Homo sapiens L. (human) [HSA]

FULL NAME: DNA repair protein XRCC1


DESCRIPTION:
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, DNA polymerase beta (Pol beta) and poly (ADP-ribose) polymerase (PARP) to participate in the base excision repair (BER) pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. XRCC1 corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.

STRUCTURE SIMILARITY:
Contains 2 BRCT domains.


SUBUNIT STRUCTURE:
Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Sumoylated.


RELATED PATHWAY(S):
base excision repair (BER)


Amino acids sequence

        10         20         30         40         50         60
MPEIRLRHVV SCSSQDSTHC AENLLKADTY RKWRAAKAGE KTISVVLQLE KEEQIHSVDI
        70         80         90        100        110        120
GNDGSAFVEV LVGSSAGGAG EQDYEVLLVT SSFMSPSESR SGSNPNRVRM FGPDKLVRAA
       130        140        150        160        170        180
AEKRWDRVKI VCSQPYSKDS PFGLSFVRFH SPPDKDEAEA PSQKVTVTKL GQFRVKEEDE
       190        200        210        220        230        240
SANSLRPGAL FFSRINKTSP VTASDPAGPS YAAATLQASS AASSASPVSR AIGSTSKPQE
       250        260        270        280        290        300
SPKGKRKLDL NQEEKKTPSK PPAQLSPSVP KRPKLPAPTR TPATAPVPAR AQGAVTGKPR
       310        320        330        340        350        360
GEGTEPRRPR AGPEELGKIL QGVVVVLSGF QNPFRSELRD KALELGAKYR PDWTRDSTHL
       370        380        390        400        410        420
ICAFANTPKY SQVLGLGGRI VRKEWVLDCH RMRRRLPSQR YLMAGPGSSS EEDEASHSGG
       430        440        450        460        470        480
SGDEAPKLPQ KQPQTKTKPT QAAGPSSPQK PPTPEETKAA SPVLQEDIDI EGVQSEGQDN
       490        500        510        520        530        540
GAEDSGDTED ELRRVAEQKE HRLPPGQEEN GEDPYAGSTD ENTDSEEHQE PPDLPVPELP
       550        560        570        580        590        600
DFFQGKHFFL YGEFPGDERR KLIRYVTAFN GELEDYMSDR VQFVITAQEW DPSFEEALMD
       610        620        630
NPSLAFVRPR WIYSCNEKQK LLPHQLYGVV PQA  

Encoded by XRCC1 gene

FULL NAME: X-ray repair complementing defective repair in Chinese hamster cells 1


OTHER NAME(S):
RCC


DESCRIPTION:
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgccggaga tccgcctccg ccatgtcgtg tcctgcagca gccaggactc gactcactgt
        70         80         90        100        110        120
gcagaaaatc ttctcaaggc agacacttac cgaaaatggc gggcagccaa ggcaggcgag
       130        140        150        160        170        180
aagaccatct ctgtggtcct acagttggag aaggaggagc agatacacag tgtggacatt
       190        200        210        220        230        240
gggaatgatg gctcagcttt cgtggaggtg ctggtgggca gttcagctgg aggcgctggg
       250        260        270        280        290        300
gagcaagact atgaggtcct tctggtcacc tcatctttca tgtccccttc cgagagccgc
       310        320        330        340        350        360
agtggctcaa accccaaccg cgttcgcatg tttgggcctg acaagctggt ccgggcagcc
       370        380        390        400        410        420
gccgagaagc gctgggaccg ggtcaaaatt gtttgcagcc agccctacag caaggactcc
       430        440        450        460        470        480
ccctttggct tgagttttgt acggtttcat agccccccag acaaagatga ggcagaggcc
       490        500        510        520        530        540
ccgtcccaga aggtgacagt gaccaagctt ggccagttcc gtgtgaagga ggaggatgag
       550        560        570        580        590        600
agcgccaact ctctgaggcc gggggctctc ttcttcagcc ggatcaacaa gacatcccca
       610        620        630        640        650        660
gtcacagcca gcgacccagc aggacctagc tatgcagctg ctaccctcca ggcttctagt
       670        680        690        700        710        720
gctgcctcct cagcctctcc agtctccagg gccataggca gcacctccaa gccccaggag
       730        740        750        760        770        780
tctcccaaag ggaagaggaa gttggatttg aaccaagaag aaaagaagac ccccagcaaa
       790        800        810        820        830        840
ccaccagccc agctgtcgcc atctgttccc aagagaccta aattgccagc tccaactcgt
       850        860        870        880        890        900
accccagcca cagccccagt ccctgcccga gcacaggggg cagtgacagg caaaccccga
       910        920        930        940        950        960
ggagaaggca ccgagcccag acgaccccga gctggcccag aggagctggg gaagatcctt
       970        980        990       1000       1010       1020
cagggtgtgg tagtggtgct gagtggcttc cagaacccct tccgctccga gctgcgagat
      1030       1040       1050       1060       1070       1080
aaggccctag agcttggggc caagtatcgg ccagactgga cccgggacag cacgcacctc
      1090       1100       1110       1120       1130       1140
atctgtgcct ttgccaacac ccccaagtac agccaggtcc taggcctggg aggccgcatc
      1150       1160       1170       1180       1190       1200
gtgcgtaagg agtgggtgct ggactgtcac cgcatgcgtc ggcggctgcc ctcccagagg
      1210       1220       1230       1240       1250       1260
tacctcatgg cagggccagg ttccagcagt gaggaggatg aggcctctca cagcggtggc
      1270       1280       1290       1300       1310       1320
agcggagatg aagcccccaa gcttcctcag aagcaacccc agaccaaaac caagcccact
      1330       1340       1350       1360       1370       1380
caggcagctg gacccagctc accccagaag cccccaaccc ctgaagagac caaagcagcc
      1390       1400       1410       1420       1430       1440
tcaccagtgc tccaggaaga tatagacatt gagggggtac agtcagaagg acaggacaat
      1450       1460       1470       1480       1490       1500
ggggcggaag attctgggga cacagaggat gagctgagga gggtggcaga gcagaaggaa
      1510       1520       1530       1540       1550       1560
cacagactgc cccctggcca ggaggagaat ggggaagacc cgtatgcagg ctccacggat
      1570       1580       1590       1600       1610       1620
gagaacacgg acagtgagga acaccaggag cctcctgatc tgccagtccc tgagctccca
      1630       1640       1650       1660       1670       1680
gatttcttcc agggcaagca cttctttctt tacggggagt tccctgggga cgagcggcgg
      1690       1700       1710       1720       1730       1740
aaactcatcc gatacgtcac agccttcaat ggggagctcg aggactatat gagtgaccgg
      1750       1760       1770       1780       1790       1800
gttcagtttg tgatcacagc acaggaatgg gatcccagct ttgaggaggc cctgatggac
      1810       1820       1830       1840       1850       1860
aacccctccc tggcattcgt tcgtccccga tggatctaca gttgcaatga gaagcagaag
      1870       1880       1890       1900
ttacttcctc accagctcta tggggtggtg ccgcaagcct ga 

Last modification date: Oct. 6, 2011