Homo sapiens L. (human) [HSA]

FULL NAME: A/G-specific adenine DNA glycosylase


DESCRIPTION:
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.

STRUCTURE SIMILARITY:
Contains 1 nudix hydrolase domain.
Belongs to the Nth/MutY family.


PROTEIN TYPE(S):
DNA N-glycosylase


RELATED PATHWAY(S):
base excision repair (BER)


RELATED DISEASE(S):
COLORECTAL CANCER
gastric cancer hereditary diffuse (GCDH)


RELATED DAMAGE:
2-oxoA
A from A:8-oxoG
A from A:G
A from A:C
2-oxoA from 2-oxoA:G
2-hydroxy-A (2-OH-A)


Amino acids sequence

        10         20         30         40         50         60
MTPLVSRLSR LWAIMRKPRA AVGSGHRKQA ASQEGRQKHA KNNSQAKPSA CDGLARQPEE
        70         80         90        100        110        120
VVLQASVSSY HLFRDVAEVT AFRGSLLSWY DQEKRDLPWR RRAEDEMDLD RRAYAVWVSE
       130        140        150        160        170        180
VMLQQTQVAT VINYYTGWMQ KWPTLQDLAS ASLEEVNQLW AGLGYYSRGR RLQEGARKVV
       190        200        210        220        230        240
EELGGHMPRT AETLQQLLPG VGRYTAGAIA SIAFGQATGV VDGNVARVLC RVRAIGADPS
       250        260        270        280        290        300
STLVSQQLWG LAQQLVDPAR PGDFNQAAME LGATVCTPQR PLCSQCPVES LCRARQRVEQ
       310        320        330        340        350        360
EQLLASGSLS GSPDVEECAP NTGQCHLCLP PSEPWDQTLG VVNFPRKASR KPPREESSAT
       370        380        390        400        410        420
CVLEQPGALG AQILLVQRPN SGLLAGLWEF PSVTWEPSEQ LQRKALLQEL QRWAGPLPAT
       430        440        450        460        470        480
HLRHLGEVVH TFSHIKLTYQ VYGLALEGQT PVTTVPPGAR WLTQEEFHTA AVSTAMKKVF
       490        500        510        520        530
RVYQGQQPGT CMGSKRSQVS SPCSRKKPRM GQQVLDNFFR SHISTDAHSL NSAAQ

Encoded by MUTYH gene

FULL NAME: mutY homolog (E. coli)


OTHER NAME(S):
CYP2C
MGC4416
MYH


DESCRIPTION:
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgacaccgc tcgtctcccg cctgagtcgt ctgtgggcca tcatgaggaa gccacgagca
        70         80         90        100        110        120
gccgtgggaa gtggtcacag gaagcaggca gccagccagg aagggaggca gaagcatgct
       130        140        150        160        170        180
aagaacaaca gtcaggccaa gccttctgcc tgtgatggcc tggccaggca gccggaagag
       190        200        210        220        230        240
gtggtattgc aggcctctgt ctcctcatac catctattca gagacgtagc tgaagtcaca
       250        260        270        280        290        300
gccttccgag ggagcctgct aagctggtac gaccaagaga aacgggacct accatggaga
       310        320        330        340        350        360
agacgggcag aagatgagat ggacctggac aggcgggcat atgctgtgtg ggtctcagag
       370        380        390        400        410        420
gtcatgctgc agcagaccca ggttgccact gtgatcaact actataccgg atggatgcag
       430        440        450        460        470        480
aagtggccta cactgcagga cctggccagt gcttccctgg aggaggtgaa tcaactctgg
       490        500        510        520        530        540
gctggcctgg gctactattc tcgtggccgg cggctgcagg agggagctcg gaaggtggta
       550        560        570        580        590        600
gaggagctag ggggccacat gccacgtaca gcagagaccc tgcagcagct cctgcctggc
       610        620        630        640        650        660
gtggggcgct acacagctgg ggccattgcc tctatcgcct ttggccaggc aaccggtgtg
       670        680        690        700        710        720
gtggatggca acgtagcacg ggtgctgtgc cgtgtccgag ccattggtgc tgatcccagc
       730        740        750        760        770        780
agcacccttg tttcccagca gctctggggt ctagcccagc agctggtgga cccagcccgg
       790        800        810        820        830        840
ccaggagatt tcaaccaagc agccatggag ctaggggcca cagtgtgtac cccacagcgc
       850        860        870        880        890        900
ccactgtgca gccagtgccc tgtggagagc ctgtgccggg cacgccagag agtggagcag
       910        920        930        940        950        960
gaacagctct tagcctcagg gagcctgtcg ggcagtcctg acgtggagga gtgtgctccc
       970        980        990       1000       1010       1020
aacactggac agtgccacct gtgcctgcct ccctcggagc cctgggacca gaccctggga
      1030       1040       1050       1060       1070       1080
gtggtcaact tccccagaaa ggccagccgc aagcccccca gggaggagag ctctgccacc
      1090       1100       1110       1120       1130       1140
tgtgttctgg aacagcctgg ggcccttggg gcccaaattc tgctggtgca gaggcccaac
      1150       1160       1170       1180       1190       1200
tcaggtctgc tggcaggact gtgggagttc ccgtccgtga cctgggagcc ctcagagcag
      1210       1220       1230       1240       1250       1260
cttcagcgca aggccctgct gcaggaacta cagcgttggg ctgggcccct cccagccacg
      1270       1280       1290       1300       1310       1320
cacctccggc accttgggga ggttgtccac accttctctc acatcaagct gacatatcaa
      1330       1340       1350       1360       1370       1380
gtatatgggc tggccttgga agggcagacc ccagtgacca ccgtaccacc aggtgctcgc
      1390       1400       1410       1420       1430       1440
tggctgacgc aggaggaatt tcacaccgca gctgtttcca ccgccatgaa aaaggttttc
      1450       1460       1470       1480       1490       1500
cgtgtgtatc agggccaaca gccagggacc tgtatgggtt ccaaaaggtc ccaggtgtcc
      1510       1520       1530       1540       1550       1560
tctccgtgca gtcggaaaaa gccccgcatg ggccagcaag tcctggataa tttctttcgg
      1570       1580       1590       1600
tctcacatct ccactgatgc acacagcctc aacagtgcag cccagtga 

Last modification date: Oct. 2, 2011