Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: Cyclin-dependent kinase D-3


DESCRIPTION:
May form a stable complex with cyclin CYCH1-1 that phosphorylates human CDK2 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II.

STRUCTURE SIMILARITY:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.


ENZYME REGULATION:
Activated by phosphorylation by CDKF-1.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated by CDKF-1 at Ser-161 and Thr-167. Phosphorylated at Tyr-23 by WEE1. Autophosphorylated.


RELATED PATHWAY(S):
nucleotide excision repair (NER)
transcription factors


Amino acids sequence

        10         20         30         40         50         60
MPEQPKKVAD RYLKQEVLGQ GTYGVVFKAT DTKTEQTVAI KKIRLGKQRE GVNITALREI
        70         80         90        100        110        120
KMLKELKHPH IILLIDAFPH KENLHLVFEF METDLEAVIR DSNIFLSPAD IKSYLLMTFK
       130        140        150        160        170        180
GLAYCHDKWV LHRDMKPNNL LIGVDGQLKL ADFGLARIFG SPNRKFTHQV FARWYRAPEL
       190        200        210        220        230        240
LFGAKQYGAA VDVWAVACIF AELLLRRPFL QGNSDIDQLS KIFAAFGTPK ADQWPDLTKL
       250        260        270        280        290        300
PDYVEYQFVP APSLRSLFPA VSDDALDLLS KMFTYDPKAR ISIKQALEHR YFTSAPAPTD
       310        320        330        340        350        360
PAKLPKPVPK QDGKSSYGKH EAITVQSPPR KLRRVMPERG RVDSLKSHVD KDQQAPMSLD
       370        380        390
FTILAERPPN RPTITSADRS HLKRKLDLEF Q  

Encoded by CDKD1;3 gene


OTHER NAME(S):
AT;CDCKD;3
CAK2AT
CDKD1;3
cyclin-dependent kinase D1;3
CYCLIN-DEPENDENT KINASE D1;3
T10F20.5
T10F20_5


Nucleic acid sequence

        10         20         30         40         50         60
atgccggagc agccaaagaa agttgctgat aggtatctca agcaagaggt tcttgggcaa
        70         80         90        100        110        120
ggtacctatg gagtcgtctt caaagccact gatactaaga cggaacaaac tgtagcaatt
       130        140        150        160        170        180
aagaagataa ggcttggtaa acaaagagaa ggtgtaaata ttacagctct cagagaaatc
       190        200        210        220        230        240
aaaatgctca aagagctaaa gcatcctcat attattctgc tcattgatgc atttcctcac
       250        260        270        280        290        300
aaggaaaact tgcatcttgt ctttgagttc atggagactg acctcgaagc agttattcgc
       310        320        330        340        350        360
gattctaaca ttttcctctc acccgccgac attaaatcct acctcctaat gacatttaaa
       370        380        390        400        410        420
ggacttgctt attgccacga taaatgggtt ttgcacaggg atatgaagcc aaataacttg
       430        440        450        460        470        480
ttaataggag ttgatggaca gcttaagctt gcagattttg gcttagcacg tatatttggt
       490        500        510        520        530        540
agtccaaatc gtaagtttac ccaccaggtg tttgctagat ggtacagagc accagaactt
       550        560        570        580        590        600
ttgtttggtg caaaacaata tggtgctgca gttgatgttt gggccgttgc ctgcatattc
       610        620        630        640        650        660
gccgaacttc tactacgcag accatttctt cagggaaaca gtgatattga tcaattaagc
       670        680        690        700        710        720
aaaatatttg ctgcttttgg gacaccaaaa gcagatcagt ggccggattt aacaaagctt
       730        740        750        760        770        780
ccagattatg tagagtatca atttgtccct gcaccgtctc tacgttcttt attcccagca
       790        800        810        820        830        840
gttagtgatg atgctctcga cttgttgtcc aaaatgttta cctatgaccc aaaggctaga
       850        860        870        880        890        900
atttccatta agcaggctct agaacacagg tacttcactt ctgcacctgc tcctactgac
       910        920        930        940        950        960
ccggctaagc tcccaaagcc cgttcctaag caggatggta aatcatctta cggtaaacat
       970        980        990       1000       1010       1020
gaggccatta cagtgcaatc accaccacgt aagcttagaa gagtgatgcc tgagcgtggg
      1030       1040       1050       1060       1070       1080
agggttgata gtttgaagtc tcatgttgac aaggatcaac aagcacccat gtcattagat
      1090       1100       1110       1120       1130       1140
tttaccatcc tcgctgagcg acctccaaac aggccaacaa tcaccagtgc tgatagatct
      1150       1160       1170
catctgaaga ggaaactcga tcttgagttc cagtaa  

Last modification date: Oct. 2, 2011