Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA polymerase delta catalytic subunit


DESCRIPTION:
This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
Catalytic activity	: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


SUBUNIT STRUCTURE:
Heterodimer with subunits of 125 kDa and 50 kDa. The 125 kDa subunit contains the polymerase active site and most likely the active site for the 3'-5' exonuclease activity (By similarity).


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MNRSGISKKR PPPSNTPPPA GKHRATGDST PSPAIGTLDD EFMMEEDVFL DETLLYGDED
        70         80         90        100        110        120
EESLILRDIE ERESRSSAWA RPPLSPAYLS NSQSIIFQQL EIDSIIAESH KELLPGSSGQ
       130        140        150        160        170        180
APIIRMFGVT REGNSVCCFV HGFEPYFYIA CPPGMGPDDI SNFHQSLEGR MRESNKNAKV
       190        200        210        220        230        240
PKFVKRIEMV QKRSIMYYQQ QKSQTFLKIT VALPTMVASC RGILDRGLQI DGLGMKSFQT
       250        260        270        280        290        300
YESNILFVLR FMVDCDIVGG NWIEVPTGKY KKNARTLSYC QLEFHCLYSD LISHAAEGEY
       310        320        330        340        350        360
SKMAPFRVLS FDIECAGRKG HFPEAKHDPV IQIANLVTLQ GEDHPFVRNV MTLKSCAPIV
       370        380        390        400        410        420
GVDVMSFETE REVLLAWRDL IRDVDPDIII GYNICKFDLP YLIERAATLG IEEFPLLGRV
       430        440        450        460        470        480
KNSRVRVRDS TFSSRQQGIR ESKETTIEGR FQFDLIQAIH RDHKLSSYSL NSVSAHFLSE
       490        500        510        520        530        540
QKEDVHHSII TDLQNGNAET RRRLAVYCLK DAYLPQRLLD KLMFIYNYVE MARVTGVPIS
       550        560        570        580        590        600
FLLARGQSIK VLSQLLRKGK QKNLVLPNAK QSGSEQGTYE GATVLEARTG FYEKPIATLD
       610        620        630        640        650        660
FASLYPSIMM AYNLCYCTLV TPEDVRKLNL PPEHVTKTPS GETFVKQTLQ KGILPEILEE
       670        680        690        700        710        720
LLTARKRAKA DLKEAKDPLE KAVLDGRQLA LKISANSVYG FTGATVGQLP CLEISSSVTS
       730        740        750        760        770        780
YGRQMIEQTK KLVEDKFTTL GGYQYNAEVI YGDTDSVMVQ FGVSDVEAAM TLGREAAEHI
       790        800        810        820        830        840
SGTFIKPIKL EFEKVYFPYL LINKKRYAGL LWTNPQQFDK MDTKGIETVR RDNCLLVKNL
       850        860        870        880        890        900
VTESLNKILI DRDVPGAAEN VKKTISDLLM NRIDLSLLVI TKGLTKTGDD YEVKSAHGEL
       910        920        930        940        950        960
AERMRKRDAA TAPNVGDRVP YVIIKAAKGA KAYERSEDPI YVLQNNIPID PNYYLENQIS
       970        980        990       1000       1010       1020
KPLLRIFEPV LKNASKELLH GSHTRSISIT TPSNSGIMKF AKKQLSCVGC KVPISNGTLC
      1030       1040       1050       1060       1070       1080
ASCKGREAEL YCKNVSQVAE LEEVFGRLWT QCQECQGSLH QDVLCTSRDC PIFYRRMKAQ
      1090
KDMAVARQQL DRWSF    

Encoded by EMB2780 gene


OTHER NAME(S):
EMBRYO DEFECTIVE 2780
MBM17.6
MBM17_6


Nucleic acid sequence

        10         20         30         40         50         60
atgaatagat ccggtatttc caaaaagcga ccgcctcctt cgaatacccc accaccggcg
        70         80         90        100        110        120
ggtaagcatc gagccactgg tgattcaaca ccatctccgg ccatcggaac cctagatgat
       130        140        150        160        170        180
gaatttatga tggaagagga cgtgtttctg gacgaaactc tcttgtacgg cgacgaagat
       190        200        210        220        230        240
gaggaatccc taatcctccg tgacattgag gagcgtgaat cgcgttcctc ggcttgggct
       250        260        270        280        290        300
cgacctccgc tctcccccgc gtatctctcg aattcacaga gtatcatttt ccaacaattg
       310        320        330        340        350        360
gagattgact ctataatcgc ggagagtcat aaggagctgt taccgggttc ctcagggcaa
       370        380        390        400        410        420
gctccaatca ttaggatgtt tggggttacc agagaaggta acagtgtgtg ttgctttgtt
       430        440        450        460        470        480
catggatttg agccatactt ttacattgct tgccctcctg gaatggggcc agacgatatt
       490        500        510        520        530        540
tctaatttcc atcagagtct tgagggaagg atgagggaat ccaataaaaa tgccaaggtc
       550        560        570        580        590        600
ccgaaatttg ttaaacgtat agaaatggtg cagaaaagaa gcattatgta ttaccaacag
       610        620        630        640        650        660
caaaaatccc aaacttttct gaagattaca gttgcattgc cgactatggt ggcaagctgt
       670        680        690        700        710        720
cgcggcatcc ttgatagagg cctacaaatt gatggattgg gtatgaagag cttccagaca
       730        740        750        760        770        780
tatgaaagca atattctttt cgttctccgt ttcatggttg attgtgatat tgtcggagga
       790        800        810        820        830        840
aattggattg aagtacctac tgggaagtat aagaaaaatg caagaacttt gtcatactgc
       850        860        870        880        890        900
caattggagt tccattgcct gtactcagat ctaatcagtc atgctgcaga aggtgaatac
       910        920        930        940        950        960
tcaaaaatgg ctccattccg tgtactaagt ttcgatattg agtgtgcagg tcgtaaagga
       970        980        990       1000       1010       1020
cattttccgg aagctaagca tgatcctgta atccagatag cgaaccttgt tactcttcag
      1030       1040       1050       1060       1070       1080
ggagaggatc acccatttgt acgcaatgtc atgactctta agtcatgtgc tccaatcgta
      1090       1100       1110       1120       1130       1140
ggcgtagatg tcatgtcttt tgaaacagaa agagaggtct tactagcttg gagggatttg
      1150       1160       1170       1180       1190       1200
attcgtgatg ttgatcctga tatcatcatt ggttataaca tctgcaaatt cgatttacct
      1210       1220       1230       1240       1250       1260
tatctgattg agagagctgc tacactggga atagaggaat ttcctcttct tggtcgtgta
      1270       1280       1290       1300       1310       1320
aagaacagta gggtccgggt cagggactca acattttcat caagacaaca aggaataaga
      1330       1340       1350       1360       1370       1380
gaaagtaaag agaccacaat tgaaggaaga tttcagtttg accttattca ggcaatacac
      1390       1400       1410       1420       1430       1440
agagaccaca aattaagttc ttattcgctg aattctgtct cagctcactt tctttccgag
      1450       1460       1470       1480       1490       1500
cagaaagaag atgtccacca ttctataata actgatctcc agaatgggaa tgcggaaacc
      1510       1520       1530       1540       1550       1560
aggaggcgtc ttgctgttta ttgtttgaag gatgcatatc ttcctcagag gcttctggac
      1570       1580       1590       1600       1610       1620
aaactgatgt ttatatataa ttatgtcgaa atggctcgtg taactggtgt ccctatttca
      1630       1640       1650       1660       1670       1680
tttcttcttg cgagaggaca gagtatcaag gttttatctc agcttcttag gaaaggcaaa
      1690       1700       1710       1720       1730       1740
cagaaaaatc tggttcttcc aaatgctaaa cagtcagggt ccgaacaagg aacttatgaa
      1750       1760       1770       1780       1790       1800
ggcgcaactg ttttagaagc aagaacaggt ttctatgaaa agccaattgc aactttggat
      1810       1820       1830       1840       1850       1860
tttgcttcac tgtacccgtc aattatgatg gcatataatc tgtgctactg caccttggtg
      1870       1880       1890       1900       1910       1920
acacctgaag atgtacgcaa actgaatctt ccacctgaac atgtcactaa aactccatca
      1930       1940       1950       1960       1970       1980
ggggaaacat ttgttaagca aactttgcaa aagggtatac ttccagaaat tctcgaagag
      1990       2000       2010       2020       2030       2040
cttcttactg cccgtaagag agctaaagca gatttaaagg aggctaagga tccccttgag
      2050       2060       2070       2080       2090       2100
aaggctgttt tagatggtag acagttagcg ttgaagatca gtgcaaattc tgtctacggg
      2110       2120       2130       2140       2150       2160
tttacgggag ccactgttgg gcagttacca tgcttagaaa tatcctcgag tgtaactagc
      2170       2180       2190       2200       2210       2220
tatggtcgtc agatgattga acaaacaaag aaacttgttg aagacaaatt cacaacactg
      2230       2240       2250       2260       2270       2280
ggagggtatc aatacaatgc agaggtcatt tatggagaca cggattcagt catggtgcaa
      2290       2300       2310       2320       2330       2340
tttggagtat cggatgtaga agctgcgatg accttgggga gggaagctgc agaacacatt
      2350       2360       2370       2380       2390       2400
agtggaactt ttatcaaacc catcaaattg gagtttgaaa aggtctattt cccatatctt
      2410       2420       2430       2440       2450       2460
ctcattaaca agaagaggta tgctggtttg ctatggacaa atcctcaaca gtttgacaaa
      2470       2480       2490       2500       2510       2520
atggacacca aaggaatcga gacagtacga agggataatt gtttactggt taagaacctc
      2530       2540       2550       2560       2570       2580
gtgactgaga gtcttaacaa aatacttatt gatagagatg ttccaggggc agctgaaaat
      2590       2600       2610       2620       2630       2640
gtcaagaaaa ccatttcgga tcttctcatg aaccgtattg acttgtcact tttggtgatt
      2650       2660       2670       2680       2690       2700
actaagggtc taacgaaaac aggagatgat tatgaagtta aatcagctca tggtgaactt
      2710       2720       2730       2740       2750       2760
gctgaacgca tgcgtaagag ggatgctgct acagcgccaa atgttggaga tcgagtaccg
      2770       2780       2790       2800       2810       2820
tatgttatca taaaagctgc taaaggtgcc aaggcttatg aacgatcaga agatccaatc
      2830       2840       2850       2860       2870       2880
tacgtgctac agaataatat ccctatagac ccaaattact acttggagaa tcagattagc
      2890       2900       2910       2920       2930       2940
aagccacttc ttaggatttt tgagccagtc ctgaaaaatg ctagcaagga gcttctccat
      2950       2960       2970       2980       2990       3000
ggaagtcaca cgaggtcaat atcaatcact actccttcaa acagcggtat aatgaagttt
      3010       3020       3030       3040       3050       3060
gctaaaaaac aactgagctg tgttggctgc aaagttccga tcagcaatgg aacactatgc
      3070       3080       3090       3100       3110       3120
gcaagttgca agggaagaga agccgagtta tattgcaaaa acgtgtctca agtggctgag
      3130       3140       3150       3160       3170       3180
cttgaagagg tttttgggag gctgtggaca cagtgccagg agtgtcaagg ctctcttcat
      3190       3200       3210       3220       3230       3240
caagatgtct tgtgcaccag tcgagattgt ccaatatttt accggagaat gaaagcacaa
      3250       3260       3270       3280
aaagacatgg ctgtagccag gcaacaactc gaccgttgga gcttctaa 

Last modification date: Dec. 13, 2011