Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: Formamidopyrimidine-DNA glycosylase


MISCELLANEOUS:
damaged DNA binding, oxidized purine base lesion DNA N-glycosylase activity, zinc ion binding


PROTEIN TYPE(S):
DNA N-glycosylase/AP-lyase


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MPELPEVEAA RRAIEENCLG KKIKRVIIAD DNKVIHGISP SDFQTSILGK TIISARRKGK
        70         80         90        100        110        120
NLWLELDSPP FPSFQFGMAG AIYIKGVAVT KYKRSAVKDS EEWPSKYSKF FVELDDGLEL
       130        140        150        160        170        180
SFTDKRRFAK VRLLANPTSV SPISELGPDA LLEPMTVDEF AESLAKKKIT IKPLLLDQGY
       190        200        210        220        230        240
ISGIGNWIAD EVLYQARIHP LQTASSLSKE QCEALHTSIK EVIEKAVEVD ADSSQFPSYW
       250        260        270        280        290        300
IFHNREKKPG KAFVDGKKID FITAGGRTTA YVPELQKLYG KDAEKAAKVR PAKRGVKPKE
       310        320        330        340        350        360
DDGDGEEDEQ ETEKEDESAK SKKGQKPRGG RGKKPASKTK TEESDDDGDD SEAEEEVVKP
       370        380        390
KGRGTKPAIK RKSEEKATSQ AGKKPKGRKS   

Encoded by MMH-1 gene


OTHER NAME(S):
A. THALIANA FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 1
ATFPG-1
ATFPG-2
ATMMH-1
ATMMH-2
F6D8.37
F6D8_37
FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 1
FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE 2
FPG-1
FPG-2
MMH-1
MMH-2
MUTM homolog-1


DESCRIPTION:
Encodes one of the splice variants of Arabidopsis thaliana MutM homolog. Encodes a formamidopyrimidine-DNA glycosylase that has abasic lyase activity and is able to nick double- stranded oligonucleotides containing 8-oxo-7,8-dihydroguanine (8-oxoG) in vitro.


Nucleic acid sequence

        10         20         30         40         50         60
atgccggagc ttccagaggt cgaggcggcg aggagagcaa tagaagaaaa ttgtcttgga
        70         80         90        100        110        120
aaaaagatta agcgagtcat tatcgccgac gacaacaaag tgatccatgg aatctcgccg
       130        140        150        160        170        180
tccgatttcc agacctcaat cctcggaaaa accatcatct ctgctcgtag aaagggcaaa
       190        200        210        220        230        240
aacctctggc tcgaattaga ttccccgcca tttccttctt ttcaattcgg tatggctggt
       250        260        270        280        290        300
gctatttata tcaaaggcgt tgcagttact aagtataaga ggtctgctgt aaaggactca
       310        320        330        340        350        360
gaggagtggc catctaagta ttcaaagttc ttcgtcgagc ttgatgatgg tctggagctt
       370        380        390        400        410        420
tcatttactg ataagaggag atttgccaaa gttcgacttc tagcaaatcc tacttctgtg
       430        440        450        460        470        480
agtccaatat cagagcttgg tcctgatgca ttgttggagc ctatgacagt tgatgaattt
       490        500        510        520        530        540
gcagaaagct tagctaaaaa gaaaataacc ataaaacctc tcctacttga tcagggatat
       550        560        570        580        590        600
atttcaggta ttgggaattg gatcgctgat gaagtgctgt accaagccag aatccacccg
       610        620        630        640        650        660
ttgcagactg cttctagcct ctccaaagag caatgtgaag ctttgcacac atccatcaaa
       670        680        690        700        710        720
gaggtgatag aaaaagctgt ggaagttgat gcagacagta gtcagtttcc tagttactgg
       730        740        750        760        770        780
atttttcata atagggaaaa gaagccagga aaggcctttg ttgatgggaa gaagattgat
       790        800        810        820        830        840
ttcattactg ctggtggaag gacaacagct tatgttccag aactgcagaa actttatggg
       850        860        870        880        890        900
aaagacgcag agaaagcagc caaggttaga ccggctaaac gaggtgtgaa acccaaagaa
       910        920        930        940        950        960
gacgatggag atggggaaga agatgaacaa gaaactgaga aagaagatga gagtgctaaa
       970        980        990       1000       1010       1020
tcgaagaaag gacagaaacc cagaggtggt cgtggtaaga agcctgcatc gaagacaaaa
      1030       1040       1050       1060       1070       1080
acagaagaga gcgacgatga tggagatgat agcgaggctg aagaagaagt tgtgaaaccc
      1090       1100       1110       1120       1130       1140
aaaggccgtg gtacaaagcc tgcaataaag aggaagtctg aagagaaagc tactagccaa
      1150       1160       1170
gctggtaaga agccaaaagg aagaaaaagt tga  

Last modification date: Feb. 26, 2012