Homo sapiens L. (human) [HSA]

FULL NAME: Replication protein A 30 kDa subunit


DESCRIPTION:
Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

RELATED PATHWAY(S):
DNA replication
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MSKSGFGSYG SISAADGASG GSDQLCERDA TPAIKTQRPK VRIQDVVPCN VNQLLSSTVF
        70         80         90        100        110        120
DPVFKVRGII VSQVSIVGVI RGAEKASNHI CYKIDDMTAK PIEARQWFGR EKVKQVTPLS
       130        140        150        160        170        180
VGVYVKVFGI LKCPTGTKSL EVLKIHVLED MNEFTVHILE TVNAHMMLDK ARRDTTVESV
       190        200        210        220        230        240
PVSPSEVNDA GDNDESHRNF IQDEVLRLIH ECPHQEGKSI HELRAQLCDL SVKAIKEAID
       250        260
YLTVEGHIYP TVDREHFKSA D   

Encoded by RPA4 gene

FULL NAME: replication protein A4, 30kDa


OTHER NAME(S):
HSU24186
MGC120333
MGC120334


DESCRIPTION:
This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atgagtaaga gtgggtttgg gagctatggc agcatttctg ctgctgatgg agcgagtgga
        70         80         90        100        110        120
ggcagtgacc aactgtgtga gagagatgca actcctgcta ttaagaccca aagacctaag
       130        140        150        160        170        180
gtccgaattc aggacgttgt accgtgtaat gtgaaccagc ttctcagctc tactgtgttt
       190        200        210        220        230        240
gaccctgtgt tcaaggttag gggaattata gtttcccagg tctccatcgt gggggtaatc
       250        260        270        280        290        300
agaggggcag agaaggcttc aaatcacatt tgttacaaaa ttgatgatat gaccgcgaaa
       310        320        330        340        350        360
ccaatcgagg cccgacagtg gtttggtaga gagaaagtca agcaggtgac tccattgtca
       370        380        390        400        410        420
gtcggagtat atgtcaaagt gtttggtatc ctcaaatgtc ccacgggaac aaagagcctt
       430        440        450        460        470        480
gaggtattga aaattcatgt cctagaggac atgaacgagt tcaccgtgca tattctggaa
       490        500        510        520        530        540
acggtcaatg cacacatgat gctggataaa gcccgtcgtg ataccactgt agaaagtgtg
       550        560        570        580        590        600
cctgtgtctc catcagaagt gaatgatgct ggggataacg atgagagtca ccgcaatttc
       610        620        630        640        650        660
atccaggacg aagtgctgcg tttgattcat gagtgtcctc atcaggaagg gaagagcatc
       670        680        690        700        710        720
catgagctcc gggctcagct ctgcgacctt agcgtcaagg ccatcaagga agcgattgat
       730        740        750        760        770        780
tatctgaccg ttgagggcca catctatccc actgtggatc gggagcattt taagtctgct

gattga     

Last modification date: Oct. 2, 2011