Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Cullin-4


DESCRIPTION:
Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.

STRUCTURE SIMILARITY:
Belongs to the cullin family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MPPEAKRIVV KGFDPRKSRQ RQETYYVTMI DRLNMALQVV MAGLGLKTGY QELYSGVENL
        70         80         90        100        110        120
TRADQASRCF NILQHHMSSG IQLLKDSAES FIQLEGTETD TNACTVVVGC WNKWLERVEI
       130        140        150        160        170        180
VQNIFYYMDK TFLSHHPDYP TIEELSLSLF REKLMAVKNI QIPFLNSLLQ SFENLHSSKS
       190        200        210        220        230        240
TDHAYLQDAM LMLHRTEMYS SVFVPMYLVM LSRFYDTESS QKIQELPLEE YLEYAMSSLE
       250        260        270        280        290        300
REDAYVEKFD IVRDKKSIRE TVQRCLITSH LDTLTKGISQ FIEKRDAHSC KLLYALLQFN
       310        320        330        340        350        360
HETEYLIQPW SDCLVDVGFK LVNDESKDDT LVQELLSFHK FLQVVVDESF LHDETLSYAM
       370        380        390        400        410        420
RKAFETFING AKGSQREAPA RLIAKYIDYL LRVGEQASGG KPLKEVFSEI LDLFRYIASK
       430        440        450        460        470        480
DIFEAYYKLD IAKRLLLNKS ASAQNELMLL DMLKKTCGSQ FTHSLEGMFR DVNISKEFTS
       490        500        510        520        530        540
SFRHSKAAHN LHRDLYVNVL SQAYWPSYPE SHIRLPDDMQ QDLDCFEKFY LSKQVGKKIS
       550        560        570        580        590        600
WYASLGHCIV KARFPLGNKE LSISLFQACV LLQFNNCLGG EGISYQDLKK STELSDIDLT
       610        620        630        640        650        660
RTLQSLSCAR IRPLVMVPKS KKPSPDTMFY VNEKFTDKLY RVKINQIYLK EERQENSDVQ
       670        680        690        700        710        720
EQVVRDRQFE LQASIVRVMK QKEKMKHDDL VQYVINNVKD RGIPLVSDVK TAIEKLLEKE
       730
YLEREDNDIY TYVT    

Encoded by pcu4 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgcctccag aagcaaaacg tatcgtggtt aaaggctttg acccacgaaa gtcgaggcaa
        70         80         90        100        110        120
agacaagaga cctactatgt gacgatgata gatcgtttga acatggcttt gcaagtagtg
       130        140        150        160        170        180
atggccggtt taggcttaaa aacaggttac caagagttat attcgggagt cgaaaattta
       190        200        210        220        230        240
acaagagcgg atcaagcatc tcggtgcttt aacatcctac aacatcatat gtcttcagga
       250        260        270        280        290        300
atccagcttt taaaggattc tgcggagtct tttatacagc ttgaagggac tgaaacagac
       310        320        330        340        350        360
actaatgcat gcaccgtagt agtagggtgt tggaacaaat ggttggaaag agtcgagatt
       370        380        390        400        410        420
gttcaaaaca tattctatta catggacaaa acatttcttt ctcaccatcc agattacccg
       430        440        450        460        470        480
acaatcgaag agctgtctct gtcacttttt cgtgaaaagt tgatggcagt caaaaacata
       490        500        510        520        530        540
caaattccct ttttgaactc tcttctccaa agctttgaaa atttacatag ctctaaaagc
       550        560        570        580        590        600
actgatcacg cctatttaca ggatgcgatg ttaatgctac atcgcacgga aatgtatagc
       610        620        630        640        650        660
tctgtgtttg ttcccatgta cttagttatg ctaagccgtt tttatgatac ggagtctagc
       670        680        690        700        710        720
caaaaaattc aagagctgcc tttggaagag tacttggaat atgcgatgag ttcgcttgag
       730        740        750        760        770        780
cgggaggatg cctacgttga aaagtttgat attgtgcgcg ataaaaagtc cattcgagag
       790        800        810        820        830        840
actgttcaaa ggtgtctaat tacttcacat cttgacacac tcacaaaggg tataagtcag
       850        860        870        880        890        900
ttcattgaaa aaagggatgc ccattcttgt aaactactgt atgcattact gcaattcaat
       910        920        930        940        950        960
catgaaaccg aatatttaat tcagccctgg tcggattgct tagtggacgt tggtttcaag
       970        980        990       1000       1010       1020
ctcgttaacg atgaatcaaa ggatgatact ttggttcaag agctgttatc gttccacaaa
      1030       1040       1050       1060       1070       1080
ttcttacaag tcgtggtgga tgaaagtttc cttcatgatg aaaccctttc gtatgccatg
      1090       1100       1110       1120       1130       1140
cgaaaagcct tcgagacgtt cattaatggg gcaaagggat ctcaaagaga agctccagct
      1150       1160       1170       1180       1190       1200
aggcttattg caaaatacat tgattatttg ctacgagttg gcgaacaggc ttcagggggt
      1210       1220       1230       1240       1250       1260
aagcctctga aagaagtatt ttcggaaatt ttggatcttt tccgctacat cgctagtaaa
      1270       1280       1290       1300       1310       1320
gatatctttg aggcgtatta caagctggac attgcaaaac ggcttctcct taataaatct
      1330       1340       1350       1360       1370       1380
gcaagtgcgc aaaatgaatt aatgcttctg gatatgctta agaaaacctg cggtagtcag
      1390       1400       1410       1420       1430       1440
tttactcact ctttggaggg tatgtttcga gacgttaaca tttcaaaaga atttacttct
      1450       1460       1470       1480       1490       1500
tcttttcgtc actcaaaggc tgctcataac cttcatagag atttgtatgt taacgtcttg
      1510       1520       1530       1540       1550       1560
tcccaagctt actggccctc ttatccagaa tcacatatcc ggcttccaga tgatatgcaa
      1570       1580       1590       1600       1610       1620
caggatttgg attgttttga aaaattttac ctttcaaagc aggttgggaa aaaaatcagt
      1630       1640       1650       1660       1670       1680
tggtacgctt cgctaggaca ttgcatcgta aaagcccgat ttccactggg caataaggaa
      1690       1700       1710       1720       1730       1740
ctaagtatat cgcttttcca agcctgtgtc ttacttcaat tcaacaattg tttgggtgga
      1750       1760       1770       1780       1790       1800
gaagggattt cgtatcaaga tttgaaaaaa tctacagagc tctctgatat cgatttgact
      1810       1820       1830       1840       1850       1860
cgtacattac agtccttgag ttgtgctcgc attcggccat tagtgatggt tcccaaaagc
      1870       1880       1890       1900       1910       1920
aaaaaaccca gtccagacac catgttttat gttaatgaaa agtttacaga taagttatat
      1930       1940       1950       1960       1970       1980
cgtgtaaaaa ttaaccaaat ttatttaaag gaagagcggc aagaaaattc tgatgttcaa
      1990       2000       2010       2020       2030       2040
gaacaagtag tgagagatcg acagtttgag ttgcaagcca gtatcgttcg agtaatgaaa
      2050       2060       2070       2080       2090       2100
caaaaggaaa aaatgaagca tgacgattta gttcaatacg ttataaacaa tgttaaggat
      2110       2120       2130       2140       2150       2160
cggggaatac ccttggtgtc tgatgtgaaa actgccattg aaaaactact agagaaagag
      2170       2180       2190       2200
tatctagaac gcgaggataa tgatatttat acatatgtca cctaa 

Last modification date: Oct. 2, 2011