Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA polymerase


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSGRRCDRRL NVQKVSAADE LETKLGFGLF SQGETRLGWL LTFASSSWED ADTGKTFSCV
        70         80         90        100        110        120
DLFFVTQDGS SFKTKYKFRP YLYAATKDNM ELEVEAYLRR RYERQVADIQ IVHKEDLYLK
       130        140        150        160        170        180
NHLSGLQKKY LKVSFDTVQQ LVEVKRDLLH IVERNLAKFN ALEAYESILS GKREQRPQDC
       190        200        210        220        230        240
LDSVVDLREY DVPYHVRFAI DNDVRSGQWY NVSISSTDVI LEKRTDLLQR AEVRVCAFDI
       250        260        270        280        290        300
ETVKLPLKFP DAEYDQIMMI SYMVDGQGFL ITNRECVGKD IEDLEYTPKP EFEGYFKVTN
       310        320        330        340        350        360
VTNEVELLRK WFSHMQELKP GIYVTYNGDF FDWPFIERRA SHHGIKMNEE LGFRCDQNQG
       370        380        390        400        410        420
ECRAKFVCHL DCFSWVKRDS YLPQGSQGLK AVTKVKLGYD PLEVNPEDMV RFAMEKPQTM
       430        440        450        460        470        480
ASYSVSDAVA TYYLYMTYVH PFVFSLATII PMVPDEVLRK GSGTLCEMLL MVEAYKANVV
       490        500        510        520        530        540
CPNKNQADPE KFYQGKLLES ETYIGGHVEC LQSGVFRSDI PTSFKLDASA YQQLIDNLGR
       550        560        570        580        590        600
DLEYAITVEG KMRMDSVSNF DEVKEVIREK LEKLRDDPIR EEGPLIYHLD VAAMYPNIIL
       610        620        630        640        650        660
TNRLQPPSIV TDEVCTACDF NGPEKTCLRK LEWVWRGVTF KGNKSEYYHL KKQIESESVD
       670        680        690        700        710        720
AGANMQSSKP FLDLPKVEQQ SKLKERLKKY CQKAYSRVLD KPITEVREAG ICMRENPFYV
       730        740        750        760        770        780
DTVRSFRDRR YEYKTLNKVW KGKLSEAKAS GNLIKIQEAH DMVVVYDSLQ LAHKCILNSF
       790        800        810        820        830        840
YGYVMRKGAR WYSMEMAGVV TYTGAKIIQN ARLLIERIGK PLELDTDGIW CALPGSFPEN
       850        860        870        880        890        900
FTFKTIDMKK FTISYPCVIL NVDVAKNNSN DQYQTLVDPV RKTYNSRSEC SIEFEVDGPY
       910        920        930        940        950        960
KAMIIPASKE EGILIKKRYA VFNHDGTIAE LKGFEMKRRG ELKLIKVFQA ELFDKFLHGS
       970        980        990       1000       1010       1020
TLEECYSAVA AVANRWLDLL EGQGKDIADS ELLDYISESS TMSKSLADYG QQKSCAVTTA
      1030       1040       1050       1060       1070       1080
KRLADFLGDT MVKDKGLRCQ YIVAREPEGT PVSERAVPVA IFQTDDPEKK FYLQKWCKIS
      1090       1100       1110       1120       1130       1140
SYTGIRSIID WMYYKQRLHS AIQKVITIPA AMQKVANPVL RVRHPYWLEK KVCDKFRQGK
      1150       1160       1170       1180       1190       1200
IVDMFSSANK DHSTTQDNVV ADIEEFCKEN RPSVKGPKPV ARSFEVDRNH SEGKQQESWD
      1210       1220       1230       1240       1250       1260
PEFHDISLQN VDKNVDYQGW LELEKRKWKM TLTNKKKRRY SSSLFGFDLE QNINKKVCKG
      1270       1280       1290       1300       1310       1320
RVGVGSYFRR PEEALTSSYL QIIQLVQSPQ SGQFFAWVVV EGLMLKIPLT IPRVFYINSK
      1330       1340       1350       1360       1370       1380
ASIAGNFTGK CINKILPHGK PCYNLMEVNI QEDQFIKESK KLAALLADPE IEGIYETKMP
      1390       1400       1410       1420       1430       1440
LEFSAICQIG CVCKIEDTAK HRNTQDGWKL GELHRITTTE CRYLENSIPL VYLYHSTSTG
      1450       1460       1470       1480       1490       1500
RAVYVLYCHA SKLMSVVVVN PYGDKELLSS ALERQFRDRC QELSPEPFSW DGILFQVEYV
      1510       1520       1530       1540       1550       1560
DHPEAATKFL QKALCEYREE NCGATVAVIE CPDFNTTKEG VKALEDFPCV RIPFNDDDNS
      1570       1580       1590       1600       1610       1620
YQPVSWQRPA AKIAVLRCAS AIQWLDRRIA QSRYAHVPLG NFGRDWLTFT VDIFLSRALR
      1630       1640       1650       1660       1670       1680
DQQQVLWVSD NGVPDLGDIN NEETFLADET SLLFPGAYRK VSVELKVHRL AVNALLKSDL
      1690       1700       1710       1720       1730       1740
VSEMEGGGFL GVNSRGSSLN DNGSFDENNG CAQAFRVLKQ LIKRLLHDAC NSGNIYADSI
      1750       1760       1770       1780       1790       1800
LQHLSWWLRS PSSKLHDPAL HLMLHKVMQK VFALLLTDLR RLGAIIIYAD FSKVIIDTGK
      1810       1820       1830       1840       1850       1860
FDLSAAKTYC ESLLTVMGSR DIFKLILLEP VHYWHSLLFM DQHNYAGIRA TGDEISGNEV
      1870       1880       1890       1900       1910       1920
TIEPKWSVAR HLPEYIQKDF IIIVATFIFG PWKFALEKKR GSAESLEAEM VEYLKEQIGT
      1930       1940       1950       1960       1970       1980
RFISMIVEKI GNIRSHIKDI NVSDASWASG QAPKGDYTFE FIQIITAVLA LDQNVQQDVL
      1990       2000       2010       2020       2030       2040
VMRKILLKYI KVKECAAEAE FIDPGPSFIL PNVACSNCGA YRDLDFCRDS ALLTEKEWSC
      2050       2060       2070       2080       2090       2100
ADPQCVKIYD KEQIESSIIQ MVRQRERMYQ LQDLVCNRCN QVKAAHLTEQ CECSGSFRCK
      2110       2120       2130
ESGSDFHKRI EIFLDIAKRQ KFRLLEECIS WILFATSC  

Encoded by TIL2 gene


OTHER NAME(S):
POL2B
T20P8.17
T20P8_17
TIL2
TILTED 2


DESCRIPTION:
Encodes a protein with similarity to DNA polymerase epsilon catalytic subunit. Based on yeast two hybrid analysis, not predicted to be a subunit of the DNA polymerase epsilon complex. No phenotype observed in homozygous mutant embryos or plants but in combination with TIL1-1/til1-1 heterozygotes arrest earlier than til1 homozygotes suggesting TIL2 functions redundantly with TIL1.


Nucleic acid sequence

        10         20         30         40         50         60
atgagcggaa ggagatgtga tcggaggttg aatgtgcaga aagtttcagc ggcagatgaa
        70         80         90        100        110        120
ctcgaaacta aacttggatt tgggcttttc tcccaagggg aaacgcggct cgggtggcta
       130        140        150        160        170        180
ctcacgtttg catcatcatc ttgggaagat gccgatactg ggaaaacctt tagttgtgtg
       190        200        210        220        230        240
gaccttttct ttgtcactca ggacggctct tcttttaaga ctaagtacaa gttccgccct
       250        260        270        280        290        300
tacttgtatg ccgccaccaa agacaatatg gaactggaag ttgaagccta cttgagacgc
       310        320        330        340        350        360
cgatatgaaa gacaagttgc tgatattcag attgttcaca aagaagatct ttatcttaaa
       370        380        390        400        410        420
aatcatctat ctggcctgca aaaaaaatat ctcaaagtat catttgacac tgtgcaacaa
       430        440        450        460        470        480
ttggtggaag taaagaggga tctgttgcat attgtcgaac gaaacctcgc aaaatttaat
       490        500        510        520        530        540
gcacttgaag cttacgaatc catcttgtct ggaaaacgag aacaacgtcc tcaagactgc
       550        560        570        580        590        600
ttagactctg tggtggacct ccgcgagtac gatgttcctt atcatgtccg atttgcaatt
       610        620        630        640        650        660
gataatgatg tgcgtagtgg gcaatggtac aatgtcagta tttccagcac tgatgtcata
       670        680        690        700        710        720
ctagagaaga ggacggatct tctccaacgc gcagaagttc gcgtttgtgc attcgatata
       730        740        750        760        770        780
gagacagtaa agcttccatt gaagttcccg gatgctgaat atgatcaaat tatgatgata
       790        800        810        820        830        840
tcctacatgg ttgatgggca aggttttcta attactaaca gagagtgtgt tggcaaagac
       850        860        870        880        890        900
atagaagatc tggaatatac acccaaacca gagtttgaag ggtatttcaa agtcacgaat
       910        920        930        940        950        960
gttaccaacg aggttgaact cctccgaaaa tggttttctc atatgcaaga gttgaaacct
       970        980        990       1000       1010       1020
ggtatttatg ttacatacaa cggtgacttt tttgactggc catttataga acggagagca
      1030       1040       1050       1060       1070       1080
tctcatcatg ggatcaaaat gaacgaggag ttgggattcc gttgtgatca aaatcaaggt
      1090       1100       1110       1120       1130       1140
gaatgtcgag ctaagtttgt gtgccatttg gattgttttt cttgggtgaa acgtgatagc
      1150       1160       1170       1180       1190       1200
tatcttcctc agggaagcca gggtctgaag gctgttacaa aggtaaaact gggttacgat
      1210       1220       1230       1240       1250       1260
ccactggaag tgaatcctga ggacatggtt cggtttgcaa tggaaaagcc acagacaatg
      1270       1280       1290       1300       1310       1320
gcctcctact ctgtctctga tgctgttgca acttactacc tatacatgac atatgtccat
      1330       1340       1350       1360       1370       1380
ccgttcgttt tttctctcgc aactatcatt ccaatggtcc ctgatgaggt tttacgcaaa
      1390       1400       1410       1420       1430       1440
gggagtggca ccctttgtga aatgcttttg atggttgagg cttacaaggc aaatgttgta
      1450       1460       1470       1480       1490       1500
tgtcccaaca aaaatcaagc tgaccctgag aagttctacc aaggtaaact tcttgaaagt
      1510       1520       1530       1540       1550       1560
gagacatata ttggtggcca tgtagagtgc ctccaaagtg gtgttttcag atctgacatt
      1570       1580       1590       1600       1610       1620
ccaaccagtt ttaagctcga cgcatccgca taccagcaac tgatcgataa ccttggtcgg
      1630       1640       1650       1660       1670       1680
gatctggaat atgctatcac tgttgaagga aaaatgagaa tggattcagt ttccaatttt
      1690       1700       1710       1720       1730       1740
gatgaagtaa aggaagtaat cagggaaaag ctcgagaagt tacgggatga tcctatacgt
      1750       1760       1770       1780       1790       1800
gaagaggggc ctcttattta tcaccttgat gtcgcggcga tgtatccaaa tattatctta
      1810       1820       1830       1840       1850       1860
acaaacaggc ttcagccacc atcaatagtt acggatgagg tttgcacagc atgtgatttc
      1870       1880       1890       1900       1910       1920
aacggcccgg aaaagacctg tcttagaaaa cttgaatggg tttggcgtgg ggtgacgttc
      1930       1940       1950       1960       1970       1980
aagggaaata aaagtgaata ttaccatctg aagaagcaga ttgagtctga atctgttgat
      1990       2000       2010       2020       2030       2040
gctggagcaa atatgcagtc ttcaaaacct tttcttgatc tgccaaaggt ggaacaacaa
      2050       2060       2070       2080       2090       2100
tccaaattaa aagaacgact gaaaaaatac tgtcaaaagg catatagccg agtacttgac
      2110       2120       2130       2140       2150       2160
aagccaatca ctgaagttcg cgaggctggg atatgcatga gagaaaaccc gttctatgtg
      2170       2180       2190       2200       2210       2220
gacactgtgc gcagctttcg agataggagg tatgaataca aaacacttaa caaggtctgg
      2230       2240       2250       2260       2270       2280
aagggaaagt tgtcagaggc caaggcaagt ggcaatttaa tcaagatcca ggaagcacat
      2290       2300       2310       2320       2330       2340
gacatggtag tggtttacga ttccttgcag ctagctcata agtgtatact taattccttt
      2350       2360       2370       2380       2390       2400
tatggatatg tcatgcgaaa gggcgcaaga tggtactcca tggaaatggc tggggtagtt
      2410       2420       2430       2440       2450       2460
acttatactg gagccaaaat catccagaat gctcgtttgc ttattgaacg aattgggaaa
      2470       2480       2490       2500       2510       2520
ccacttgagc tggatacaga tggtatatgg tgtgctctac ctggatcttt tcctgagaac
      2530       2540       2550       2560       2570       2580
tttaccttta aaaccataga tatgaagaaa ttcaccatct cgtatccgtg tgtaatactt
      2590       2600       2610       2620       2630       2640
aatgttgatg tggcgaagaa taattcaaat gaccaatatc agactctagt agatcctgta
      2650       2660       2670       2680       2690       2700
cgaaagacat ataattcacg tagcgaatgc tcaattgaat ttgaagtgga tggaccgtac
      2710       2720       2730       2740       2750       2760
aaggcaatga ttattcctgc atccaaggaa gagggaatct taattaagaa gcggtatgct
      2770       2780       2790       2800       2810       2820
gttttcaatc atgacggaac catagcagaa ctcaaggggt ttgagatgaa gcgtagagga
      2830       2840       2850       2860       2870       2880
gagctgaaac tcattaaagt tttccaggcc gagctatttg acaaatttct gcatggatca
      2890       2900       2910       2920       2930       2940
acccttgaag agtgttattc tgctgttgca gctgttgcaa atcgttggct tgacctactc
      2950       2960       2970       2980       2990       3000
gagggtcaag gaaaagatat tgccgatagt gaattgctag attatatatc agaatcaagc
      3010       3020       3030       3040       3050       3060
actatgagca aatcgttagc agattatggt caacaaaagt catgtgcagt gaccacagca
      3070       3080       3090       3100       3110       3120
aaacgcctgg ctgattttct tggtgataca atggtcaaag ataaaggact gcgctgccaa
      3130       3140       3150       3160       3170       3180
tacatcgttg ctcgtgaacc agaggggaca cctgtaagtg aacgtgctgt ccctgttgcc
      3190       3200       3210       3220       3230       3240
atatttcaaa cagatgatcc tgaaaaaaag ttttatctgc aaaaatggtg caagatatca
      3250       3260       3270       3280       3290       3300
tcatatactg gaatccgttc aattattgac tggatgtatt acaagcagcg tcttcattca
      3310       3320       3330       3340       3350       3360
gctattcaaa aagttattac cattcctgct gcaatgcaga aggtggcaaa tcctgtactt
      3370       3380       3390       3400       3410       3420
agggtgcgtc atccttattg gctcgagaaa aaggtctgtg acaaatttcg tcagggaaaa
      3430       3440       3450       3460       3470       3480
atagttgata tgtttagctc agcaaacaaa gatcattcga caactcaaga taatgtagtg
      3490       3500       3510       3520       3530       3540
gcggatattg aagagttttg caaagaaaac agaccttccg taaaagggcc aaagccagtt
      3550       3560       3570       3580       3590       3600
gcgcgttcat ttgaagtcga tagaaatcac tctgagggta agcagcaaga gagttgggat
      3610       3620       3630       3640       3650       3660
ccagagttcc atgatatctc attacagaac gttgacaaga atgtagatta ccaaggatgg
      3670       3680       3690       3700       3710       3720
cttgaactgg aaaaaagaaa atggaaaatg actctaacga ataagaaaaa aagaaggtac
      3730       3740       3750       3760       3770       3780
tcctcaagtt tatttggttt tgatttggaa caaaatataa ataaaaaagt ctgtaaggga
      3790       3800       3810       3820       3830       3840
agagtaggtg taggctcata ctttaggagg cctgaagaag ctttgactag ttcctatttg
      3850       3860       3870       3880       3890       3900
cagataatac agttggtcca aagtccacag agcgggcaat tttttgcttg ggttgttgtg
      3910       3920       3930       3940       3950       3960
gaaggattga tgcttaagat cccattgacg atcccaaggg tgttttacat taattccaaa
      3970       3980       3990       4000       4010       4020
gcttctatag ctggaaactt cacgggaaag tgtatcaaca agattcttcc tcacggaaag
      4030       4040       4050       4060       4070       4080
ccttgttaca atttgatgga ggtcaatatt caggaagatc aatttataaa agaaagcaaa
      4090       4100       4110       4120       4130       4140
aagcttgccg ctctacttgc agaccccgaa attgagggca tatatgaaac taagatgcct
      4150       4160       4170       4180       4190       4200
ctggagttta gtgctatatg tcagattgga tgtgtatgca aaattgaaga cacggccaaa
      4210       4220       4230       4240       4250       4260
caccgtaaca cccaagatgg atggaaactt ggtgaacttc acaggataac tacaactgag
      4270       4280       4290       4300       4310       4320
tgtcgctact tggagaattc tattccactt gtttatttgt atcacagcac ctcaacaggt
      4330       4340       4350       4360       4370       4380
cgtgctgttt atgttttata ttgtcatgct tcgaagctta tgtctgttgt ggtagtcaat
      4390       4400       4410       4420       4430       4440
ccttacggtg acaaggaatt attatcatct gccctagaga gacagtttag agatagatgc
      4450       4460       4470       4480       4490       4500
caagaactgt cacctgagcc attttcttgg gatggtatcc ttttccaggt cgagtatgtt
      4510       4520       4530       4540       4550       4560
gaccatccag aagctgccac gaaattttta caaaaagcgc tctgtgaata cagagaagaa
      4570       4580       4590       4600       4610       4620
aattgtggag caactgtggc agtcattgaa tgccctgact ttaacaccac gaaggaaggt
      4630       4640       4650       4660       4670       4680
gtaaaggccc tggaagattt cccatgtgtg aggattccct tcaacgacga tgacaatagt
      4690       4700       4710       4720       4730       4740
tatcagcctg tctcctggca acgtccagca gcaaaaatag cagtgctccg ttgtgcttca
      4750       4760       4770       4780       4790       4800
gcaattcagt ggttggaccg gaggattgcc cagtcaagat acgcccatgt gcctctgggg
      4810       4820       4830       4840       4850       4860
aattttggac gtgattggtt aacgttcaca gtagatatct tcctgtccag ggcactccgt
      4870       4880       4890       4900       4910       4920
gaccagcaac aggttctttg ggtctcagat aatggtgttc cagaccttgg agatataaac
      4930       4940       4950       4960       4970       4980
aatgaagaga catttctagc tgatgagaca agtttgctat tccctggagc gtacagaaaa
      4990       5000       5010       5020       5030       5040
gtgtctgtgg agttaaaggt ccatagatta gctgttaatg cccttctgaa aagtgacctg
      5050       5060       5070       5080       5090       5100
gtgagtgaaa tggaaggagg cggctttttg ggtgtgaatt ctagaggaag tagcttaaac
      5110       5120       5130       5140       5150       5160
gataatggca gttttgatga gaataatgga tgcgcgcaag catttcgtgt cctgaaacaa
      5170       5180       5190       5200       5210       5220
ttgatcaagc gcttgttgca tgatgcgtgt aattctggca atatatatgc tgattccatt
      5230       5240       5250       5260       5270       5280
ttgcaacatc tgtcttggtg gctccgcagc ccttcctcaa agcttcacga tccagctctc
      5290       5300       5310       5320       5330       5340
catctcatgc ttcacaaggt catgcaaaag gtgtttgcgc tgcttttgac tgatttgcgg
      5350       5360       5370       5380       5390       5400
aggttaggtg ctataataat atacgcagac ttctcaaagg tcattatcga cacagggaaa
      5410       5420       5430       5440       5450       5460
tttgatctat ctgctgcaaa gacttattgt gaaagcttgc tcacagtgat ggggagtaga
      5470       5480       5490       5500       5510       5520
gatatcttta agttgatctt gcttgagccg gttcactact ggcactcgtt acttttcatg
      5530       5540       5550       5560       5570       5580
gaccagcata actacgctgg tatccgagct accggagatg aaatttcagg taacgaagtt
      5590       5600       5610       5620       5630       5640
actattgaac caaagtggag cgttgcacgg catttacccg agtatattca gaaggatttt
      5650       5660       5670       5680       5690       5700
atcataattg ttgccacgtt tatatttggc ccctggaaat ttgcattaga gaaaaaaagg
      5710       5720       5730       5740       5750       5760
ggcagtgcag agagtttaga ggcagagatg gtagaatatc tcaaggaaca gataggaacc
      5770       5780       5790       5800       5810       5820
cggttcataa gcatgattgt tgagaagatt ggtaatatca ggtcacacat caaggatata
      5830       5840       5850       5860       5870       5880
aacgtgtcag atgcatcttg ggcttctggt caagctccca aaggagatta cacgttcgaa
      5890       5900       5910       5920       5930       5940
tttatacaaa ttattactgc tgttctggct cttgatcaaa acgttcagca agatgttctg
      5950       5960       5970       5980       5990       6000
gtaatgagaa agattctgtt gaagtacatt aaagtaaaag aatgtgctgc tgaagccgaa
      6010       6020       6030       6040       6050       6060
tttattgatc ctgggccatc cttcatctta cccaacgtgg cttgcagcaa ctgcggtgcc
      6070       6080       6090       6100       6110       6120
tacagagacc tagatttctg cagagactca gctctcttaa cagaaaaaga atggtcatgt
      6130       6140       6150       6160       6170       6180
gcggatccgc aatgtgtgaa gatatatgac aaagagcaga tagagagtag cattatccag
      6190       6200       6210       6220       6230       6240
atggtgagac agagggaaag aatgtaccag ttgcaggatc tagtgtgcaa taggtgcaat
      6250       6260       6270       6280       6290       6300
caggtgaaag ccgctcattt gacagagcag tgtgagtgtt ctggatcctt tagatgcaag
      6310       6320       6330       6340       6350       6360
gagagtggtt cagatttcca caagaggatt gagattttct tggatatagc aaagcgccag
      6370       6380       6390       6400       6410
aagtttagac tgctagaaga atgcatctcc tggattttat ttgccaccag ctgttga

Last modification date: Oct. 2, 2011