Homo sapiens L. (human) [HSA]

FULL NAME: DNA ligase 3


DESCRIPTION:
Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.

STRUCTURE SIMILARITY:
Contains 1 PARP-type zinc finger.
Contains 1 BRCT domain.
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


PROTEIN TYPE(S):
DNA ligase


RELATED PATHWAY(S):
microhomology-mediated end-joining (MMEJ)
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MSLAFKIFFP QTLRALSRKE LCLFRKHHWR DVRQFSQWSE TDLLHGHPLF LRRKPVLSFQ
        70         80         90        100        110        120
GSHLRSRATY LVFLPGLHVG LCSGPCEMAE QRFCVDYAKR GTAGCKKCKE KIVKGVCRIG
       130        140        150        160        170        180
KVVPNPFSES GGDMKEWYHI KCMFEKLERA RATTKKIEDL TELEGWEELE DNEKEQITQH
       190        200        210        220        230        240
IADLSSKAAG TPKKKAVVQA KLTTTGQVTS PVKGASFVTS TNPRKFSGFS AKPNNSGEAP
       250        260        270        280        290        300
SSPTPKRSLS SSKCDPRHKD CLLREFRKLC AMVADNPSYN TKTQIIQDFL RKGSAGDGFH
       310        320        330        340        350        360
GDVYLTVKLL LPGVIKTVYN LNDKQIVKLF SRIFNCNPDD MARDLEQGDV SETIRVFFEQ
       370        380        390        400        410        420
SKSFPPAAKS LLTIQEVDEF LLRLSKLTKE DEQQQALQDI ASRCTANDLK CIIRLIKHDL
       430        440        450        460        470        480
KMNSGAKHVL DALDPNAYEA FKASRNLQDV VERVLHNAQE VEKEPGQRRA LSVQASLMTP
       490        500        510        520        530        540
VQPMLAEACK SVEYAMKKCP NGMFSEIKYD GERVQVHKNG DHFSYFSRSL KPVLPHKVAH
       550        560        570        580        590        600
FKDYIPQAFP GGHSMILDSE VLLIDNKTGK PLPFGTLGVH KKAAFQDANV CLFVFDCIYF
       610        620        630        640        650        660
NDVSLMDRPL CERRKFLHDN MVEIPNRIMF SEMKRVTKAL DLADMITRVI QEGLEGLVLK
       670        680        690        700        710        720
DVKGTYEPGK RHWLKVKKDY LNEGAMADTA DLVVLGAFYG QGSKGGMMSI FLMGCYDPGS
       730        740        750        760        770        780
QKWCTVTKCA GGHDDATLAR LQNELDMVKI SKDPSKIPSW LKVNKIYYPD FIVPDPKKAA
       790        800        810        820        830        840
VWEITGAEFS KSEAHTADGI SIRFPRCTRI RDDKDWKSAT NLPQLKELYQ LSKEKADFTV
       850        860        870        880        890        900
VAGDEGSSTT GGSSEENKGP SGSAVSRKAP SKPSASTKKA EGKLSNSNSK DGNMQTAKPS
       910        920        930        940
AMKVGEKLAT KSSPVKVGEK RKAADETLCQ TKRRPASEQR GRTVPAGRR 

Encoded by LIG3 gene

FULL NAME: ligase III, DNA, ATP-dependent


OTHER NAME(S):
LIG2


DESCRIPTION:
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtctttgg ctttcaagat cttctttcca caaaccctcc gtgcactcag ccgaaaagaa
        70         80         90        100        110        120
ctgtgcctat tccgaaaaca tcactggcgt gatgtaagac aattcagcca gtggtcagaa
       130        140        150        160        170        180
acagatctgc ttcatggaca tcccctcttc ctgagaagaa agcctgttct atcattccag
       190        200        210        220        230        240
ggaagccatc taagatcacg tgccacctac cttgttttct tgccagggtt gcatgtggga
       250        260        270        280        290        300
ctctgcagtg gcccctgtga gatggctgag caacggttct gtgtggacta tgccaagcgt
       310        320        330        340        350        360
ggcacagctg gctgcaaaaa atgcaaggaa aagattgtga agggcgtatg ccgaattggc
       370        380        390        400        410        420
aaagtggtgc ccaatccctt ctcagagtct gggggtgata tgaaagagtg gtaccacatt
       430        440        450        460        470        480
aaatgcatgt ttgagaaact agagcgggcc cgggccacca caaaaaaaat cgaggacctc
       490        500        510        520        530        540
acagagctgg aaggctggga agagctggaa gataatgaga aggaacagat aacccagcac
       550        560        570        580        590        600
attgcagatc tgtcttctaa ggcagcaggt acaccaaaga agaaagctgt tgtccaggct
       610        620        630        640        650        660
aagttgacaa ccactggcca ggtgacttct ccagtgaaag gcgcctcatt tgtcaccagt
       670        680        690        700        710        720
accaatcccc ggaaattttc tggcttttca gccaagccca acaactctgg ggaagccccc
       730        740        750        760        770        780
tcgagcccca cccctaagag aagtctgtct tcaagcaaat gtgaccccag gcataaggac
       790        800        810        820        830        840
tgtctgctac gggagtttcg aaagttatgc gccatggtgg ccgataatcc tagctacaac
       850        860        870        880        890        900
acgaagaccc agatcatcca ggacttcctt cggaaaggct cagcaggaga tggtttccac
       910        920        930        940        950        960
ggtgatgtgt acctaacagt gaagctgctg ctgccaggag tcattaagac tgtttacaac
       970        980        990       1000       1010       1020
ttgaacgata agcagattgt gaagcttttc agtcgcattt ttaactgcaa cccagatgat
      1030       1040       1050       1060       1070       1080
atggcacggg acctagagca gggtgacgtg tcagagacaa tcagagtctt ctttgagcag
      1090       1100       1110       1120       1130       1140
agcaagtctt tccccccagc tgccaagagc ctccttacca tccaggaagt ggatgagttc
      1150       1160       1170       1180       1190       1200
cttctgcggc tgtccaagct caccaaggag gatgagcagc aacaggccct acaggacatt
      1210       1220       1230       1240       1250       1260
gcctccaggt gtacagccaa tgaccttaaa tgcatcatca ggttgatcaa acatgatctg
      1270       1280       1290       1300       1310       1320
aagatgaact caggtgcaaa acatgtgtta gacgcccttg accccaatgc ctatgaagcc
      1330       1340       1350       1360       1370       1380
ttcaaagcct cgcgcaacct gcaggatgtg gtggagcggg tccttcacaa cgcgcaggag
      1390       1400       1410       1420       1430       1440
gtggagaagg agccgggcca gagacgagct ctgagcgtcc aggcctcgct gatgacacct
      1450       1460       1470       1480       1490       1500
gtgcagccca tgttggcgga ggcctgcaag tccgttgagt atgcaatgaa gaaatgtccc
      1510       1520       1530       1540       1550       1560
aatggcatgt tctctgagat caagtacgat ggagagcgag tccaggtgca taagaatgga
      1570       1580       1590       1600       1610       1620
gaccacttca gctacttcag ccgcagtctc aagcccgtcc ttcctcacaa ggtggcccac
      1630       1640       1650       1660       1670       1680
tttaaggact acattcccca ggcttttcct gggggccaca gcatgatctt ggattctgaa
      1690       1700       1710       1720       1730       1740
gtgcttctga ttgacaacaa gacaggcaaa ccactgccct ttgggactct gggagtacac
      1750       1760       1770       1780       1790       1800
aagaaagcag ccttccagga tgctaatgtc tgcctgtttg tttttgattg tatctacttt
      1810       1820       1830       1840       1850       1860
aatgatgtca gcttgatgga cagacctctg tgtgagcggc ggaagtttct tcatgacaac
      1870       1880       1890       1900       1910       1920
atggttgaaa ttccaaaccg gatcatgttc tcagaaatga agcgagtcac aaaagctttg
      1930       1940       1950       1960       1970       1980
gacttggctg acatgataac ccgggtgatc caggagggat tggaggggct ggtgctgaag
      1990       2000       2010       2020       2030       2040
gatgtgaagg gtacatatga gcctgggaag cggcactggc tgaaagtgaa gaaagactat
      2050       2060       2070       2080       2090       2100
ttgaacgagg gggccatggc cgacacagct gacctggtgg tccttggagc cttctatggg
      2110       2120       2130       2140       2150       2160
caagggagca aaggcggcat gatgtcaatc ttcctcatgg gctgctacga ccctggcagc
      2170       2180       2190       2200       2210       2220
cagaagtggt gcacagtcac caagtgtgca ggaggccatg atgatgccac gcttgcccgc
      2230       2240       2250       2260       2270       2280
ctgcagaatg aactagacat ggtgaagatc agcaaggacc ccagcaaaat acccagctgg
      2290       2300       2310       2320       2330       2340
ttgaaggtca acaagatcta ctatcctgac ttcatcgtcc cagacccaaa gaaagctgcc
      2350       2360       2370       2380       2390       2400
gtgtgggaga tcacaggggc tgaattctcc aaatcggagg ctcatacagc tgacgggatc
      2410       2420       2430       2440       2450       2460
tccatccgat tccctcgctg cacccgaatc cgagatgata aggactggaa atctgccact
      2470       2480       2490       2500       2510       2520
aaccttcccc aactcaagga actgtaccag ttgtccaagg agaaggcaga cttcactgta
      2530       2540       2550       2560       2570       2580
gtggctggag atgaggggag ctccactaca gggggtagca gtgaagagaa taagggtccc
      2590       2600       2610       2620       2630       2640
tcagggtctg ctgtgtcccg caaggccccc agcaagccct cagccagtac caagaaagca
      2650       2660       2670       2680       2690       2700
gaagggaagc tgagtaactc caacagcaaa gatggcaaca tgcagactgc aaagccttcc
      2710       2720       2730       2740       2750       2760
gctatgaagg tgggggagaa gctggccaca aagtcttctc cagtgaaagt aggggagaag
      2770       2780       2790       2800       2810       2820
cggaaagctg ctgatgagac gctgtgccaa acaaagaggc ggccagccag tgagcagaga
      2830       2840       2850
ggaagaactg tgccagcagg caggagatag   

Last modification date: Oct. 2, 2011