Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: Protein DAMAGED DNA-BINDING 2


DESCRIPTION:
May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4 (By similarity). Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair.

STRUCTURE SIMILARITY:
Contains 1 CCHC-type zinc finger.
Contains 5 WD repeats.
Belongs to the WD repeat DDB2/WDR76 family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSSTRSRRKR DPEIVIARDT DSELSSSEEE EEEEDNYPFS ESEEEDEAVK NGGKIELEKN
        70         80         90        100        110        120
KAKGKAPITV KLIKKVCKVC KQPGHEAGFK GATYIDCPMK PCFLCKMPGH TTMSCPHRVV
       130        140        150        160        170        180
TDHGILPTSH RNTKNPIDFV FKRQLQPRIP PIKPKYVIPD QVHCAVIRYH SRRVTCLEFH
       190        200        210        220        230        240
PTKNNILLSG DKKGQIGVWD FGKVYEKNVY GNIHSVQVNN MRFSPTNDDM VYSASSDGTI
       250        260        270        280        290        300
GYTDLETGTS STLLNLNPDG WQGANSWKML YGMDINSEKG VVLAADNFGF LHMIDHRTNN
       310        320        330        340        350        360
STGEPILIHK QGSKVCGLDC NPVQPELLLS CGNDHFARIW DMRKLQPKAS LHDLAHKRVV
       370        380        390        400        410        420
NSAYFSPSSG TKILTTCQDN RIRIWDSIFG NLDLPSREIV HSNDFNRHLT PFKAEWDPKD
       430        440        450        460        470        480
TSESLIVIGR YISENYNGTA LHPIDFIDAS NGQLVAEVMD PNITTITPVN KLHPRDDVLA
       490        500        510        520        530        540
SGSSRSLFIW RPQDNTEMVE EKKDKKIIIC YGDSKKKGKK QKRGSDDEDD EDDIFSSKGK
       550
NIKVNKYQAK TTKKTKT    

Encoded by DDB2 gene


OTHER NAME(S):
damaged DNA binding 2
DDB2
MZN1.20
MZN1_20


Nucleic acid sequence

        10         20         30         40         50         60
atgagttcaa cgaggagcag aagaaaaagg gacccagaaa tcgtcatcgc tagagataca
        70         80         90        100        110        120
gattccgagt taagttcgtc agaagaagaa gaagaagagg aagataatta ccctttctcg
       130        140        150        160        170        180
gagtcggagg aggaagatga agcggttaaa aatggaggga aaattgaatt ggagaagaat
       190        200        210        220        230        240
aaagccaaag ggaaagcacc cattaccgtt aagcttatta agaaagtttg caaagtttgt
       250        260        270        280        290        300
aaacagcctg gccatgaagc tggatttaaa ggagcaacgt atatcgattg tcctatgaag
       310        320        330        340        350        360
ccttgcttct tgtgtaaaat gcctggccac accacaatgt cctgtcctca tagagtggtt
       370        380        390        400        410        420
actgaccacg gaatactccc aacttctcat aggaatacaa agaaccctat tgactttgtg
       430        440        450        460        470        480
ttcaagcgcc aactccaacc gagaattcct cctattaaac caaaatatgt gatcccggat
       490        500        510        520        530        540
caagttcatt gtgcagttat tagataccac agcagacgtg ttacatgttt ggagttccat
       550        560        570        580        590        600
ccaacaaaga acaacattct tctctctgga gataagaaag ggcaaattgg agtctgggat
       610        620        630        640        650        660
tttggaaaag tgtatgagaa gaatgtgtat ggaaacatac attctgttca agttaataat
       670        680        690        700        710        720
atgcggttta gtcccacaaa tgatgacatg gtttattctg catcctctga tggaacaatt
       730        740        750        760        770        780
ggttatactg acctggaaac tggaacttca tcaactttgc tgaatctcaa ccctgatgga
       790        800        810        820        830        840
tggcagggcg caaacagttg gaaaatgctg tacggtatgg atataaactc ggagaaaggt
       850        860        870        880        890        900
gtagtgcttg ctgctgataa ttttgggttt cttcacatga tcgatcatcg taccaataac
       910        920        930        940        950        960
agtacgggtg agcctattct gatacacaag caaggaagca aagtttgtgg cctcgactgc
       970        980        990       1000       1010       1020
aaccctgtcc agcctgagct tcttctcagt tgtgggaacg atcattttgc gcgaatctgg
      1030       1040       1050       1060       1070       1080
gatatgcgta aactacaacc taaagcttct cttcatgatc ttgcacacaa acgagtagtc
      1090       1100       1110       1120       1130       1140
aactctgctt acttctctcc atcatcaggc acgaaaatcc tcacgacgtg tcaggacaac
      1150       1160       1170       1180       1190       1200
cgtattcgaa tatgggactc tatcttcggg aacttagatt tgccaagccg agagattgtt
      1210       1220       1230       1240       1250       1260
catagtaatg atttcaatcg gcatttgaca ccattcaaag ctgaatggga ccctaaggat
      1270       1280       1290       1300       1310       1320
acctcggagt cactcatcgt gattggtcgt tacatcagtg aaaactacaa cggaactgct
      1330       1340       1350       1360       1370       1380
cttcacccaa tagatttcat tgatgcaagc aatggacaat tggttgcaga ggttatggat
      1390       1400       1410       1420       1430       1440
ccaaacatca caactattac tccagtcaac aagttgcatc ctcgcgatga tgttttagct
      1450       1460       1470       1480       1490       1500
tcaggaagtt caaggtcgct gttcatttgg aggccacagg ataatacaga gatggttgag
      1510       1520       1530       1540       1550       1560
gagaagaagg ataagaagat tatcatatgt tatggtgaca gcaagaagaa aggaaagaag
      1570       1580       1590       1600       1610       1620
caaaagcgtg gcagcgatga tgaagacgat gaagatgaca tatttagctc taaaggcaaa
      1630       1640       1650       1660       1670
aacataaaag tcaataagta tcaagcaaaa acaaccaaga agacaaaaac ttaa

Last modification date: Oct. 2, 2011