Homo sapiens L. (human) [HSA]

FULL NAME: DNA-3-methyladenine glycosylase


DESCRIPTION:
Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.

STRUCTURE SIMILARITY:
Belongs to the DNA glycosylase MPG family.


CATALYTIC ACTIVITY:
Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine.


PROTEIN TYPE(S):
DNA N-glycosylase


RELATED PATHWAY(S):
base excision repair (BER)


RELATED DAMAGE:
7-methyl A (7meA)
N7-methyl G (7meG)
1,N6-etheno-A (1εA)
N1-OH-ethyl A (1heA)
1,N2-etheno-G (1,2εG) in dsDNA
N1-methyl A (1meA)
1,N6-ethano A (EA)
1-methyl G (1meG)
8-oxoG from 8-oxoG:C
1,N6-etheno-A in (1εA) dsDNA
3-methyl C (3meC)
3-methyl A (3meA)
N3-methyl G (3meG)


Amino acids sequence

        10         20         30         40         50         60
MPARSGAQFC RRMGQKKQRP ARAGQPHSSS DAAQAPAEQP HSSSDAAQAP CPRERCLGPP
        70         80         90        100        110        120
TTPGPYRSIY FSSPKGHLTR LGLEFFDQPA VPLARAFLGQ VLVRRLPNGT ELRGRIVETE
       130        140        150        160        170        180
AYLGPEDEAA HSRGGRQTPR NRGMFMKPGT LYVYIIYGMY FCMNISSQGD GACVLLRALE
       190        200        210        220        230        240
PLEGLETMRQ LRSTLRKGTA SRVLKDRELC SGPSKLCQAL AINKSFDQRD LAQDEAVWLE
       250        260        270        280        290
RGPLEPSEPA VVAAARVGVG HAGEWARKPL RFYVRGSPWV SVVDRVAEQD TQA

Encoded by MPG gene

FULL NAME: N-methylpurine-DNA glycosylase


OTHER NAME(S):
AAG
ADPG
APNG
CRA36.1
MDG
Mid1
PIG11
PIG16
anpg


Nucleic acid sequence

        10         20         30         40         50         60
atgcccgcgc gcagcggggc ccagttttgc cgacggatgg ggcaaaagaa gcagcgacca
        70         80         90        100        110        120
gctagagcag ggcagccaca cagctcgtcc gacgcagccc aggcacctgc agagcagcca
       130        140        150        160        170        180
cacagctcgt ccgatgcagc ccaggcacct tgccccaggg agcgctgctt gggaccgccc
       190        200        210        220        230        240
accactccgg gcccataccg cagcatctat ttctcaagcc caaagggcca ccttacccga
       250        260        270        280        290        300
ctggggttgg agttcttcga ccagccggca gtccccctgg cccgggcatt tctgggacag
       310        320        330        340        350        360
gtcctagtcc ggcgacttcc taatggcaca gaactccgag gccgcatcgt ggagaccgag
       370        380        390        400        410        420
gcatacctgg ggccagagga tgaagccgcc cactcaaggg gtggccggca gaccccccgc
       430        440        450        460        470        480
aaccgaggca tgttcatgaa gccggggacc ctgtacgtgt acatcattta cggcatgtac
       490        500        510        520        530        540
ttctgcatga acatctccag ccagggggac ggggcttgcg tcttgctgcg agcactggag
       550        560        570        580        590        600
cccctggaag gtctggagac catgcgtcag cttcgcagca ccctccggaa aggcaccgcc
       610        620        630        640        650        660
agccgtgtcc tcaaggaccg cgagctctgc agtggcccct ccaagctgtg ccaggccctg
       670        680        690        700        710        720
gccatcaaca agagctttga ccagagggac ctggcacagg atgaagctgt atggctggag
       730        740        750        760        770        780
cgtggtcccc tggagcccag tgagccggct gtagtggcag cagcccgggt gggcgtcggc
       790        800        810        820        830        840
catgcagggg agtgggcccg gaaacccctc cgcttctatg tccggggcag cccctgggtc
       850        860        870        880
agtgtggtcg acagagtggc tgagcaggac acacaggcct ga 

Last modification date: Oct. 2, 2011