKSMISK LKTECGSQFT NKLEGMFKDI ELSKEINESF
       550        560        570        580        590        600
KQSSQARTKL PSGIEMSVHV LTTGYWPTYP PMDVKLPHEL NVYQDIFKEF YLSKYSGRRL
       610        620        630        640        650        660
MWQNSLGHCV LKADFSKGKK ELAVSLFQAV VLMLFNDAMK LSFEDIKDST SIEDKELRRT
       670        680        690        700        710        720
LQSLACGKVR VLQKNPKGRD VEDGDEFEFN DEFAAPLYRI KVNAIQMKET VEENTSTTER
       730        740        750        760        770        780
VFQDRQYQID AAIVRIMKTR KVLSHTLLIT ELFQQLKFPI KPADLKKRIE SLIDREYLER
       790
EKSNPQIYNY LA    

Encoded by CUL4 gene


OTHER NAME(S):
ATCUL4
CUL4
cullin4
MDE13.3
MDE13_3


Nucleic acid sequence

        10         20         30         40         50         60
atgtctcttc ctaccaaacg ctctactttc tccgccgctt ctgcctccga cgactcttct
        70         80         90        100        110        120
tactcttctc ctccgatgaa aaaggccaaa aacgacctcc accattcccc tcaacaccct
       130        140        150        160        170        180
aataccgccg acaaggttgt tggctttcat atggaggaag atccaactcc cgccgccgct
       190        200        210        220        230        240
aatctctctc ggaagaaagc tacacttccg caacctacta agaagtttgt aatcaagctc
       250        260        270        280        290        300
aataaagcca aaccaactct accaacaaac tttgaggaga atacatggga gaagttgcag
       310        320        330        340        350        360
tcagctatca gagctatatt cctcaaaaaa aaaatttcgt ttgacctcga gagcctttac
       370        380        390        400        410        420
caggctgttg ataacctttg cttgcataag ttggatggaa agctttatga ccagattgag
       430        440        450        460        470        480
aaggagtgtg aagaacacat ctctgcagct ttgcaatctt tagttgggca gaacactgat
       490        500        510        520        530        540
ctgactgttt tcttgtcacg tgttgagaaa tgctggcaag acttttgtga ccagatgctc
       550        560        570        580        590        600
atgattcgta gtatagcctt gactctggat aggaagtatg tgatacagaa tccaaatgta
       610        620        630        640        650        660
cgttcattat gggagatggg tttgcagctt ttccggaagc atctttctct ggcccctgaa
       670        680        690        700        710        720
gttgagcaga ggacggttaa aggtctctta agtatgattg aaaaagaaag gttagcagaa
       730        740        750        760        770        780
gctgttaata ggactctact aagccatctt ttgaagatgt ttactgcact gggaatttat
       790        800        810        820        830        840
atggaaagct ttgagaaacc tttccttgaa gggacctctg aattttatgc cgctgaagga
       850        860        870        880        890        900
atgaaataca tgcagcagtc tgacgttccg gagtacctga agcatgttga gggaaggttg
       910        920        930        940        950        960
catgaagaga atgagagatg catactctac atagatgcag taaccaggaa accattgatc
       970        980        990       1000       1010       1020
acaactgttg aaaggcaact tctcgaacgt catatacttg ttgttcttga aaagggtttt
      1030       1040       1050       1060       1070       1080
acaacattaa tggatggacg tcgtacggag gaccttcaga ggatgcaaac cttgttttct
      1090       1100       1110       1120       1130       1140
agggtcaatg cacttgagtc tctgaggcag gcgctaagtt catatgttcg gaaaactggg
      1150       1160       1170       1180       1190       1200
cagaagattg ttatggatga agagaaagac aaagatatgg tacaatcact gttggacttc
      1210       1220       1230       1240       1250       1260
aaggcttctc ttgacataat atgggaagag agcttttaca agaacgaatc atttggtaac
      1270       1280       1290       1300       1310       1320
acaatcaaag attcgtttga gcatctgatt aatcttcgac agaaccggcc agctgagctt
      1330       1340       1350       1360       1370       1380
attgccaagt ttttggacga gaaactccgt gctgggaata agggtacttc tgaagaagaa
      1390       1400       1410       1420       1430       1440
ttggagagtg ttcttgaaaa agtcttggtt ttgttcagat ttatccaggg taaagatgtg
      1450       1460       1470       1480       1490       1500
ttcgaagcat tttacaaaaa ggatcttgcg aagagactcc tgttgggaaa gagtgcttca
      1510       1520       1530       1540       1550       1560
atcgatgctg agaaatccat gatctctaag cttaagactg agtgtggtag ccagtttaca
      1570       1580       1590       1600       1610       1620
aacaagctcg aagggatgtt caaggatatt gaattgtcaa aggaaatcaa cgagtcattc
      1630       1640       1650       1660       1670       1680
aaacaatctt cccaggccag aacaaaactg ccatcgggaa ttgagatgag tgtccacgtt
      1690       1700       1710       1720       1730       1740
ttaacaacag ggtactggcc aacatatccg cctatggatg ttaagcttcc tcatgaacta
      1750       1760       1770       1780       1790       1800
aatgtctatc aggatatctt caaagagttc tatttaagca agtacagtgg taggaggtta
      1810       1820       1830       1840       1850       1860
atgtggcaaa attcattagg ccactgtgtt ttaaaggcag atttctccaa aggtaaaaag
      1870       1880       1890       1900       1910       1920
gagctggctg tttccctgtt tcaggctgtt gtgttaatgt tatttaacga tgcaatgaaa
      1930       1940       1950       1960       1970       1980
cttagctttg aagacattaa agattccacc agcatagagg acaaggagct gaggaggact
      1990       2000       2010       2020       2030       2040
ttgcagtcgc ttgcttgtgg gaaagtccgt gtcctgcaga agaatcctaa gggaagagat
      2050       2060       2070       2080       2090       2100
gtagaagacg gtgatgaatt tgaatttaat gatgagtttg cagctccgct gtatcgcatt
      2110       2120       2130       2140       2150       2160
aaggtaaatg cgatccagat gaaagagaca gtagaggaga acacaagtac aacggaaaga
      2170       2180       2190       2200       2210       2220
gtattccagg accgacaata ccagatcgat gcagccattg ttcgtattat gaagacaaga
      2230       2240       2250       2260       2270       2280
aaagtcttga gccatactct tctaatcact gagctcttcc aacagctcaa attcccgata
      2290       2300       2310       2320       2330       2340
aagcctgctg atctgaagaa gaggattgag agcttgatcg atcgagaata tttggagagg
      2350       2360       2370
gaaaaaagca accctcagat atacaattat cttgcttag  

Last modification date: Oct. 2, 2011