Homo sapiens L. (human) [HSA]


PROTEIN TYPE(S):
X-family DNA polymerase
dRP-lyase


RELATED PATHWAY(S):
base excision repair (BER)
translesion synthesis (TLS)
non-homologous end-joining (NHEJ)


RELATED DAMAGE:
5'-dRP termini


Amino acids sequence

        10         20         30         40         50         60
MDPRGILKAF PKRQKIHADA SSKVLAKIPR REEGEEAEEW LSSLRAHVVR TGIGRARAEL
        70         80         90        100        110        120
FEKQIVQHGG QLCPAQGPGV THIVVDEGMD YERALRLLRL PQLPPGAQLV KSAWLSLCLQ
       130        140        150        160        170        180
ERRLVDVAGF SIFIPSRYLD HPQPSKAEQD ASIPPGTHEA LLQTALSPPP PPTRPVSPPQ
       190        200        210        220        230        240
KAKEAPNTQA QPISDDEASD GEETQVSAAD LEALISGHYP TSLEGDCEPS PAPAVLDKWV
       250        260        270        280        290        300
CAQPSSQKAT NHNLHITEKL EVLAKAYSVQ GDKWRALGYA KAINALKSFH KPVTSYQEAC
       310        320        330        340        350        360
SIPGIGKRMA EKIIEILESG HLRKLDHISE SVPVLELFSN IWGAGTKTAQ MWYQQGFRSL
       370        380        390        400        410        420
EDIRSQASLT TQQAIGLKHY SDFLERMPRE EATEIEQTVQ KAAQAFNSGL LCVACGSYRR
       430        440        450        460        470        480
GKATCGDVDV LITHPDGRSH RGIFSRLLDS LRQEGFLTDD LVSQEENGQQ QKYLGVCRLP
       490        500        510        520        530        540
GPGRRHRRLD IIVVPYSEFA CALLYFTGSA HFNRSMRALA KTKGMSLSEH ALSTAVVRNT
       550        560        570
HGCKVGPGRV LPTPTEKDVF RLLGLPYREP AERDW  

Encoded by POLL gene

FULL NAME: polymerase (DNA directed), lambda


OTHER NAME(S):
BETAN
FLJ46002
POLKAPPA


DESCRIPTION:
This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3'-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atggatccca ggggtatctt gaaggcattt cccaagcggc agaaaattca tgctgatgca
        70         80         90        100        110        120
tcatcaaaag tacttgcaaa gattcctagg agggaagagg gagaagaagc agaagagtgg
       130        140        150        160        170        180
ctgagctccc ttcgggccca tgttgtgcgc actggcattg gacgagcccg ggcagaactc
       190        200        210        220        230        240
tttgagaagc agattgttca gcatggcggc cagctatgcc ctgcccaggg cccaggtgtc
       250        260        270        280        290        300
actcacattg tggtggatga aggcatggac tatgagcgag ccctccgcct tctcagacta
       310        320        330        340        350        360
ccccagctgc ccccgggtgc tcagctggtg aagtcagcct ggctgagctt gtgccttcag
       370        380        390        400        410        420
gagaggaggc tggtggatgt agctggattc agcatcttca tccccagtag gtacttggac
       430        440        450        460        470        480
catccacagc ccagcaaggc agagcaggat gcttctattc ctcctggcac ccatgaggcc
       490        500        510        520        530        540
ctgcttcaga cagccctttc tcctcctcct cctcccacca ggcctgtgtc tcctccccaa
       550        560        570        580        590        600
aaggcaaaag aggcaccaaa cacccaagcc cagcccatct ctgatgatga agccagtgat
       610        620        630        640        650        660
ggggaagaaa cccaggttag tgcagctgat ctggaagccc tcatcagtgg ccactacccc
       670        680        690        700        710        720
acctcccttg agggagattg tgagcctagc ccagcccctg ctgtcctgga taagtgggtc
       730        740        750        760        770        780
tgtgcacagc cctcaagcca gaaggcgacc aatcacaacc tccatatcac agagaagctg
       790        800        810        820        830        840
gaagttctgg ccaaagccta cagtgttcag ggagacaagt ggagggccct gggctatgcc
       850        860        870        880        890        900
aaggccatca atgccctcaa gagcttccat aagcctgtca cctcgtacca ggaggcctgc
       910        920        930        940        950        960
agtatccctg ggattgggaa gcggatggct gagaaaatca tagagatcct ggagagcggg
       970        980        990       1000       1010       1020
catttgcgga agctggacca tatcagtgag agcgtgcctg tcttggagct cttctccaac
      1030       1040       1050       1060       1070       1080
atctggggag ctgggaccaa gactgcccag atgtggtacc aacagggctt ccgaagtctg
      1090       1100       1110       1120       1130       1140
gaagacatcc gcagccaggc ctccctgaca acccagcagg ccatcggcct gaagcattac
      1150       1160       1170       1180       1190       1200
agtgacttcc tggaacgtat gcccagggag gaggctacag agattgagca gacagtccag
      1210       1220       1230       1240       1250       1260
aaagcagccc aggcctttaa ctctgggctg ctgtgtgtgg catgtggttc ataccgacgg
      1270       1280       1290       1300       1310       1320
ggaaaggcga cctgtggtga tgtcgacgtg ctcatcactc acccagatgg ccggtcccac
      1330       1340       1350       1360       1370       1380
cggggtatct tcagccgcct ccttgacagt cttcggcagg aagggttcct cacagatgac
      1390       1400       1410       1420       1430       1440
ttggtgagcc aagaggagaa tggtcagcaa cagaagtact tgggggtgtg ccggctccca
      1450       1460       1470       1480       1490       1500
gggccagggc ggcggcaccg gcgcctggac atcatcgtgg tgccctatag cgagtttgcc
      1510       1520       1530       1540       1550       1560
tgtgccctgc tctacttcac cggctctgca cacttcaacc gctccatgcg agccctggcc
      1570       1580       1590       1600       1610       1620
aaaaccaagg gcatgagtct gtcagaacat gccctcagca ctgctgtggt ccggaacacc
      1630       1640       1650       1660       1670       1680
catggctgca aggtggggcc tggccgagtg ctgcccactc ccactgagaa ggatgtcttc
      1690       1700       1710       1720
aggctcttag gcctccccta ccgagaacct gctgagcggg actggtga 

Last modification date: Oct. 2, 2011