Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA polymerase


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MSGDNRRRDR KDTRWSKKPK VVNTAEDELE SKLGFGLFSE GETRLGWLLT FSSSSWEDRD
        70         80         90        100        110        120
TGKVYSCVDL YFVTQDGFSF KTKYKFRPYF YAATKDKMEL ELEAYLRRRY ERQVADIEIV
       130        140        150        160        170        180
EKEDLDLKNH LSGLQKKYLK ISFDTVQQLM EVKRDLLHIV ERNQAKFDAL EAYESILAGK
       190        200        210        220        230        240
REQRPQDCLD SIVDLREYDV PYHVRFAIDN DVRSGQWYNV SISSTDVILE KRTDLLQRAE
       250        260        270        280        290        300
VRVCAFDIET TKLPLKFPDA EYDQIMMISY MVDGQGFLII NRECVGEDVE DLEYTPKPEF
       310        320        330        340        350        360
EGYFKVTNVK NEVELLQRWF YHMQELKPGI YVTYNGDFFD WPFIERRASH HGIKMNEELG
       370        380        390        400        410        420
FRCDQNQGEC RAKFACHLDC FAWVKRDSYL PQGSHGLKAV TKAKLGYDPL EVNPEDMVRF
       430        440        450        460        470        480
AMEKPQTMAS YSVSDAVATY YLYMTYVNPF IFSLATIIPM VPDEVLRKGS GTLCEMLLMV
       490        500        510        520        530        540
EAYKANVVCP NKNQADPEKF YQNQLLESET YIGGHVECLE SGQLIDNLGR DLEYAITVEG
       550        560        570        580        590        600
KMRMDSISNY DEVKDEIKEK LEKLRDDPIR EEGPLIYHLD VAAMYPNIIL TNRLQPPSIV
       610        620        630        640        650        660
TDEICTACDF NRPGKTCLRK LEWVWRGVTF MGKKSDYYHL KKQIESEFVD AGANIMSSKS
       670        680        690        700        710        720
FLDLPKVDQQ SKLKERLKKY CQKAYKRVLD KPITEVREAG ICMRENPFYV DTVRSFRDRR
       730        740        750        760        770        780
YEYKTLNKVW KGKLSEAKAS GNSIKIQEAQ DMVVVYDSLQ LAHKCILNSF YGYVMRKGAR
       790        800        810        820        830        840
WYSMEMAGVV TYTGAKIIQN ARLLIERIGK PLELDTDGIW CCLPGSFPEN FTFKTIDMKK
       850        860        870        880        890        900
LTISYPCVML NVDVAKNNTN DQYQTLVDPV RKTYKSHSEC SIEFEVDGPY KAMIIPASKE
       910        920        930        940        950        960
EGILIKKRYA VFNHDGTLAE LKGFEIKRRG ELKLIKVFQA ELFDKFLHGS TLEECYSAVA
       970        980        990       1000       1010       1020
AVADRWLDLL DNQGKDIADS ELLDYISESS TMSKSLADYG EQKSCAVTTA KRLAEFLGVT
      1030       1040       1050       1060       1070       1080
MVKDKGLRCQ YIVACEPKGT PVSERAVPVA IFTTNPEVMK FHLRKWCKTS SDVGIRLIID
      1090       1100       1110       1120       1130       1140
WSYYKQRLSS AIQKVITIPA AMQKVANPVP RVLHPDWLHK KVREKDDKFR QRKLVDMFSS
      1150       1160       1170       1180       1190       1200
ANKDVVLDTD LPVTKDNVED IEDFCKENRP SVKGPKPIAR SYEVNKKQSE CEQQESWDTE
      1210       1220       1230       1240       1250       1260
FHDISFQNID KSVNYQGWLE LKKRKWKVTL EKKKKRRLGD LRSSNQVDTH EINQKVGQGR
      1270       1280       1290       1300       1310       1320
GGVGSYFRRP EEALTSSHWQ IIQLVPSPQS GQFFAWVVVE GLMLKIPLSI PRVFYINSKV
      1330       1340       1350       1360       1370       1380
PIDEYFQGKC VNKILPHGRP CYSLTEACVK IQEDQFKKES KKRAALLADP GVEGIYETKV
      1390       1400       1410       1420       1430       1440
PLEFSAICQI GCVCKIDNKA KHRNTQDGWE VGELHMKTTT ECHYLKRSIP LVYLYNSTST
      1450       1460       1470       1480       1490       1500
GRAIYVLYCH VSKLMSAVVV DPFNGNELLP SALERQFRDS CLELSLDSLS WDGIRFQVHY
      1510       1520       1530       1540       1550       1560
VDHPEAAKKI IQRAISEYRE ENCGPTVAVI ECPDFTFMKE GIKALDDFPC VRIPFNDDDN
      1570       1580       1590       1600       1610       1620
SYQPVSWQRP AAKIAMFRCA AAFQWLDRRI TQSRYAHVPL GNFGLDWLTF TIDIFLSRAL
      1630       1640       1650       1660       1670       1680
RDQQQVLWVS DNGVPDLGGI NNEEAFFADE VQQTSLVFPG AYRKVSVELK IHNLAVNALL
      1690       1700       1710       1720       1730       1740
KSNLVNEMEG GGFMGFEQDV NPRGINSNDN TSFDETTGCA QAFRVLKQLI HSCLTDVRKS
      1750       1760       1770       1780       1790       1800
KNIYADSILQ RLSWWLCSPS SKLHDPALHL MLHKVMQKVF ALLLTDLRRL GAIIIYADFS
      1810       1820       1830       1840       1850       1860
KVIIDTVKFD LSAAKAYCES LLSTVRNSDI FEWILLEPVH YWHSLLFMDQ YNYAGIRADD
      1870       1880       1890       1900       1910       1920
EISLDEVTIE PKWSVARHLP EYIERDFIII IAKFIFDPWK FAIENKKGSS ESLEAQMIEY
      1930       1940       1950       1960       1970       1980
LREQIGSTFI NMLVKKVDDI MSHMKEINVS DASRVSGQAP KGDYSLEFIQ VISAVLALDQ
      1990       2000       2010       2020       2030       2040
NVQQDVLVMR KSLLKYIKVK ECAAEAEFLD PGPSFILPNV ACSNCDAYRD LDICRDPALL
      2050       2060       2070       2080       2090       2100
TEKEWSCADT QCGKIYDREQ MESSLLEMVR QRERMYHMQD VVCIRCNQVK AAHLTEQCEC
      2110       2120       2130       2140
SGSFRCKESG SEFSKRMEIF MDIAKRQKFR LLEEYISWII YGPSY 

Encoded by TIL1 gene


OTHER NAME(S):
ABA OVERLY SENSITIVE 4
ABO4
EARLY IN SHORT DAYS 7
EMB142
EMB2284
EMB529
EMBRYO DEFECTIVE 142
EMBRYO DEFECTIVE 2284
EMBRYO DEFECTIVE 529
ESD7
POL2A
T23G18.21
T23G18_21
TIL1
TILTED 1


DESCRIPTION:
Similar to POL2A, DNA polymerase epsilon catalytic subunit. Essential for Arabidopsis growth. Null homozygotes are embryo lethal, partial loss of function alleles show embryo patterning defects such as root pole displacement. Delayed progression through cell cycle results in embryos with smaller numbers of larger cells.


Nucleic acid sequence

        10         20         30         40         50         60
atgagcggag ataatcgaag acgggatcga aaggatacgc ggtggtcgaa gaagcctaag
        70         80         90        100        110        120
gtagtgaaca ctgcggaaga tgaactcgaa tctaaactcg gatttgggct tttctctgaa
       130        140        150        160        170        180
ggtgaaaccc gacttgggtg gttactcaca ttctcatcgt catcttggga agatcgcgat
       190        200        210        220        230        240
actgggaaag tctatagttg tgtggacctt tactttgtta ctcaggacgg cttttctttc
       250        260        270        280        290        300
aagacaaagt acaagttccg tccttacttt tatgcagcca cgaaagacaa aatggaattg
       310        320        330        340        350        360
gaactcgaag cctacttgag acgccgatat gaaagacaag ttgctgatat tgagattgtt
       370        380        390        400        410        420
gaaaaagaag atcttgatct taaaaatcat ctatctggcc tgcaaaaaaa atacctaaaa
       430        440        450        460        470        480
atatcatttg atactgtgca acaattgatg gaagtcaagc gggatttgtt acatattgtc
       490        500        510        520        530        540
gaacgaaacc aggcaaaatt tgatgcactt gaagcatacg aatccatatt ggctggaaaa
       550        560        570        580        590        600
cgagaacaac gtcctcaaga ttgcttagac tctatcgtgg acctccgcga gtacgatgta
       610        620        630        640        650        660
ccttatcatg ttcgatttgc aattgataat gatgtgcgga gtgggcaatg gtacaatgtc
       670        680        690        700        710        720
agtatttcca gcaccgatgt catattggag aagaggacag atcttcttca acgcgcagaa
       730        740        750        760        770        780
gtccgtgttt gtgccttcga tatagagaca acaaagcttc cgttgaagtt tcctgatgct
       790        800        810        820        830        840
gaatatgatc aaattatgat gatatcctac atggtcgatg ggcaaggttt tctaattatt
       850        860        870        880        890        900
aacagagagt gtgttggcga agatgtagaa gatctggaat atacaccaaa accagaattt
       910        920        930        940        950        960
gaagggtatt tcaaagttac taatgttaaa aatgaggttg aactcctcca aagatggttt
       970        980        990       1000       1010       1020
taccatatgc aagagttgaa acccggtatt tatgttacat acaacggtga cttttttgac
      1030       1040       1050       1060       1070       1080
tggccattta tagaacggag agcatctcat catgggataa aaatgaatga ggaattggga
      1090       1100       1110       1120       1130       1140
ttccgttgtg atcagaatca aggtgaatgt cgagctaaat tcgcttgtca tttggattgt
      1150       1160       1170       1180       1190       1200
tttgcttggg ttaaacgtga tagctatctt cctcagggaa gccatggtct gaaggctgtt
      1210       1220       1230       1240       1250       1260
acaaaggcaa aactaggtta tgatccactg gaagtgaacc cagaggacat ggttcggttt
      1270       1280       1290       1300       1310       1320
gcgatggaaa agccccagac aatggcctcc tactctgtct ctgatgctgt tgcaacttat
      1330       1340       1350       1360       1370       1380
tacctataca tgacatatgt caatccattc attttttctc tcgcaactat catcccaatg
      1390       1400       1410       1420       1430       1440
gtccctgatg aggttttacg taaagggagt ggcacccttt gtgaaatgct tctgatggtt
      1450       1460       1470       1480       1490       1500
gaggcttaca aggcaaatgt tgtatgtccc aacaaaaatc aagctgaccc tgagaaattc
      1510       1520       1530       1540       1550       1560
taccaaaatc aacttcttga aagtgagaca tatattggtg gtcatgtaga gtgccttgaa
      1570       1580       1590       1600       1610       1620
agtggtcaac tgatcgataa ccttggtcgt gatctggaat atgctatcac tgtagaagga
      1630       1640       1650       1660       1670       1680
aaaatgagaa tggattcaat ttccaattat gatgaagtga aggacgaaat caaggagaag
      1690       1700       1710       1720       1730       1740
cttgagaagt tacgagatga ccctatacgg gaagaggggc ctcttattta tcaccttgat
      1750       1760       1770       1780       1790       1800
gtcgcagcca tgtatccaaa tatcatctta acaaacaggc ttcagccacc atcaatagtt
      1810       1820       1830       1840       1850       1860
acggatgaga tttgcacagc atgtgatttc aaccgcccgg gaaagacctg tcttagaaaa
      1870       1880       1890       1900       1910       1920
cttgaatggg tttggcgtgg tgtgacattc atgggaaaga aaagtgatta ttaccatttg
      1930       1940       1950       1960       1970       1980
aagaagcaga ttgagtctga atttgttgat gctggtgcaa atataatgtc ttcaaaatcg
      1990       2000       2010       2020       2030       2040
ttccttgatc tgccaaaggt ggatcaacaa tctaagctaa aagaacgact aaaaaaatat
      2050       2060       2070       2080       2090       2100
tgtcaaaagg cttataaacg agtacttgac aagccaatta ctgaagttcg tgaagctggg
      2110       2120       2130       2140       2150       2160
atatgcatga gagaaaaccc tttctatgtg gatactgttc ggagctttcg agataggagg
      2170       2180       2190       2200       2210       2220
tatgaataca aaacacttaa caaggtctgg aagggaaaat tgtcagaggc caaggcaagt
      2230       2240       2250       2260       2270       2280
ggtaattcaa tcaagatcca ggaagcacag gacatggtag tggtttacga ttccttgcag
      2290       2300       2310       2320       2330       2340
ctagctcata agtgtatact taattccttc tatggatatg tcatgcgaaa gggtgcaaga
      2350       2360       2370       2380       2390       2400
tggtattcca tggaaatggc tggtgtagtt acctatactg gagccaaaat catacagaat
      2410       2420       2430       2440       2450       2460
gcccgtttgc ttattgagcg aattgggaaa ccacttgagt tggatacaga tggtatatgg
      2470       2480       2490       2500       2510       2520
tgttgtctcc ctggatcttt tcctgagaac tttactttta aaacaataga catgaagaaa
      2530       2540       2550       2560       2570       2580
ctcaccatct cgtatccttg tgttatgctt aatgttgatg tggcaaagaa taatacaaat
      2590       2600       2610       2620       2630       2640
gatcaatatc agactcttgt agatcctgta cgcaagacat ataaatcaca tagtgaatgc
      2650       2660       2670       2680       2690       2700
tcaattgaat ttgaagtaga tggaccgtac aaggcaatga ttattcctgc atcgaaagaa
      2710       2720       2730       2740       2750       2760
gaaggaatct taatcaagaa gcgttatgct gttttcaatc atgatggaac cttagcagaa
      2770       2780       2790       2800       2810       2820
ctcaaggggt ttgagatcaa gcgtagaggg gagctgaaac tcattaaagt tttccaggcc
      2830       2840       2850       2860       2870       2880
gagctttttg acaaatttct ccatggatca actcttgaag agtgttattc tgctgttgca
      2890       2900       2910       2920       2930       2940
gcggttgctg atcgatggct tgacctactc gataatcaag gaaaagatat tgccgatagt
      2950       2960       2970       2980       2990       3000
gaactgctag attatatatc agaatcaagc acaatgagca aatcgttagc agattatggt
      3010       3020       3030       3040       3050       3060
gagcaaaagt catgtgcagt gaccacagca aaacgcctgg ctgaatttct tggtgttaca
      3070       3080       3090       3100       3110       3120
atggtcaaag ataaaggact acgttgccag tacattgttg cttgtgaacc aaagggtaca
      3130       3140       3150       3160       3170       3180
ccggtaagcg aacgtgctgt tcctgttgcc atatttacaa caaatccgga agttatgaag
      3190       3200       3210       3220       3230       3240
tttcatttgc gaaaatggtg caagacatca tcagatgtcg gaattcgtct gattattgac
      3250       3260       3270       3280       3290       3300
tggtcgtatt acaagcagcg ccttagttca gctatccaaa aagttattac cattcctgct
      3310       3320       3330       3340       3350       3360
gcaatgcaga aggtggcaaa tcccgtgcct agggtgcttc atcctgactg gctccataaa
      3370       3380       3390       3400       3410       3420
aaggtccgtg agaaagacga caaatttcgc cagagaaaac tagttgatat gttcagctca
      3430       3440       3450       3460       3470       3480
gcaaataaag atgttgtgtt ggacacagat cttccggtga ctaaagataa tgtggaagat
      3490       3500       3510       3520       3530       3540
attgaggatt tttgcaaaga aaataggcct tccgtcaaag ggccaaagcc aattgcgcgt
      3550       3560       3570       3580       3590       3600
tcctatgaag tcaataaaaa acagtctgaa tgtgagcagc aagagagctg ggatacagag
      3610       3620       3630       3640       3650       3660
ttccatgata tctcatttca gaacattgac aagagcgtaa actaccaagg atggcttgaa
      3670       3680       3690       3700       3710       3720
ctgaaaaaga gaaaatggaa agtaactcta gagaagaaga aaaaacgaag gttgggtgat
      3730       3740       3750       3760       3770       3780
ctaagatctt caaaccaggt tgatactcac gagataaatc aaaaagtcgg tcagggaaga
      3790       3800       3810       3820       3830       3840
ggaggtgtgg gttcatactt taggaggcct gaagaagctt tgactagttc acattggcag
      3850       3860       3870       3880       3890       3900
ataatacagc tggtcccaag tccacagagc ggacaatttt ttgcttgggt ggttgtggaa
      3910       3920       3930       3940       3950       3960
gggttgatgc ttaagatccc attgtcgatc ccaagggtgt tttacattaa ttccaaagtt
      3970       3980       3990       4000       4010       4020
cctatagatg aatatttcca aggaaagtgt gtcaacaaga ttcttcctca tggaaggcct
      4030       4040       4050       4060       4070       4080
tgttatagtt tgactgaggc atgtgtcaag attcaagaag atcaatttaa aaaagaaagt
      4090       4100       4110       4120       4130       4140
aaaaagcgtg cagctcttct tgcagaccct ggagttgagg gcatatatga aactaaggtg
      4150       4160       4170       4180       4190       4200
cctctggagt ttagtgctat atgtcagatt ggatgtgtat gcaaaattga taacaaagcc
      4210       4220       4230       4240       4250       4260
aagcaccgta acacccaaga tggatgggaa gttggtgaac ttcacatgaa aactacaact
      4270       4280       4290       4300       4310       4320
gagtgtcact acttgaagcg ttcaattcca cttgtttact tgtataacag cacctcaaca
      4330       4340       4350       4360       4370       4380
gggcgtgcta tatatgtttt atattgtcat gtatcgaagc ttatgtctgc cgttgtagtt
      4390       4400       4410       4420       4430       4440
gatcctttta acggcaatga attattacca tctgccttag agagacagtt tagagatagt
      4450       4460       4470       4480       4490       4500
tgcctagaat tatcacttga ttcattgtct tgggatggta tccgtttcca ggtgcactac
      4510       4520       4530       4540       4550       4560
gttgaccatc ccgaagctgc caagaagata atacaaagag caataagtga atacagagaa
      4570       4580       4590       4600       4610       4620
gaaaattgtg gaccaactgt tgctgtcatt gaatgccctg actttacctt catgaaggaa
      4630       4640       4650       4660       4670       4680
ggtattaagg ccctagatga tttcccatgt gtgaggattc ccttcaacga cgatgacaat
      4690       4700       4710       4720       4730       4740
agttatcagc ctgtctcctg gcaacgtcca gctgcaaaaa tagcaatgtt ccgttgtgct
      4750       4760       4770       4780       4790       4800
gcagcatttc agtggttgga tcggaggatt acccaatcaa gatacgccca tgtgcctctg
      4810       4820       4830       4840       4850       4860
gggaattttg gacttgattg gctaacattc acaatagata tcttcctatc cagggcactc
      4870       4880       4890       4900       4910       4920
cgtgaccagc aacaggtcct ttgggtgtca gataatggtg ttccagacct tggaggtata
      4930       4940       4950       4960       4970       4980
aacaatgaag aggcattctt tgccgatgag gtgcaacaga caagtttagt attccctgga
      4990       5000       5010       5020       5030       5040
gcgtatagaa aagtgtctgt ggagttaaag atccataact tggctgttaa tgcccttctg
      5050       5060       5070       5080       5090       5100
aaaagcaacc tggtgaatga aatggaagga ggcggtttta tgggatttga acaggatgtg
      5110       5120       5130       5140       5150       5160
aatcctagag gaattaattc aaacgataac accagttttg atgagaccac tggatgtgct
      5170       5180       5190       5200       5210       5220
caagcatttc gtgtcctgaa acagttgatt catagttgct tgactgatgt gcgtaaatct
      5230       5240       5250       5260       5270       5280
aaaaatatat atgctgattc cattttgcaa cgtttgtctt ggtggctctg cagcccttcc
      5290       5300       5310       5320       5330       5340
tcgaagctcc atgatccagc tcttcatctc atgcttcaca aggtcatgca aaaggtgttt
      5350       5360       5370       5380       5390       5400
gcactgctat tgactgattt gcggagatta ggtgctataa taatatatgc agacttctca
      5410       5420       5430       5440       5450       5460
aaggtcatta tcgacacagt gaaatttgat ctatctgcag ctaaggctta ttgtgaaagc
      5470       5480       5490       5500       5510       5520
ttgctatcaa cggtgcggaa tagtgatatc tttgagtgga tattgctcga gccggttcac
      5530       5540       5550       5560       5570       5580
tactggcact cattactttt catggaccag tataactacg ctggtatccg agccgatgat
      5590       5600       5610       5620       5630       5640
gaaatttcac ttgacgaagt gactattgaa ccaaagtgga gtgttgcacg acatttacct
      5650       5660       5670       5680       5690       5700
gagtatattg agagggattt cattataatc attgccaagt ttatatttga cccctggaaa
      5710       5720       5730       5740       5750       5760
tttgcgatag aaaataaaaa gggcagttca gagagtttag aggcacagat gatagaatat
      5770       5780       5790       5800       5810       5820
ctaagagaac agattggatc aaccttcata aatatgcttg tcaaaaaggt tgatgatatc
      5830       5840       5850       5860       5870       5880
atgtcacaca tgaaggagat aaatgtttca gatgcatctc gggtttctgg tcaagctccc
      5890       5900       5910       5920       5930       5940
aaaggagatt actcgttgga atttatacag gttatctctg ctgttctggc tcttgaccaa
      5950       5960       5970       5980       5990       6000
aacgtccagc aagatgttct ggtaatgaga aagagtctgt tgaagtacat taaagtaaaa
      6010       6020       6030       6040       6050       6060
gagtgtgctg ctgaagccga atttcttgat cctgggccat ccttcatctt acctaatgta
      6070       6080       6090       6100       6110       6120
gcttgcagca actgtgatgc ctacagagac ctagatatat gcagagaccc agcactgtta
      6130       6140       6150       6160       6170       6180
acagagaaag aatggtcatg tgcggataca caatgtggga agatatatga cagagagcag
      6190       6200       6210       6220       6230       6240
atggagagta gccttctaga gatggtgaga cagagagaaa gaatgtacca tatgcaggat
      6250       6260       6270       6280       6290       6300
gtagtgtgca ttaggtgcaa tcaggtgaaa gcggctcatt tgacagagca gtgtgagtgt
      6310       6320       6330       6340       6350       6360
tctggttcct ttagatgcaa ggagagtggg tcagagttca gcaagaggat ggagatattc
      6370       6380       6390       6400       6410       6420
atggatatag caaagcgcca gaagtttaga ctgttagaag aatacatctc ttggatcata
      6430
tatggcccta gctattaa    

Last modification date: Oct. 2, 2011