Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA topoisomerase


DESCRIPTION:
Evidence at transcript level.

STRUCTURE SIMILARITY:
Belongs to the prokaryotic type I/III topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


PROTEIN TYPE(S):
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication
homologous recombination (HR)
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MSRRGGGPVT VLNVAEKPSV AKSVAGILSR GTFRTREGRS RYNKIFEFDY AINGQPCRML
        70         80         90        100        110        120
MTSVIGHLME LEFADRYRKW HSCDPADLYQ APVMKHVPED KKDIKKTLEE EARKSDWLVL
       130        140        150        160        170        180
WLDCDREGEN IAFEVVDVCR AVKHNLFIRR AHFSALIDRD IHEAVQNLRD PNQLFAEAVD
       190        200        210        220        230        240
ARQEIDLRIG ASFTRFQTML LRDRFAIDST GEERSRVISY GPCQFPTLGF IVERYWEIQA
       250        260        270        280        290        300
HEPEEFWTIN CSHQSEEGLA TFNWMRGHLF DYASAVILYE MCVEEPTATV MNVPHPRERF
       310        320        330        340        350        360
KYPPYPLNTI ELEKRASRYF RLSSEHTMKV AEELYQAGFI SYPRTETDSF SSRTDLRAMV
       370        380        390        400        410        420
EEQTRHPAWG SYAQRLLEPE GGLWRNPANG GHDDKAHPPI HPTKFSSGES NWSRDHLNVY
       430        440        450        460        470        480
ELVVRHYLAC VSQPAVAAET TVEIDIAGER FSASGRAILA KNYLEVYRFE SWGGSVIPVY
       490        500        510        520        530        540
EKGQQFIPTT LTLDAAVTRP PPLLCEADLL SCMDKAGIGT DATMHDHIKK LLDRGYATKD
       550        560        570        580        590        600
ANTRFSPTNL GEALVMGYDD MGYELWKPNL RALMEHDMNE VSVGRKTKAE VLETCLQQMK
       610        620        630        640        650        660
ACFLDARVKK SKLLEAMTIF FERSNNTDES ESQTAGEVVR RCNLCNESDM ALRKNRDGNF
       670        680        690        700        710        720
MVGCMNYPQC RNAVWLPGPT LEASVTTNVC QSCGPGPVYK ILFKFRQIGI PPGFDVNHLG
       730        740        750        760        770        780
CVGGCDDILK QLIDICGTGS RSQARRTPGT APSNNIQGSN TRQSNVCIHC QQRGHASTNC
       790        800        810        820        830        840
PSRVPASRNS RPTATNPRND ESTVSCNTCG SQCVLRTANT EANRGRQFFS CPTQGCSFFA
       850        860        870        880        890        900
WEDSINNSSG NATTGSNSGG SGRRGSRGRG RGGRGGQSSG GRRGSGTSFV SATGEPVSGI
       910        920
RCFSCGDPSH FANACPNRNN SNGNYF   

Encoded by TOP3A gene


OTHER NAME(S):
MGI19.16
TOP3A
topoisomerase 3alpha


Nucleic acid sequence

        10         20         30         40         50         60
atgtcgcgac gaggcggtgg ccccgtgaca gtgttgaacg tggcggagaa gccgtccgtg
        70         80         90        100        110        120
gcgaagtcag tggcggggat tctatcccgt ggaactttcc ggactcggga gggtaggtct
       130        140        150        160        170        180
cggtacaaca aaatcttcga gttcgattac gccatcaatg ggcagccgtg tcgtatgcta
       190        200        210        220        230        240
atgacctccg tcatcggcca cctgatggag cttgagttcg ccgatcgtta ccgcaaatgg
       250        260        270        280        290        300
cactcctgcg acccggcaga tctgtaccaa gctccggtca tgaaacacgt tcccgaggac
       310        320        330        340        350        360
aaaaaggata ttaagaagac attggaggag gaggcaagga aaagcgactg gcttgtgctg
       370        380        390        400        410        420
tggcttgatt gtgataggga aggtgaaaac attgcatttg aagttgtaga tgtttgcaga
       430        440        450        460        470        480
gctgtcaagc ataatctttt tatacgcagg gctcatttct ctgcgttaat tgacagggat
       490        500        510        520        530        540
attcatgaag cagttcagaa tcttagagat cctaatcaat tgtttgctga ggctgtagat
       550        560        570        580        590        600
gctagacaag aaatagacct acgcattggt gcttctttca ctagatttca gactatgctg
       610        620        630        640        650        660
ctgagagata ggtttgctat tgactctacg ggtgaggaga ggagtcgtgt tataagttat
       670        680        690        700        710        720
ggtccgtgtc agtttcctac acttggcttt attgtcgagc gatactggga gatccaggca
       730        740        750        760        770        780
catgaaccag aagagttttg gacaatcaac tgttctcacc aatcagaaga aggccttgcc
       790        800        810        820        830        840
acctttaatt ggatgcgtgg tcatctcttc gattatgctt cagctgtcat attatatgag
       850        860        870        880        890        900
atgtgcgttg aggaacctac tgccactgta atgaatgtcc cacatccaag ggaacgattc
       910        920        930        940        950        960
aagtatcctc cttatccttt gaacacgatt gaacttgaaa aacgtgcttc aagatatttc
       970        980        990       1000       1010       1020
cgtctgagtt cagagcacac catgaaggtg gcagaagaat tatatcaggc tggtttcatc
      1030       1040       1050       1060       1070       1080
agctatcctc gtacggagac cgattctttt tcgagcagga cagatttacg tgctatggtg
      1090       1100       1110       1120       1130       1140
gaggaacaaa caagacatcc tgcatgggga tcatatgcac aaagattatt agaacctgag
      1150       1160       1170       1180       1190       1200
gggggcctct ggagaaaccc tgctaatggt ggtcatgatg acaaggctca cccacccatt
      1210       1220       1230       1240       1250       1260
cacccaacaa agttttctag cggagagtct aactggagca gagatcacct taatgtatat
      1270       1280       1290       1300       1310       1320
gagctagttg tccgccatta cctagcatgt gtttcccagc cagcagttgc tgctgaaact
      1330       1340       1350       1360       1370       1380
acagtcgaga ttgatatcgc tggtgagcgc ttttctgcat ctgggagagc aatattagcc
      1390       1400       1410       1420       1430       1440
aaaaattacc ttgaggtgta ccgctttgaa tcatggggtg gttcagtgat tcccgtgtat
      1450       1460       1470       1480       1490       1500
gaaaaagggc agcagtttat cccaacaact ttgactctcg atgcagctgt aacaaggcca
      1510       1520       1530       1540       1550       1560
ccaccactat tgtgtgaagc tgacttactg agttgtatgg acaaggcagg cattggcacc
      1570       1580       1590       1600       1610       1620
gatgcgacaa tgcacgacca cataaagaaa ctccttgatc ggggttatgc aacaaaggat
      1630       1640       1650       1660       1670       1680
gctaatacac ggttttctcc aaccaacctg ggtgaggcgc ttgtgatggg atatgatgac
      1690       1700       1710       1720       1730       1740
atggggtatg aactttggaa accaaatctc agagccctta tggaacatga tatgaatgaa
      1750       1760       1770       1780       1790       1800
gttagcgttg gcaggaagac caaagctgaa gttcttgaaa catgtttgca gcaaatgaaa
      1810       1820       1830       1840       1850       1860
gcttgtttct tagatgcaag agtaaaaaaa tcaaagctcc tagaagcaat gacaattttc
      1870       1880       1890       1900       1910       1920
tttgaaagat ctaataacac tgatgagagt gaaagtcaga cagctggtga agttgtccga
      1930       1940       1950       1960       1970       1980
cgatgcaatc tctgcaatga atcagatatg gcactcagga agaaccggga tggcaatttc
      1990       2000       2010       2020       2030       2040
atggttgggt gcatgaatta tcctcagtgt cggaatgcag tctggcttcc tggaccgaca
      2050       2060       2070       2080       2090       2100
ttggaagcat ctgtcactac taatgtttgt caatcctgtg gtccaggccc ggtctacaag
      2110       2120       2130       2140       2150       2160
atacttttca agttccgtca aattggaatt ccaccaggct ttgatgttaa tcacttaggt
      2170       2180       2190       2200       2210       2220
tgcgtgggtg gctgtgatga cattcttaaa cagttgatag acatctgtgg aactggatcc
      2230       2240       2250       2260       2270       2280
cgttctcaag caaggagaac tccaggtact gcaccgtcaa acaatatcca aggaagcaac
      2290       2300       2310       2320       2330       2340
acaagacaga gtaatgtctg catacattgt cagcaacgag gacatgcttc cacgaattgt
      2350       2360       2370       2380       2390       2400
ccctcacggg ttccagcatc tcgaaattct cgtcctactg caacaaatcc gagaaacgat
      2410       2420       2430       2440       2450       2460
gaaagtacag tatcatgtaa cacttgtgga tcacaatgtg ttcttcgtac agccaacaca
      2470       2480       2490       2500       2510       2520
gaagctaaca ggggaagaca attcttctca tgtccaacac aaggctgcag tttctttgca
      2530       2540       2550       2560       2570       2580
tgggaagata gcataaacaa cagtagtggg aatgcaacaa cagggtctaa tagcggcggg
      2590       2600       2610       2620       2630       2640
agcggtagac gtggcagccg tggtcgtggc cgtggaggta gaggcggcca aagcagtgga
      2650       2660       2670       2680       2690       2700
ggacgacgcg gctctggaac aagctttgtc tctgcaactg gagagccagt gagtggtata
      2710       2720       2730       2740       2750       2760
aggtgcttct catgtggcga tccttcacat tttgctaacg cttgtcctaa tcgtaataac
      2770       2780
tctaacggta actatttcta a   

Last modification date: Oct. 14, 2011