Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: Cyclin-dependent kinase D-2


DESCRIPTION:
Forms a stable complex with cyclin CYCH1-1 that phosphorylates human CDK2 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.

STRUCTURE SIMILARITY:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.


ENZYME REGULATION:
Activated by phosphorylation by CDKF-1. Down-regulated by phosphorylation by WEE1.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated by CDKF-1 at Ser-162 and Thr-168. Phosphorylated by WEE1 at Tyr-24. Autophosphorylated.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MSKSGDNQPV DRYLRRQILG EGTYGVVYKA TDTKTGKTVA VKKIRLGNQK EGVNFTALRE
        70         80         90        100        110        120
IKLLKELNHP HIVELIDAFP HDGSLHLVFE YMQTDLEAVI RDRNIFLSPG DIKSYMLMTL
       130        140        150        160        170        180
KGLAYCHKKW VLHRDMKPNN LLIGENGLLK LADFGLARLF GSPNRRFTHQ VFATWYRAPE
       190        200        210        220        230        240
LLFGSRQYGA GVDVWAAGCI FAELLLRRPF LPGSTEIDQL GKIFQAFGTP VPSQWSDMIY
       250        260        270        280        290        300
LPDYMEFSYT PAPPLRTIFP MASDDALDLL AKMFIYDPRQ RITIQQALDH RYFSSSPSPT
       310        320        330        340
EPGKLQIPAS KGDALEPKAS EQNQHGNSPA VLSPPGKMRR VMGPEGFT 

Encoded by CAK4 gene


OTHER NAME(S):
AT;CDKD;2
CAK4
CAK4AT
CDK-activating kinase 4
CDK-ACTIVATING KINASE 4
CDKD1;2
CDKD;2
CYCLIN-DEPENDENT KINASE D1;2
F4N21.12
F4N21_12


Nucleic acid sequence

        10         20         30         40         50         60
atgtcgaaat ccggcgataa tcaaccagtt gatagatacc tccgccgtca aatcctcgga
        70         80         90        100        110        120
gaaggaacat acggtgtcgt ttacaaagcc accgacacaa agactgggaa aactgtagca
       130        140        150        160        170        180
gtgaagaaga taagattagg aaaccaaaag gaaggagtaa atttcacagc tttaagagaa
       190        200        210        220        230        240
atcaagctac taaaagagct gaatcatcca catatcgttg aactcattga tgctttccct
       250        260        270        280        290        300
cacgatggaa gtttgcatct agtttttgag tatatgcaaa cagatttaga agcagtgatt
       310        320        330        340        350        360
cgtgatcgta atatcttttt atctcctggt gatattaagt cttatatgtt gatgactttg
       370        380        390        400        410        420
aagggtttag cttattgtca taagaaatgg gttcttcaca gggatatgaa gccgaataat
       430        440        450        460        470        480
ttgttgattg gagagaatgg tttgttgaag ttggctgatt ttggtttggc gaggttgttt
       490        500        510        520        530        540
gggagtccga atcggaggtt tactcatcag gtatttgcta catggtacag agcgcctgag
       550        560        570        580        590        600
ttactgtttg ggagtcgaca gtatggagca ggagttgatg tttgggctgc aggctgtatt
       610        620        630        640        650        660
tttgctgagt tactacttcg tagaccattt cttccgggtt ctactgagat tgatcaactt
       670        680        690        700        710        720
ggaaagatct ttcaagcgtt tggtactcca gtaccttccc aatggtctga catgatctat
       730        740        750        760        770        780
ctcccagact acatggaatt ctcctataca cccgctccac cattacgtac cattttccct
       790        800        810        820        830        840
atggcaagtg atgacgcttt ggatcttcta gcaaaaatgt tcatctacga cccacgtcaa
       850        860        870        880        890        900
aggatcacaa tacaacaagc tttagaccac aggtatttct cgtcttctcc atcaccaact
       910        920        930        940        950        960
gagccaggga agcttcagat tccagcttcc aaaggagacg cactcgaacc aaaggcctcc
       970        980        990       1000       1010       1020
gagcaaaacc aacatggaaa tagcccagcg gtactgtctc ctcctggtaa aatgaggaga
      1030       1040
gtgatgggtc ctgaaggatt cacttga   

Last modification date: Oct. 2, 2011