Homo sapiens L. (human) [HSA]

Amino acids sequence

        10         20         30         40         50         60
MPEGPLVRKF HHLVSPFVGQ QVVKTGGSSK KLQPASLQSL WLQDTQVHGK KLFLRFDLDE
        70         80         90        100        110        120
EMGPPGSSPT PEPPQKEVQK EGAADPKQVG EPSGQKTLDG SSRSAELVPQ GEDDSEYLER
       130        140        150        160        170        180
DAPAGDAGRW LRVSFGLFGS VWVNDFSRAK KANKRGDWRD PSPRLVLHFG GGGFLAFYNC
       190        200        210        220        230        240
QLSWSSSPVV TPTCDILSEK FHRGQALEAL GQAQPVCYTL LDQRYFSGLG NIIKNEALYR
       250        260        270        280        290        300
AGIHPLSLGS VLSASRREVL VDHVVEFSTA WLQGKFQGRP QHTQVYQKEQ CPAGHQVMKE
       310        320        330
AFGPEDGLQR LTWWCPQCQP QLSEEPEQCQ FS  

Encoded by NEIL2 gene

FULL NAME: nei endonuclease VIII-like 2 (E. coli)


OTHER NAME(S):
FLJ31644
MGC2832
MGC4505
NEH2
NEI2


DESCRIPTION:
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226])[supplied by OMIM, Mar 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgccagaag ggccgttggt gaggaaattt caccatttgg tctccccctt tgtgggtcag
        70         80         90        100        110        120
caggtggtca agacaggggg cagcagtaag aagctacagc ccgccagcct gcagtctctg
       130        140        150        160        170        180
tggctccagg acacccaggt ccatggaaag aaattattcc ttagatttga tctagatgaa
       190        200        210        220        230        240
gaaatggggc cccctggcag cagcccaaca ccagagcctc cacaaaaaga agtgcagaag
       250        260        270        280        290        300
gaaggggctg cggacccaaa gcaggtcggg gagcccagcg ggcagaagac ccttgatgga
       310        320        330        340        350        360
tcctcacggt ctgcagagct cgtcccccag ggcgaggatg attctgagta tttggagaga
       370        380        390        400        410        420
gacgcccctg caggagatgc tgggaggtgg ctgcgtgtca gctttggttt gtttggcagc
       430        440        450        460        470        480
gtttgggtga acgatttctc cagagccaag aaagccaaca agagggggga ctggagggac
       490        500        510        520        530        540
ccttccccga ggttggtcct gcactttggt ggtggtggct tcctggcatt ttataattgt
       550        560        570        580        590        600
cagttgtctt ggagctcttc cccagtggtc acacccacct gtgacatcct gtctgagaag
       610        620        630        640        650        660
ttccatcgag gacaagcctt agaagctcta ggccaggctc agcctgtctg ctatacactg
       670        680        690        700        710        720
ctggaccaga gatacttctc agggctaggg aacatcatta agaatgaagc cttgtacaga
       730        740        750        760        770        780
gctgggatcc atcccctttc tctcggttca gtcctgagtg cctcgcgtcg ggaggtcctg
       790        800        810        820        830        840
gtggatcacg tggtggagtt cagtacagcc tggctgcagg gcaagttcca aggcagaccg
       850        860        870        880        890        900
cagcacacac aggtctacca gaaagaacag tgccctgctg gccaccaggt catgaaggag
       910        920        930        940        950        960
gcgtttgggc ccgaagatgg gttacagagg ctcacctggt ggtgcccgca gtgccagccc
       970        980        990
cagttgtcag aggagccaga gcagtgccag ttctcctaa  

Last modification date: Oct. 2, 2011