Homo sapiens L. (human) [HSA]

FULL NAME: Single-strand selective monofunctional uracil DNA glycosylase


DESCRIPTION:
Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.

PROTEIN TYPE(S):
DNA N-glycosylase


RELATED PATHWAY(S):
base excision repair (BER)


RELATED DAMAGE:
5-OH-meU in ssDNA
dU in ssDNA
deoxyuridine
3,N4-etheno-C (εC) in dsDNA
dU from U:A
dU from U:G
5-hydroxy-U (5-OH-U)
5-hydroxymethyl U (5-OH-me-U)
5-formyl dU (5-foU)
5-OH-meU from 5-OH-meU:G
5-OH-meU from 5-OH-meU:A
5-fluoroU from 5-fluoroU:A
ethenoC from ethenoC:G
5-fluoro-dU


Amino acids sequence

        10         20         30         40         50         60
MPQAFLLGSI HEPAGALMEP QPCPGSLAES FLEEELRLNA ELSQLQFSEP VGIIYNPVEY
        70         80         90        100        110        120
AWEPHRNYVT RYCQGPKEVL FLGMNPGPFG MAQTGVPFGE VSMVRDWLGI VGPVLTPPQE
       130        140        150        160        170        180
HPKRPVLGLE CPQSEVSGAR FWGFFRNLCG QPEVFFHHCF VHNLCPLLFL APSGRNLTPA
       190        200        210        220        230        240
ELPAKQREQL LGICDAALCR QVQLLGVRLV VGVGRLAEQR ARRALAGLMP EVQVEGLLHP
       250        260        270
SPRNPQANKG WEAVAKERLN ELGLLPLLLK   

Encoded by SMUG1 gene

FULL NAME: single-strand-selective monofunctional uracil-DNA glycosylase 1


OTHER NAME(S):
FDG
HMUDG
MGC104370
UNG3


DESCRIPTION:
This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]


Nucleic acid sequence

        10         20         30         40         50         60
atgccccagg ctttcctgct ggggtccatc catgagcctg caggtgccct catggagccc
        70         80         90        100        110        120
cagccctgcc ctggaagctt ggctgagagc ttcctggagg aggagcttcg gctcaatgct
       130        140        150        160        170        180
gagctgagcc agctgcagtt ttcggagcct gtgggcatca tctacaatcc cgtggagtat
       190        200        210        220        230        240
gcatgggagc cacatcgcaa ctacgtgact cgctactgcc agggccccaa ggaagtactc
       250        260        270        280        290        300
ttcctgggca tgaaccctgg accttttggc atggcccaga ctggggtgcc ctttggggaa
       310        320        330        340        350        360
gtaagcatgg tccgggactg gttgggcatt gtggggcctg tgctgacccc tccccaagag
       370        380        390        400        410        420
catcctaaac gaccagtgct gggactggag tgcccacagt cagaagtgag tggtgcccga
       430        440        450        460        470        480
ttctggggct ttttccggaa cctctgtgga cagcctgagg tcttcttcca tcactgtttt
       490        500        510        520        530        540
gtccacaatc tatgccctct gcttttcctg gctcccagcg ggcgcaacct tactcctgct
       550        560        570        580        590        600
gagctgcctg ccaagcagcg agaacagctt cttgggatct gtgatgcagc cctctgccgg
       610        620        630        640        650        660
caggtgcagc tgctgggggt gcggctggtg gtgggagttg ggcgactggc agagcagcgg
       670        680        690        700        710        720
gcacgacggg ctctggcagg cctgatgcca gaggtccagg tggaagggct cctgcatccc
       730        740        750        760        770        780
tctccccgta acccacaggc caacaagggc tgggaggcag tggccaagga aagattgaat
       790        800        810
gagctggggc tgctgccact gctgttgaaa tga  

Last modification date: Oct. 2, 2011