Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA topoisomerase 2


DESCRIPTION:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity).

STRUCTURE SIMILARITY:
Belongs to the type II topoisomerase family.


CATALYTIC ACTIVITY:
ATP-dependent breakage, passage and rejoining of double-stranded DNA.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MATKLPLQNS NAANVAKAPA KSRAAAGGKT IEEMYQKKSQ LEHILLRPDT YIGSIEKHTQ
        70         80         90        100        110        120
TLWVYEKDEM VQRPVTYVPG LYKIFDEILV NAADNKQRDA KMDSVQVVID VEQNLISVCN
       130        140        150        160        170        180
SGAGVPVEIH QEEGIYVPEM IFGHLLTSSN YDDNVKKTTG GRNGYGAKLT NIFSTEFIIE
       190        200        210        220        230        240
TADGKRLKKY KQVFENNMGK KSEPVITKCN KSENWTKVTF KPDLKKFNMT ELEDDVVALM
       250        260        270        280        290        300
SKRVFDIAGC LGKSVKVELN GKQIPVKSFT DYVDLYLSAA NKSRTEDPLP RLTEKVNDRW
       310        320        330        340        350        360
EVCVSLSEGQ FQQVSFVNSI ATIKGGTHVD YVTSQITNHI VAAVNKKNKN ANVKAHNVKN
       370        380        390        400        410        420
HLWVFVNALI DNPAFDSQTK ETLTLRQSSF GSKCELSEDF LKKVGKSGVV ENLLSWADFK
       430        440        450        460        470        480
QNKDLKKSDG AKTGRVLVEK LDDAAEAGGK NSRLCTLILT EGDSAKSLAL AGRSVLGNNY
       490        500        510        520        530        540
CGVFPLRGKL LNVREASTTQ ITNNKEIENL KKILGLKQNM KYENVNSLRY GQMMIMTDQD
       550        560        570        580        590        600
HDGSHIKGLL INFIHSFWPS LLQVPSFLVE FITPIVKATR KGTKKVLSFY SMPEYEEWKE
       610        620        630        640        650        660
SLKGNATGWD IKYYKGLGTS TAEEGKEYFS NLGLHKKDFV WEDEQDGEAI ELAFSKKKIE
       670        680        690        700        710        720
ARKNWLSSYV PGNHLDQRQP KVTYSDFVNK ELILFSMADL QRSIPSMVDG LKPGQRKILF
       730        740        750        760        770        780
VAFKKIARKE MKVAQLVGYV SLLSAYHHGE QSLASAIIGM AQDYVGSNNI NLLLPNGQFG
       790        800        810        820        830        840
TRTSGGKDSA SARYIFTKLS PVTRILFPKD DDLLLDYLNE DGQRIEPTWY MPIIPTVLVN
       850        860        870        880        890        900
GAEGIGTGWS TFIPNYNPRE IVANVRRLLN GESMVPMDPW YRGFKGTIEK TASKEGGCTY
       910        920        930        940        950        960
TITGLYEEVD ETTIRITELP IRRWNDDYKN FLQSLKTDNG APFFQDVKAY NDEKSVDFDL
       970        980        990       1000       1010       1020
ILSEENMLAA RQEGFLKKFK LTTTIATSNM HLFDKKGVIK KYVTPEQILE EFFDLRFEYY
      1030       1040       1050       1060       1070       1080
EKRKETVVKN MEIELLKLEN KARFILAVLS GEIIVNKRKK ADIVEDLRQK GFTPFPRKAE
      1090       1100       1110       1120       1130       1140
SVEAAIAGAV DDDAAEEPEE ILVDPESSSS YIPGSEYDYL LAMAIASLTI EKVEELLADR
      1150       1160       1170       1180       1190       1200
DKMIIAVADM KKTTPKSLWL SDLESLDKEL EKLDLKDAQV QQAIEAAQKK IRAKSGAAVK
      1210       1220       1230       1240       1250       1260
VKRQAPKKPA PKKTTKKASE SETTEASYSA MDTDNNVAEV VKPKGRQGAK KKAPAAAKEV
      1270       1280       1290       1300       1310       1320
EEDEMLDLAQ RLAQYNFGSA PADSSKTAET SKAIAVDDDD DDVVVEVAPV KKGGRKPAAT
      1330       1340       1350       1360       1370       1380
KAAKPPAAPR KRGKQTVAST EVLAIGVSPE KKVRKMRSSP FNKKSSSVMS RLADNKEEES
      1390       1400       1410       1420       1430
SENVAGNSSS EKSGGDVSAI SRPQRANRRK MTYVLSDSES ESANDSEFDD IEDDEDDE

Encoded by TOPII gene


OTHER NAME(S):
ATTOPII
TOPII
topoisomerase II
TOPOISOMERASE II


DESCRIPTION:
Encodes a topoisomerase II that is highly expressed in young seedlings. The protein is localized in the nucleus and gene expression levels are increased in proliferative tissues.


Nucleic acid sequence

        10         20         30         40         50         60
atggctacca aacttcccct tcaaaacagc aatgccgcca atgttgcgaa agctccggct
        70         80         90        100        110        120
aaatctcgag ctgccgccgg cgggaagacg atcgaggaaa tgtatcagaa gaaatcgcag
       130        140        150        160        170        180
cttgaacaca ttcttctccg tcctgataca tacatcggat ctatcgagaa acacacccaa
       190        200        210        220        230        240
acactttggg tttatgagaa agatgagatg gttcaacgtc ctgttaccta tgtacctgga
       250        260        270        280        290        300
ttgtataaga tctttgatga gattctcgta aacgccgctg ataacaaaca gagagatgcg
       310        320        330        340        350        360
aagatggatt ccgttcaagt tgtgattgat gttgagcaga atctgattag tgtttgtaac
       370        380        390        400        410        420
agtggagctg gagttcctgt agagattcat caggaagaag gaatttatgt accggagatg
       430        440        450        460        470        480
atatttggtc atttgttgac gagtagtaac tacgatgata atgtgaagaa gaccactggt
       490        500        510        520        530        540
ggaagaaacg gatatggtgc taagcttact aatatcttct ctactgaatt catcatcgag
       550        560        570        580        590        600
actgcagatg ggaagagact caagaagtat aagcaggtct ttgagaacaa catggggaag
       610        620        630        640        650        660
aaatctgaac cggttataac caagtgtaat aagagtgaga actggacgaa ggttacattc
       670        680        690        700        710        720
aaaccagatt tgaagaagtt taacatgact gaattagaag acgatgtggt tgctctaatg
       730        740        750        760        770        780
agtaagcgag tgtttgatat tgctggatgt ttggggaagt ctgtcaaagt tgagctgaat
       790        800        810        820        830        840
gggaaacaaa taccagtgaa gtcattcact gattatgttg acctatacct aagtgcagct
       850        860        870        880        890        900
aataaatcga ggacggagga tcctctccca aggttgactg agaaagttaa tgatagatgg
       910        920        930        940        950        960
gaggtttgtg tgagcttaag tgaaggacaa tttcagcagg tcagctttgt caactccata
       970        980        990       1000       1010       1020
gcaacaatca agggtggtac acatgttgac tatgtgacga gtcagattac aaaccatatt
      1030       1040       1050       1060       1070       1080
gtggctgctg tgaacaaaaa gaataaaaac gcaaatgtta aggcccataa tgtgaaaaac
      1090       1100       1110       1120       1130       1140
catctgtggg tctttgtcaa tgcattgatt gacaatcctg cttttgattc tcaaacaaaa
      1150       1160       1170       1180       1190       1200
gaaacactga ctcttcgaca gagcagtttt gggtcgaaat gtgaactttc agaagatttt
      1210       1220       1230       1240       1250       1260
ctgaagaaag ttggaaaatc tggcgtagtg gagaatttgc tttcatgggc agatttcaag
      1270       1280       1290       1300       1310       1320
cagaacaaag atctaaagaa aagtgatgga gccaaaacag ggagggttct agttgagaag
      1330       1340       1350       1360       1370       1380
ttagacgatg ccgccgaagc tggagggaag aactctcgac tctgtacgtt aattttgact
      1390       1400       1410       1420       1430       1440
gaaggagact cagcaaaatc tctcgctttg gcggggaggt ctgtcttggg taataactac
      1450       1460       1470       1480       1490       1500
tgcggtgtgt ttccgcttcg aggaaagcta ttgaatgtca gggaagccag caccactcag
      1510       1520       1530       1540       1550       1560
attacaaaca ataaggaaat tgagaacctc aagaagatcc ttggactaaa gcaaaatatg
      1570       1580       1590       1600       1610       1620
aagtacgaga atgttaactc attaagatat ggccagatga tgatcatgac tgatcaagat
      1630       1640       1650       1660       1670       1680
catgatggtt ctcatataaa gggtctctta atcaatttta tccactcttt ttggccgtcg
      1690       1700       1710       1720       1730       1740
ttactccagg ttccatcatt cctggttgag tttataacac ccattgtgaa ggctacgcgt
      1750       1760       1770       1780       1790       1800
aagggtacaa aaaaagttct gtcattctac tcaatgcctg aatacgaaga atggaaagaa
      1810       1820       1830       1840       1850       1860
agtctgaagg gtaatgcaac cgggtgggat atcaaatact acaaggggtt gggtacaagt
      1870       1880       1890       1900       1910       1920
acggctgagg agggcaaaga gtactttagt aatcttggtc ttcacaaaaa ggattttgtt
      1930       1940       1950       1960       1970       1980
tgggaggatg aacaagatgg agaagccatt gaacttgctt tcagtaaaaa gaagatcgaa
      1990       2000       2010       2020       2030       2040
gcccggaaaa attggctttc gagctatgtg cctggcaatc atcttgatca gagacaaccg
      2050       2060       2070       2080       2090       2100
aaagttacgt acagtgactt cgtgaacaaa gaactgatct tgttctccat ggcggatctt
      2110       2120       2130       2140       2150       2160
caacggtcaa ttccctcaat ggttgatggg ctcaaaccgg gtcagagaaa gatacttttc
      2170       2180       2190       2200       2210       2220
gttgcattca agaaaatcgc tcgtaaagaa atgaaggttg cccagctcgt tggttatgta
      2230       2240       2250       2260       2270       2280
tcattgctgt cagcttatca tcatggcgag cagagtcttg ccagtgctat cataggcatg
      2290       2300       2310       2320       2330       2340
gcgcaggatt acgtgggcag caacaatatc aacttacttc taccaaatgg tcaatttggt
      2350       2360       2370       2380       2390       2400
acacgaactt cgggtggaaa agattcagct agtgcaagat acattttcac taagctctct
      2410       2420       2430       2440       2450       2460
ccagtaacaa ggatcttgtt tcccaaggat gatgatctcc ttcttgatta cttgaatgaa
      2470       2480       2490       2500       2510       2520
gacgggcaaa ggatagagcc aacttggtac atgcccatca ttccaactgt acttgtcaat
      2530       2540       2550       2560       2570       2580
ggcgctgaag gcattggaac tgggtggagc acgttcatac caaactataa ccctagagag
      2590       2600       2610       2620       2630       2640
atcgttgcta atgtaaggcg tttacttaac ggtgaaagta tggtgcctat ggatccttgg
      2650       2660       2670       2680       2690       2700
tatagaggtt ttaaaggaac aattgagaaa actgcgtcca aagaaggtgg ttgtacttac
      2710       2720       2730       2740       2750       2760
acaatcactg gtctatatga ggaggtggat gaaacaacta ttcgaatcac ggagttgcca
      2770       2780       2790       2800       2810       2820
atcagaaggt ggaatgatga ttacaaaaat ttcttgcagt cattgaagac agataatggt
      2830       2840       2850       2860       2870       2880
gcaccttttt tccaggatgt caaggcttac aatgacgaga aatctgttga ttttgacctt
      2890       2900       2910       2920       2930       2940
attttgagtg aagagaacat gctggcggct cggcaagagg gctttctgaa gaaattcaaa
      2950       2960       2970       2980       2990       3000
ctcaccacga caatcgctac aagtaatatg catctctttg ataaaaaagg tgtgataaag
      3010       3020       3030       3040       3050       3060
aaatatgtga ccccagaaca aatccttgaa gagttctttg acctcaggtt tgaatactat
      3070       3080       3090       3100       3110       3120
gagaagagaa aggaaaccgt ggtgaagaat atggaaattg agctgttgaa actagaaaac
      3130       3140       3150       3160       3170       3180
aaagcgaggt ttattcttgc agttctcagt ggagaaatca tagtgaacaa gaggaagaaa
      3190       3200       3210       3220       3230       3240
gccgatattg ttgaggactt aagacagaaa gggttcacac catttccgag gaaggccgag
      3250       3260       3270       3280       3290       3300
tctgtcgaag ctgcaattgc tggagcagtt gatgatgatg cagctgaaga acctgaagaa
      3310       3320       3330       3340       3350       3360
atcttagtgg atccggagtc aagctccagt tatatacccg gctcggaata tgactaccta
      3370       3380       3390       3400       3410       3420
ttggcaatgg ctatagcttc gttgactata gagaaagttg aggagttatt agcagacaga
      3430       3440       3450       3460       3470       3480
gataaaatga ttattgcagt tgcagacatg aagaaaacca caccgaaatc cctctggctc
      3490       3500       3510       3520       3530       3540
agtgacctag agtctcttga caaggaacta gaaaaacttg atctgaaaga tgctcaagtc
      3550       3560       3570       3580       3590       3600
caacaggcta tagaggcagc acagaaaaaa atcagggcca aatctggagc agcagtaaag
      3610       3620       3630       3640       3650       3660
gttaaaaggc aggcaccaaa gaaaccagca ccaaagaaga ccacaaagaa agccagtgaa
      3670       3680       3690       3700       3710       3720
tctgagacaa cagaggcttc ctattcagca atggacacag ataacaacgt agcagaagtg
      3730       3740       3750       3760       3770       3780
gtgaagccaa aaggtagaca aggagcaaag aagaaggctc cagcagctgc gaaggaggtt
      3790       3800       3810       3820       3830       3840
gaggaggatg aaatgttgga tctagcacaa cggcttgctc aatacaattt cggctcagca
      3850       3860       3870       3880       3890       3900
cctgcggatt caagcaaaac agctgaaaca tcgaaagcaa ttgctgtgga tgacgatgat
      3910       3920       3930       3940       3950       3960
gatgacgtgg tagttgaggt tgcaccagta aagaaaggag gaaggaaacc ggcggcgact
      3970       3980       3990       4000       4010       4020
aaagctgcaa aaccaccagc agctccgagg aaacgaggga agcagacagt tgcttcaaca
      4030       4040       4050       4060       4070       4080
gaggttctgg caattggtgt gtccccggag aagaaagtga ggaagatgag atcatctccg
      4090       4100       4110       4120       4130       4140
ttcaacaaga agagtagttc agtgatgagc aggttggctg ataataagga agaggagagc
      4150       4160       4170       4180       4190       4200
agcgagaatg tggctggaaa ctcatcgtct gagaaatctg gaggagatgt ttctgcgata
      4210       4220       4230       4240       4250       4260
tcgaggcctc aaagagctaa taggaggaaa atgacctatg tgttgagtga ttccgagagt
      4270       4280       4290       4300       4310
gaatctgcga atgattctga gtttgatgac attgaagacg atgaagatga tgagtag

Last modification date: Oct. 2, 2011