Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: Putative DNA topoisomerase 2, mitochondrial


DESCRIPTION:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity).

STRUCTURE SIMILARITY:
Belongs to the type II topoisomerase family.


SUBUNIT STRUCTURE:
Homodimer (By similarity).


CATALYTIC ACTIVITY:
ATP-dependent breakage, passage and rejoining of double-stranded DNA.


PROTEIN TYPE(S):
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MYILKNKFLR ETARISVWNN GSGLPVEIHP TEGIYVPTLV FGNLFTSSNY DDSEIKTVGG
        70         80         90        100        110        120
RNGYGAKLCN IFSKEFIVET VDTRIKRRFR QKWYDNMKKC NEAEVVEILD ETVKDYTKVE
       130        140        150        160        170        180
FVPDLERFQI DKLSDDVIDL IGRRVFEVAA TLPRDVDVYL NGQKCDVDGF EDYVKMFNDS
       190        200        210        220        230        240
SSLLFLHPTP RWHVGVAKRN NFFGESHVVL PKIVSFVNNI NTEKGGSHVD YVMDKIVNII
       250        260        270        280        290        300
KPIVDSKLGD PTKSVKPAVI KNNLSIFINC LIENPSFESQ TKETLTTKAK NFGSIFECDA
       310        320        330        340        350        360
KKTAEWAEQS GLIEDIVEEV LNMKKKKLPG KRVSVSSVRD IVKLEDAEWA GITGTAEKCT
       370        380        390        400        410        420
LILTEGDSAK ALALAGLEVL GRETYGVFPL KGKLLNVSNL DDARASKNEE ISNLLRILGL
       430        440        450        460        470        480
KFEDSNSITR ESLRYGRLLI LADQDEDGSH IKGLIVNFIH KFWPSLVHTD GFIQSFRTPL
       490        500        510        520        530        540
LKAKKGDKVR SFFSMNEYRK WADVEEGGKW KIKYYKGLGT STSNEAREYF SDLDHHTVNF
       550        560        570        580        590        600
KYTGTTDDDA IRMAFDRDKS DERKEWIRRS ENEITNEDDG KTEISYQEFV DGQLMQFGMV
       610        620        630        640        650        660
DLKRSIPSLI DGLKPSQRKI LWTLLNNMDE STEIKVSQLA GAVAHRQSYH HGEESLVRTI
       670        680        690        700        710        720
IRMGQTFCGS SNLPLLQPIG QFGTRHEGGN DAASARYIFT ALAPTTRLLF PQADDDLLQK
       730        740        750        760        770        780
NVEEGMVVEP TWLCPIVPLI LINGTEGIGT GWSTKIANRN PIDIIDMIRR KIDSISTEYE
       790        800        810        820        830        840
IPPFYEEFRG KLEVVTPTKF ISSGKIQLIR PERKNASTFS IEIVELPIGI WTSKYKEKLS
       850        860        870        880        890        900
KIVETLPVLE FSERHTEKRV HFRITLDRKK SSRFLQKSNS DLLNYFKLRT SLTENRVLFD
       910        920        930        940        950        960
RNGELKEFGN ISEIAAEFFE VRRDLYEKRL KIQKEECEAK LIYVENQLNF IEMVTNGTIE
       970        980        990       1000       1010       1020
IRSMGRNQLE EKLQEMGFRV DPMATIAKNS KKANYGYLLE MPVSRLTSDE MKRLEERKSR
      1030       1040       1050
RRTELEAAES ADWKSVWRSE LDKLAEAVGN NRKS  

Encoded by gid:176184 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtatatcc ttaaaaataa atttttaaga gaaaccgcac gaatatcggt atggaataac
        70         80         90        100        110        120
ggaagcggac ttccagtgga aattcatcca accgaaggaa tttatgttcc aacgcttgtc
       130        140        150        160        170        180
tttggaaatt tattcacttc atcaaattat gatgattctg aaattaaaac agttggtgga
       190        200        210        220        230        240
agaaatggat atggtgcaaa actttgtaat attttctcaa aggaatttat cgttgaaaca
       250        260        270        280        290        300
gtggatacaa gaataaaacg acggtttaga cagaaatggt atgacaatat gaaaaagtgt
       310        320        330        340        350        360
aatgaggcgg aagttgtcga gattttagat gaaacagtca aagactacac taaagtcgaa
       370        380        390        400        410        420
tttgttcctg atcttgaacg tttccaaata gataaactct ccgatgacgt catcgatctt
       430        440        450        460        470        480
atcggaagac gtgtatttga agttgctgca actcttccac gagatgttga tgtttaccta
       490        500        510        520        530        540
aatggccaaa aatgtgatgt agacggattc gaagattatg taaaaatgtt caatgactct
       550        560        570        580        590        600
tcgtctcttc tatttcttca tccaacacct cgatggcatg tgggcgtggc caaacggaat
       610        620        630        640        650        660
aatttctttg gagaatctca tgtggtcctt ccgaaaattg ttagcttcgt gaataatatc
       670        680        690        700        710        720
aacacggaga aagggggaag ccacgtggat tatgtgatgg ataaaatagt gaatattatc
       730        740        750        760        770        780
aagccaatcg tagattcaaa gttaggagat cctacgaaaa gtgtgaaacc agcagttatc
       790        800        810        820        830        840
aagaataatt tgtctatatt tatcaattgt ctcattgaaa atccatcttt tgaaagtcaa
       850        860        870        880        890        900
actaaagaaa ctttgacgac gaaagccaag aattttggat caatttttga atgtgatgcg
       910        920        930        940        950        960
aagaaaacag cagaatgggc ggaacagagt ggattaatag aggatattgt ggaagaagta
       970        980        990       1000       1010       1020
ttgaatatga aaaagaagaa attaccagga aaacgagttt cagtgtcttc agttcgagat
      1030       1040       1050       1060       1070       1080
attgtcaagc tagaagacgc tgaatgggct ggaattacgg gaacggcaga gaagtgcaca
      1090       1100       1110       1120       1130       1140
ttgattctca cagaaggtga ttcggcgaaa gctttggctc ttgccggctt agaagttctg
      1150       1160       1170       1180       1190       1200
ggacgtgaaa cttatggagt atttccactg aaaggaaaac tgttgaacgt atcaaatcta
      1210       1220       1230       1240       1250       1260
gatgacgccc gtgcatcgaa gaatgaagaa atttcgaatc ttctccgaat tcttggattg
      1270       1280       1290       1300       1310       1320
aaatttgaag attcgaactc aataactcgc gagtctcttc gatacggtcg actcttgatt
      1330       1340       1350       1360       1370       1380
ttggcggatc aggatgagga tggcagtcac atcaagggac taattgttaa ttttattcat
      1390       1400       1410       1420       1430       1440
aaattctggc caagtcttgt gcatacagat ggattcattc aatcattccg aacaccacta
      1450       1460       1470       1480       1490       1500
ctgaaagcaa agaaaggaga taaagttaga tcattcttct caatgaatga atatcggaaa
      1510       1520       1530       1540       1550       1560
tgggcagatg ttgaagaagg aggaaaatgg aaaattaaat attataaagg acttggaact
      1570       1580       1590       1600       1610       1620
tcaacttcga atgaagcaag agaatatttc agtgatttag atcatcatac tgttaatttt
      1630       1640       1650       1660       1670       1680
aaatacactg gaacaacaga tgatgatgct attcgaatgg cttttgatag agataagagt
      1690       1700       1710       1720       1730       1740
gacgagagaa aagaatggat cagaagatca gaaaatgaga ttacgaatga agatgatggt
      1750       1760       1770       1780       1790       1800
aaaactgaaa taagttatca agaattcgtt gatgggcaac ttatgcaatt tggaatggtc
      1810       1820       1830       1840       1850       1860
gatttaaaaa gatcaattcc atctctgatt gatggtttga aaccatctca acggaagatt
      1870       1880       1890       1900       1910       1920
ctttggacac ttttgaataa tatggatgaa tcgacagaaa tcaaagtatc tcagttggct
      1930       1940       1950       1960       1970       1980
ggagcagttg cacatcgaca atcatatcat catggagaag aatcactggt cagaacaatc
      1990       2000       2010       2020       2030       2040
attcgaatgg gtcaaacatt ttgtggatct tcgaatcttc cacttcttca accaattgga
      2050       2060       2070       2080       2090       2100
cagttcggaa cacgtcatga aggaggaaat gatgcagctt ctgccagata tatttttact
      2110       2120       2130       2140       2150       2160
gcgctcgctc caacaactcg tttgcttttc ccacaggcgg atgatgatct ccttcaaaaa
      2170       2180       2190       2200       2210       2220
aatgtagaag agggaatggt tgtggaacca acgtggttat gcccaatcgt ccctcttatt
      2230       2240       2250       2260       2270       2280
ctgattaatg gaactgaagg tattggtact ggatggtcaa ctaaaattgc aaatcgaaat
      2290       2300       2310       2320       2330       2340
ccaatcgata ttattgatat gattaggcga aaaattgatt cgatctcgac ggaatatgaa
      2350       2360       2370       2380       2390       2400
ataccgccgt tttatgaaga gttcagagga aaacttgaag tagttacacc cacaaagttt
      2410       2420       2430       2440       2450       2460
atcagcagtg ggaagattca attgatacgg ccagaacgaa agaatgcttc aacattttcc
      2470       2480       2490       2500       2510       2520
attgagattg tggaactacc aattggaatc tggacttcaa aatacaagga gaagctgtcg
      2530       2540       2550       2560       2570       2580
aaaattgtgg agacattacc agttttagag ttttccgaac ggcataccga aaaacgagta
      2590       2600       2610       2620       2630       2640
cattttcgaa taactcttga cagaaagaaa tcgtcacgat ttctacaaaa gagcaactcg
      2650       2660       2670       2680       2690       2700
gatcttctga attatttcaa acttcggaca agcttaacag aaaatcgagt gttgtttgat
      2710       2720       2730       2740       2750       2760
agaaatggag aattgaaaga attcggaaat atttcggaaa tcgctgccga attttttgaa
      2770       2780       2790       2800       2810       2820
gttcgcagag atctttatga aaaacggctg aaaattcaaa aagaggaatg tgaagcaaaa
      2830       2840       2850       2860       2870       2880
ctgatatatg ttgaaaatca gctcaatttc atcgaaatgg tgaccaatgg aactattgag
      2890       2900       2910       2920       2930       2940
atacgatcaa tgggacgtaa tcaattggaa gaaaaacttc aggaaatggg tttcagagtt
      2950       2960       2970       2980       2990       3000
gatcctatgg caactattgc taagaactcc aaaaaagcaa actacggata ccttcttgaa
      3010       3020       3030       3040       3050       3060
atgccggtct cacgactaac ttctgatgaa atgaaaagat tggaagaacg aaaatcacga
      3070       3080       3090       3100       3110       3120
cggagaactg agcttgaagc agctgaatct gcagattgga aatctgtgtg gcgttccgaa
      3130       3140       3150       3160
ttggacaagt tggcagaggc agttggaaac aatagaaaga gttaa 

Last modification date: Oct. 5, 2011