Homo sapiens L. (human) [HSA]

FULL NAME: High mobility group protein B1


DESCRIPTION:
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).

STRUCTURE SIMILARITY:
Belongs to the HMGB family.
Contains 2 HMG box DNA-binding domains.


PROTEIN TYPE(S):
DNase
dRP-lyase


RELATED PATHWAY(S):
base excision repair (BER)


RELATED DAMAGE:
5'-dRP termini


Amino acids sequence

        10         20         30         40         50         60
MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF
        70         80         90        100        110        120
EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL
       130        140        150        160        170        180
SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK
       190        200        210
SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE  

Encoded by HMGB1 gene

FULL NAME: high mobility group box 1


OTHER NAME(S):
DKFZp686A04236
HMG1
HMG3
SBP-1


Nucleic acid sequence

        10         20         30         40         50         60
atgggcaaag gagatcctaa gaagccgaga ggcaaaatgt catcatatgc attttttgtg
        70         80         90        100        110        120
caaacttgtc gggaggagca taagaagaag cacccagatg cttcagtcaa cttctcagag
       130        140        150        160        170        180
ttttctaaga agtgctcaga gaggtggaag accatgtctg ctaaagagaa aggaaaattt
       190        200        210        220        230        240
gaagatatgg caaaagcgga caaggcccgt tatgaaagag aaatgaaaac ctatatccct
       250        260        270        280        290        300
cccaaagggg agacaaaaaa gaagttcaag gatcccaatg cacccaagag gcctccttcg
       310        320        330        340        350        360
gccttcttcc tcttctgctc tgagtatcgc ccaaaaatca aaggagaaca tcctggcctg
       370        380        390        400        410        420
tccattggtg atgttgcgaa gaaactggga gagatgtgga ataacactgc tgcagatgac
       430        440        450        460        470        480
aagcagcctt atgaaaagaa ggctgcgaag ctgaaggaaa aatacgaaaa ggatattgct
       490        500        510        520        530        540
gcatatcgag ctaaaggaaa gcctgatgca gcaaaaaagg gagttgtcaa ggctgaaaaa
       550        560        570        580        590        600
agcaagaaaa agaaggaaga ggaggaagat gaggaagatg aagaggatga ggaggaggag
       610        620        630        640
gaagatgaag aagatgaaga tgaagaagaa gatgatgatg atgaataa 

Last modification date: Oct. 10, 2011