Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: RING-box protein 1a


DESCRIPTION:
Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL1.

STRUCTURE SIMILARITY:
Contains 1 RING-type zinc finger.
Belongs to the RING-box family.


RELATED PATHWAY(S):
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MATLDSDVTM IPAGEASSSV AASSSNKKAK RFEIKKWSAV ALWAWDIVVD NCAICRNHIM
        70         80         90        100        110        120
DLCIECQANQ ASATSEECTV AWEDDQNNCN KYFCILDCSM KDDHLEGVCN HAFHFHCISR
       130        140
WLKTRQVCPL DNSEWEFQKY GH   

Encoded by RBX1 gene


OTHER NAME(S):
ATRBX1
F7C8.160
F7C8_160
HRT1
RBX1
REGULATOR OF CULLINS-1
RING-box 1
RING-BOX 1
ROC1


Nucleic acid sequence

        10         20         30         40         50         60
atggcgactc tagactccga cgttaccatg attcctgccg gagaagcctc cagcagcgta
        70         80         90        100        110        120
gccgcgtcgt cttccaacaa gaaagctaag cgattcgaaa ttaagaagtg gagcgccgtt
       130        140        150        160        170        180
gctctctggg cttgggatat cgttgttgac aactgtgcga tctgcagaaa ccacatcatg
       190        200        210        220        230        240
gatctttgta tcgagtgtca ggctaatcag gccagtgcca caagtgaaga gtgcactgta
       250        260        270        280        290        300
gcttgggagg acgaccaaaa taactgcaat aagtatttct gtattcttga ttgctcaatg
       310        320        330        340        350        360
aaagatgacc acttggaggg ggtttgcaat cacgccttcc actttcactg catcagcaga
       370        380        390        400        410        420
tggctaaaga ctcgtcaagt ttgtccattg gataacagtg agtgggagtt tcagaaatat

ggtcactaa     

Last modification date: Oct. 2, 2011