Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA ligase 1


DESCRIPTION:
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity).

STRUCTURE SIMILARITY:
Belongs to the ATP-dependent DNA ligase family.


CATALYTIC ACTIVITY:
ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)


Amino acids sequence

        10         20         30         40         50         60
MQKSITSFFK KKSDATDSPS PPKKVPKIDA KTELPDEPHI KSESASPETK PKVEPMSVDS
        70         80         90        100        110        120
EEKTSPVKNV KKEPKEVDDK TTDKKVTTIG LNSTAATKED VENYDPSADS YHPLKNAYWK
       130        140        150        160        170        180
DKKVTPYLAL ARTFQVIEET KGRLKMIDTL SNFFCSVMLV SPEDLVPSVY LSINQLAPAY
       190        200        210        220        230        240
EGLELGVAET TLMKAICKAT GRNLAHIKSQ TQLTGDLGIV AEQSRVSQRM MFQPAPLNVR
       250        260        270        280        290        300
DVFRKLREIA KLSGQSKMDL VYNMFVACRS SEARFFIRSL IGKLRIGIAE QSLLTALAIG
       310        320        330        340        350        360
LVKKNHIDDC KASKVPDVYK DEIVDTTLLL KTAYCQCPNY DIIIPAILKY DIKELQERCP
       370        380        390        400        410        420
MHPGMPLRPM LAQPTKGVHE VFERFGGMQI TCEWKYDGER AQIHRNEKGE ISIFSRNSEN
       430        440        450        460        470        480
NTAKYPDLIA RSTALLKGDV KSYIIDSEIV AWDVERKQIL PFQVLSTRKR KNVDIEEIKV
       490        500        510        520        530        540
QVCVYIFDLL YINGTALVTK NLSERRKLLL EHFQEVEGEW KFATALDTND IDEVQQFLEE
       550        560        570        580        590        600
SIKGNCEGLM VKTLDEEATY EIAKRSRNWL KLKKDYLSNV GDSLDLVVIG GYKGKGRRTG
       610        620        630        640        650        660
TYGGFLLACY DTENEEYQSI CKIGTGFTDE DLQTHSEFLG KHVTSAAKSY YRYDPSLEPD
       670        680        690        700        710        720
HWFEPVQVWE VKCADLSLSP IHRAAIGIVD GERGISLRFP RFIRIRDDKN SENATDANQV
       730        740
AHMYQSQDQV KNNQKSSTQM EMEDEFY   

Encoded by CG5602 gene


OTHER NAME(S):
Dmel\CG5602


Nucleic acid sequence

        10         20         30         40         50         60
atgcaaaagt ctataacctc cttcttcaag aagaaatccg atgccaccga cagcccctcg
        70         80         90        100        110        120
ccgcccaaga aagttcctaa gattgatgcg aagaccgaac tcccagatga accccacatc
       130        140        150        160        170        180
aagagcgaaa gtgcctcccc ggaaactaag cccaaggtag aacctatgtc tgtggattcc
       190        200        210        220        230        240
gaggagaaga caagtccggt gaaaaatgtt aagaaggaac caaaggaagt cgatgacaag
       250        260        270        280        290        300
accactgaca agaaggtcac aaccataggt ctcaactcca ctgccgctac taaggaggat
       310        320        330        340        350        360
gtggaaaact acgatccatc cgccgactcc tatcatccgc tcaagaatgc ctactggaag
       370        380        390        400        410        420
gacaaaaagg tcactcccta cttggcactg gcccgcacat ttcaagtaat cgaggagacc
       430        440        450        460        470        480
aaaggccggc tcaagatgat cgacacgctg agcaacttct tctgctctgt gatgctggtc
       490        500        510        520        530        540
agtccggagg atcttgtgcc cagcgtctac ctcagcatca accaactggc gcccgcctac
       550        560        570        580        590        600
gagggactgg agctgggcgt tgccgagacc accttgatga aggccatttg caaggcaacg
       610        620        630        640        650        660
gggcgtaatt tggctcacat taaatcgcag acgcagctaa ccggggatct gggcatcgtg
       670        680        690        700        710        720
gccgagcagt cgcgcgtttc acagcgcatg atgttccagc cagcgcctct gaatgtgagg
       730        740        750        760        770        780
gatgtgttcc ggaagctacg cgaaatagcc aagctatccg gtcagtcgaa aatggacctg
       790        800        810        820        830        840
gtgtacaata tgtttgtggc ctgtcgatcg tcggaggctc gcttctttat ccgttcattg
       850        860        870        880        890        900
attggcaagc taagaattgg cattgcagag cagagtttgc tcacagcgct ggccattggt
       910        920        930        940        950        960
ttggtgaaaa agaaccacat cgatgattgc aaggctagca aggtgccgga tgtgtataag
       970        980        990       1000       1010       1020
gatgaaatag tcgacaccac tttgctgttg aaaactgcat actgtcagtg tcccaactac
      1030       1040       1050       1060       1070       1080
gatatcatta taccggccat tctaaagtac gatattaagg agctgcagga acgctgcccc
      1090       1100       1110       1120       1130       1140
atgcatcccg gcatgccgct gaggcccatg ctcgcccagc ccaccaaggg ggtccatgag
      1150       1160       1170       1180       1190       1200
gtatttgaga gattcggcgg catgcaaatc acctgcgagt ggaaatacga tggagagcgg
      1210       1220       1230       1240       1250       1260
gcccaaatcc accgcaacga gaagggggag atcagcatat tctcgcgcaa ctccgagaac
      1270       1280       1290       1300       1310       1320
aacacggcaa aatatccgga tttgattgcc aggagcactg ccttgctcaa gggcgacgta
      1330       1340       1350       1360       1370       1380
aagtcctaca tcatagacag cgaaattgtg gcctgggatg tggagcgcaa gcagattctg
      1390       1400       1410       1420       1430       1440
ccgtttcagg tgctcagcac gcgcaaacgg aagaacgttg atatcgagga aatcaaggtc
      1450       1460       1470       1480       1490       1500
caagtctgtg tctacatctt cgatctgctg tacatcaatg gcactgctct ggtgaccaaa
      1510       1520       1530       1540       1550       1560
aacctgtcgg agcgtcgcaa gctcctgttg gagcactttc aagaggtcga gggcgagtgg
      1570       1580       1590       1600       1610       1620
aagttcgcca ctgctctgga caccaatgac atagacgaag tgcagcagtt cctggaggag
      1630       1640       1650       1660       1670       1680
tctatcaaag gaaattgcga gggcctcatg gtcaaaacat tggatgagga ggccacctat
      1690       1700       1710       1720       1730       1740
gagattgcca agagatcccg caactggctg aaattgaaga aggactacct atccaatgtg
      1750       1760       1770       1780       1790       1800
ggcgactcac tcgatttggt ggtcattggt ggctacaaag gcaagggccg gcgaactgga
      1810       1820       1830       1840       1850       1860
acctacggag gatttttgct tgcctgctat gacaccgaaa acgaggagta tcagagcata
      1870       1880       1890       1900       1910       1920
tgcaagattg gaactggctt cactgatgag gacctgcaaa cgcattccga gtttttgggc
      1930       1940       1950       1960       1970       1980
aaacatgtga ccagcgccgc caaatcctac tacagatacg accccagcct ggagcccgat
      1990       2000       2010       2020       2030       2040
cactggtttg aaccggtcca ggtgtgggaa gtcaaatgcg cggatctgtc gctcagtccg
      2050       2060       2070       2080       2090       2100
atccaccgag cagccattgg cattgtggac ggagagcggg gcatttcctt gagattccct
      2110       2120       2130       2140       2150       2160
cggttcattc ggatacgcga cgacaagaat agcgaaaacg caacggacgc caatcaggtg
      2170       2180       2190       2200       2210       2220
gcccacatgt accagtcgca ggatcaggtt aaaaataatc aaaagtcgag cacacaaatg
      2230       2240
gagatggagg acgagttcta ctga   

Last modification date: Dec. 5, 2011