Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA replication licensing factor MCM3 homolog


DESCRIPTION:
Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for DNA replication and cell proliferation. May act as a component of the MCM complex which is the putative replicative helicase of the replication licensing system in eukaryotic cells.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDVPEETRLR HKRDFIQFLD SMYMEEIKAL VHQKRHRLII NISDIHHHFR EVASRILKNP
        70         80         90        100        110        120
NEYMQSFCDA ATEATRAIDP KYLKEGELVL VGFEGYFVSR VVTPRELLSD FIGSMVCVEG
       130        140        150        160        170        180
IVTKCSLVRP KVVKSVHFCP STGEFTNRDY RDITSHAGLP TGSVYPTRDD KGNLLVTEYG
       190        200        210        220        230        240
LCKYKDHQTL SIQEVPENAA PGQLPRSVDV IAEDDLVDSC KPGDRVSVFG IYKALPGKSK
       250        260        270        280        290        300
GSVNGVFRTI LIANNIALLN KEANAPIYTK QDLDNIKNIA RRDDAFDLLA RSLAPSIYGH
       310        320        330        340        350        360
AWIKKAVVLL MLGGVEKNLK NGTHLRGDIN MMMVGDPSVA KSQLLRAIMN IAPLAISTTG
       370        380        390        400        410        420
RGSSGVGLTA AVTSDQETGE RRLEAGAMVL ADKGIVCIDE FDKMNDQDRV AIHEVMEQQT
       430        440        450        460        470        480
VTIAKAGIHA SLNARCSVVA AANPIYGTYD RSLTPTKNIG LPDSLLSRFD LLFIVLDQMD
       490        500        510        520        530        540
AGIDSMISEH VLRMHRYKND RGEAGPDGSL PYAREDNAES EMFVKYNQTL HGKKKRGQTH
       550        560        570        580        590        600
DKTLTIKFLK KYIHYAKHRI TPKLTDEASE RIAEAYADLR NAGSDTKTGG TLPITARTLE
       610        620        630        640        650        660
TIIRLATAHA KMKLSSEVTK ADAEAALKLM NFAIYHQELT EMDDREQEER QREQAEQERT
       670        680        690        700        710        720
PSGRRGNQRR NNEDGAENDT ANVDSETADP MEVDEPSVEQ FSGTVSAARI ETFERVFGQH
       730        740        750        760        770
MRTHRLDDIS IADIETVVNN NGVGASRYSA DEIMALLEKL QDDNKVMISD GKVHII

Encoded by MCM3 gene


OTHER NAME(S):
MINICHROMOSOME MAINTENANCE 3
MPL12.6
MPL12_6


Nucleic acid sequence

        10         20         30         40         50         60
atggatgtgc cagaggagac gaggcttcgc cacaagcgag attttatcca gttcctcgat
        70         80         90        100        110        120
agtatgtata tggaggaaat caaggctttg gtacatcaaa agcgtcaccg tctcattatt
       130        140        150        160        170        180
aatatctctg acattcacca ccacttcagg gaagttgcct ctaggatact gaagaatcca
       190        200        210        220        230        240
aatgagtata tgcagtcatt ttgtgacgca gccactgaag ctactcgtgc tattgaccct
       250        260        270        280        290        300
aaatacttga aggaaggaga gcttgtcctt gttggttttg aaggttattt tgtttctcgc
       310        320        330        340        350        360
gttgttactc ctagagagct tctctctgat tttattggat ctatggtctg tgttgagggc
       370        380        390        400        410        420
attgtcacca aatgctctct tgtgaggcca aaggttgtta aaagcgttca cttttgtcca
       430        440        450        460        470        480
tcaaccggtg aatttaccaa tcgagattat cgagacataa catctcacgc tggtttaccc
       490        500        510        520        530        540
actggctctg tctatcccac aagggatgat aagggaaact tattggtgac tgagtatggg
       550        560        570        580        590        600
ctgtgcaaat acaaagatca ccagaccttg tcaattcaag aagtgcctga aaatgctgct
       610        620        630        640        650        660
cctggtcagc ttccacgaag cgttgatgtc attgctgagg atgaccttgt tgactcatgc
       670        680        690        700        710        720
aagccaggag atcgagtatc tgttttcggt atttacaaag ctcttcctgg aaaaagcaag
       730        740        750        760        770        780
ggtagtgtaa atggagtctt taggactatc ctcatagcca ataatatcgc tctgctcaat
       790        800        810        820        830        840
aaagaagcaa atgcacctat atacactaag caagacctag ataacattaa aaatattgca
       850        860        870        880        890        900
cgaagagatg atgcatttga tctccttgct cgttccttag caccttctat ttatgggcac
       910        920        930        940        950        960
gcttggataa agaaagcagt agttttactg atgcttggtg gtgttgaaaa gaacctgaag
       970        980        990       1000       1010       1020
aacggaaccc acttgagggg agacatcaac atgatgatgg ttggtgatcc atctgttgcc
      1030       1040       1050       1060       1070       1080
aaatctcaac ttctgagagc gataatgaat attgcacctt tggctatatc aaccacaggc
      1090       1100       1110       1120       1130       1140
cgtggttctt ccggtgttgg gttaactgct gctgtgactt ctgaccaaga aacaggggaa
      1150       1160       1170       1180       1190       1200
cgaagactag aagctggtgc aatggtcctc gctgataaag gtatcgtgtg cattgacgag
      1210       1220       1230       1240       1250       1260
tttgataaga tgaatgatca ggaccgagtt gctatacacg aagtgatgga gcaacagact
      1270       1280       1290       1300       1310       1320
gtaacaattg caaaagccgg tatccatgca tcactgaatg ctagatgcag tgtggttgca
      1330       1340       1350       1360       1370       1380
gctgcaaatc ccatatacgg aacttatgac agatcactga ctccaacaaa gaacattgga
      1390       1400       1410       1420       1430       1440
cttccagatt cgctgctttc tcgttttgat ctactgttta ttgtgttgga tcaaatggat
      1450       1460       1470       1480       1490       1500
gctggtatcg acagcatgat ttcagaacat gtcttgcgca tgcatcgtta caagaacgat
      1510       1520       1530       1540       1550       1560
agaggtgagg cagggccaga tgggagcttg ccttacgcga gagaagacaa tgctgagagt
      1570       1580       1590       1600       1610       1620
gaaatgtttg ttaagtataa ccaaacacta catgggaaga agaaaagagg ccaaacacat
      1630       1640       1650       1660       1670       1680
gataaaaccc ttacgattaa gttcttgaag aagtacattc attacgccaa gcaccgtatt
      1690       1700       1710       1720       1730       1740
acaccaaagc tcactgatga agcatcggaa cgtattgcag aagcatatgc agatctcaga
      1750       1760       1770       1780       1790       1800
aatgcaggtt ccgatactaa gactggaggt acgcttccga taacagccag aactctagag
      1810       1820       1830       1840       1850       1860
acaataattc gtcttgctac ggcacatgcc aaaatgaagt tgagtagcga ggttactaaa
      1870       1880       1890       1900       1910       1920
gctgatgcag aggctgcctt gaagcttatg aactttgcaa tatatcatca agaattaact
      1930       1940       1950       1960       1970       1980
gagatggatg atcgtgagca agaagaacgt caaagggaac aagctgaaca agaaagaaca
      1990       2000       2010       2020       2030       2040
ccaagtggac gtagaggcaa ccaacgcagg aataatgaag atggagcaga gaatgacact
      2050       2060       2070       2080       2090       2100
gcaaatgtcg acagtgaaac agcagatcca atggaagtag atgaaccttc tgtagagcaa
      2110       2120       2130       2140       2150       2160
ttcagcggca cggtctctgc agcaaggatt gaaacctttg agcgagtgtt tgggcagcac
      2170       2180       2190       2200       2210       2220
atgaggacac acaggctcga tgacatctct attgcagata tagagactgt tgtcaacaac
      2230       2240       2250       2260       2270       2280
aatggggttg gagcatctcg ttactctgca gatgagatta tggctctctt agagaaactg
      2290       2300       2310       2320       2330
caagatgata acaaagtgat gatcagcgat ggcaaagttc atatcatttg a

Last modification date: Dec. 13, 2011