Homo sapiens L. (human) [HSA]

FULL NAME: N-glycosylase/DNA lyase


DESCRIPTION:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.
OGG1 is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct that occurs as a result of exposure to reactive oxygen species (ROS). OGG1 is a bifunctional glycosylase, as it is able to both cleave the glycosidic bond of the mutagenic lesion and cause a strand break in the DNA backbone. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants have the N-terminal region in common. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. The N-terminus of this gene contains a mitochondrial targeting signal, essential for mitochondrial localization.

STRUCTURE SIMILARITY:
Belongs to the type-1 OGG1 family.


CATALYTIC ACTIVITY:
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.


PROTEIN TYPE(S):
DNA N-glycosylase/AP-lyase
DNase
endonuclease
AP-lyase


RELATED PATHWAY(S):
base excision repair (BER)


RELATED DISEASE(S):
renal cell carcinoma (RCC)


RELATED DAMAGE:
8-oxoG
Fapy-7meG
8-oxoA
8-oxoG from 8-oxoG:C
8-oxoG from 8-oxoG:A
8-oxoG from 8-oxoG:G
8-oxoG from 8-oxoG:T
FapyG from FapyG:C
Fapy-7meG from Fapy-7meG:C
FapyG
8-hydroxyA (8-OH-A)


Amino acids sequence

        10         20         30         40         50         60
MPARALLPRR MGHRTLASTP ALWASIPCPR SELRLDLVLP SGQSFRWREQ SPAHWSGVLA
        70         80         90        100        110        120
DQVWTLTQTE EQLHCTVYRG DKSQASRPTP DELEAVRKYF QLDVTLAQLY HHWGSVDSHF
       130        140        150        160        170        180
QEVAQKFQGV RLLRQDPIEC LFSFICSSNN NIARITGMVE RLCQAFGPRL IQLDDVTYHG
       190        200        210        220        230        240
FPSLQALAGP EVEAHLRKLG LGYRARYVSA SARAILEEQG GLAWLQQLRE SSYEEAHKAL
       250        260        270        280        290        300
CILPGVGTKV ADCICLMALD KPQAVPVDVH MWHIAQRDYS WHPTTSQAKG PSPQTNKELG
       310        320        330        340
NFFRSLWGPY AGWAQAVLFS ADLRQSRHAQ EPPAKRRKGS KGPEG 

Encoded by OGG1 gene

FULL NAME: 8-oxoguanine DNA glycosylase


OTHER NAME(S):
HMMH
HOGG1
MUTM
OGH1


DESCRIPTION:
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgcctgccc gcgcgcttct gcccaggcgc atggggcatc gtactctagc ctccactcct
        70         80         90        100        110        120
gccctgtggg cctccatccc gtgccctcgc tctgagctgc gcctggacct ggttctgcct
       130        140        150        160        170        180
tctggacaat ctttccggtg gagggagcaa agtcctgcac actggagtgg tgtactagcg
       190        200        210        220        230        240
gatcaagtat ggacactgac tcagactgag gagcagctcc actgcactgt gtaccgagga
       250        260        270        280        290        300
gacaagagcc aggctagcag gcccacacca gacgagctgg aggccgtgcg caagtacttc
       310        320        330        340        350        360
cagctagatg ttaccctggc tcaactgtat caccactggg gttccgtgga ctcccacttc
       370        380        390        400        410        420
caagaggtgg ctcagaaatt ccaaggtgtg cgactgctgc gacaagaccc catcgaatgc
       430        440        450        460        470        480
cttttctctt ttatctgttc ctccaacaac aacatcgccc gcatcactgg catggtggag
       490        500        510        520        530        540
cggctgtgcc aggcttttgg acctcggctc atccagcttg atgatgtcac ctaccatggc
       550        560        570        580        590        600
ttccccagcc tgcaggccct ggctgggcca gaggtggagg ctcatctcag gaagctgggc
       610        620        630        640        650        660
ctgggctatc gtgcccgtta cgtgagtgcc agtgcccgag ccatcctgga agaacagggc
       670        680        690        700        710        720
gggctagcct ggctgcagca gctacgagag tcctcatatg aggaggccca caaggccctc
       730        740        750        760        770        780
tgcatcctgc ctggagtggg caccaaggtg gctgactgca tctgcctgat ggccctagac
       790        800        810        820        830        840
aagccccagg ctgtgcccgt ggatgtccat atgtggcaca ttgcccaacg tgactacagc
       850        860        870        880        890        900
tggcacccta ccacgtccca ggcgaaggga ccgagccccc agaccaacaa ggaactggga
       910        920        930        940        950        960
aactttttcc ggagcctgtg gggaccttat gctggctggg cccaagcggt gctgttcagt
       970        980        990       1000       1010       1020
gccgacctgc gccaatcccg ccatgctcag gagccaccag caaagcgcag aaagggttcc
      1030
aaagggccgg aaggctag    

Last modification date: Oct. 9, 2011