Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: Probable DNA topoisomerase 2


DESCRIPTION:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity).

MISCELLANEOUS:
Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.


STRUCTURE SIMILARITY:
Belongs to the type II topoisomerase family.


CATALYTIC ACTIVITY:
ATP-dependent breakage, passage and rejoining of double-stranded DNA.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSDSDSEFSI EDSPKKKTAP KKEKASPKKK KDDANESMVM TEEDRNVFTS IDKKGGGSKQ
        70         80         90        100        110        120
MAIEDIYQKK SQLEHILLRP DTYIGSVEHT EKTPMWVYNM EESKLEQRDI SYVPGLYKIY
       130        140        150        160        170        180
DEILVNAADN KQRDPKMNTI KITINKEKNE ISVYNNGKGI PVTQHKVEKV YVPELIFGTL
       190        200        210        220        230        240
LTSSNYNDDE KKVTGGRNGY GAKLCNIFST KFTLETSSRD YKSAFKQTWI KNMTRDEEPK
       250        260        270        280        290        300
IVKSTDEDFT KITFSPDLAK FKMKELDDDI CHLMARRAYD VAGSSKGVAV FLNGKRIPIK
       310        320        330        340        350        360
GFEDYVQMYT SQFNNEGEPL KIAYEQVGDR WQVALALSEK GFQQVSFVNS IATTKGGRHV
       370        380        390        400        410        420
DYVADQMVAK FIDSIKRKLT KTSMNIKPFQ IKNHMWVFVN CLIENPTFDS QTKETMTLQQ
       430        440        450        460        470        480
KQFGSTCVLS EKFSKAASSV GITDAVMSWV RFKQMDDLNK KCSKTKTSKL KGIPKLEDAN
       490        500        510        520        530        540
DAGTKNSQQC TLILTEGDSA KTLAVSGLSV VGRDKYGVFP LRGKLLNVRE GNMKQIADNA
       550        560        570        580        590        600
EVNAMIKILG LQYKKKYETE DDFKTLRYGK LMVMADQDQD GSHIKGLVIN FIHHFWPSLI
       610        620        630        640        650        660
QRNFVEEFIT PIVKATKGKE EVSFYSLPEY SEWRMNTDNW KSYKIKYYKG LGTSTSKEAK
       670        680        690        700        710        720
EYFLDMVRHR IRFKYNGADD DNAVDMAFSK KKIEERKDWL SKWMREKKDR KQQGLAEEYL
       730        740        750        760        770        780
YNKDTRFVTF KDFVNRELVL FSNLDNERSI PCLVDGFKPG QRKVLFACFK RADKREVKVA
       790        800        810        820        830        840
QLAGAVAEIS AYHHGEQSLM GTIVNLAQDY VGSNNINLLL PIGQFGTRLQ GGKDSASARY
       850        860        870        880        890        900
IFTQLSPVTR TLFPAHDDNV LRFLYEENQR IEPEWYCPII PMVLVNGAQG IGTGWSTNIP
       910        920        930        940        950        960
NYNPRELVKN IKRLIAGEPQ KALAPWYKNF RGKIIQIDPS RFACYGEVAV LDDNTIEITE
       970        980        990       1000       1010       1020
LPIKQWTQDY KEKVLEGLME SSDKKSPVIV DYKEYHTDTT VKFVVKLSPG KLRELERGQD
      1030       1040       1050       1060       1070       1080
LHQVFKLQAV INTTCMVLFD AAGCLRTYTS PEAITQEFYD SRQEKYVQRK EYLLGVLQAQ
      1090       1100       1110       1120       1130       1140
SKRLTNQARF ILAKINNEIV LENKKKAAIV DVLIKMKFDA DPVKKWKEEQ KLKELRESGE
      1150       1160       1170       1180       1190       1200
IELDEDDLAA VAVEEDEAIS SAAKAVETKL SDYDYLVGMA LIKLSEEEKN KLIKESEEKM
      1210       1220       1230       1240       1250       1260
AEVRVIEKKT WQDLWHEDLD NFVSELDKQE AREKADQDAS IKNAAKKLAA DAKTGRGPKK
      1270       1280       1290       1300       1310       1320
NVCTEVLPSK DGQRIEPMLD AATKAKYEKM SQPKKERVKK EPKEPKEPKK VKKEGQDIKK
      1330       1340       1350       1360       1370       1380
FMSPAAPKTA KKEKSDGFNS DMSEESDVEF DEGIDFDSDD DGVEREDVVS KPKPRTGKGA
      1390       1400       1410       1420       1430       1440
AKAEVIDLSD DDEVPAKKPA PAKKAAPKKK KSEFSDLSGG DSDEEAEKKP STSKKPSPKK
      1450       1460       1470       1480       1490       1500
AAPKTAEPKS KAVTDFFGAS KKNGKKAAGS DDEDDESFVV APREKSGRAR KAPPTYDVDS
      1510       1520
GSDSDQPKKK RGRVVDSDSD    

Encoded by top-2 gene

FULL NAME: TOPoisomerase


Nucleic acid sequence

        10         20         30         40         50         60
atgagcgact ctgatagtga attctctatc gaagattcac ccaagaagaa aaccgcacca
        70         80         90        100        110        120
aagaaggaga aggcgtcacc gaagaaaaag aaagatgatg ccaacgagtc gatggttatg
       130        140        150        160        170        180
actgaagagg accgcaatgt gttcacgtcg atcgacaaaa aaggtggtgg ctcgaaacaa
       190        200        210        220        230        240
atggcgatcg aggatatcta ccaaaagaag tcccaactcg agcacattct tcttcgcccg
       250        260        270        280        290        300
gacacctaca tcggttcggt cgagcatacc gagaagacgc cgatgtgggt ctacaacatg
       310        320        330        340        350        360
gaggagagca agctggagca gcgtgacatc tcatacgtgc cgggactcta caagatttat
       370        380        390        400        410        420
gatgaaattc ttgtgaatgc cgctgacaac aaacagagag atccgaagat gaacacaatc
       430        440        450        460        470        480
aagatcacca tcaataagga gaaaaatgag atctctgtct acaacaatgg caaaggaatc
       490        500        510        520        530        540
ccagtcactc agcacaaagt ggagaaagtc tacgtcccag agctgatttt tggaactctt
       550        560        570        580        590        600
ctaacatctt ctaactacaa tgacgatgag aagaaagtga cgggaggacg caacggatat
       610        620        630        640        650        660
ggagcaaagc tttgcaacat cttctccaca aaattcactc tggagacgtc ttcacgggat
       670        680        690        700        710        720
tacaaaagtg cattcaagca aacgtggatc aaaaacatga cgcgtgatga ggagccgaag
       730        740        750        760        770        780
attgttaaga gcaccgacga agacttcacg aagatcacat tctcgccgga tctggcaaag
       790        800        810        820        830        840
ttcaagatga aggagctgga cgatgacatc tgccatttga tggctcggcg tgcgtatgat
       850        860        870        880        890        900
gtggctggat ccagtaaagg agtcgccgtg ttcctcaatg gaaaacgaat tccaatcaaa
       910        920        930        940        950        960
ggattcgagg actacgtcca aatgtacact tcgcagttca acaatgaagg agaacccctc
       970        980        990       1000       1010       1020
aagatcgcat acgagcaagt tggagatcgt tggcaagtcg ccttggctct ttcggaaaaa
      1030       1040       1050       1060       1070       1080
ggcttccaac aagtgtcatt tgtcaacagt attgctacca caaaaggagg acggcacgtg
      1090       1100       1110       1120       1130       1140
gactacgtgg ctgatcagat ggtcgccaag ttcatcgact cgatcaagcg gaagctcaca
      1150       1160       1170       1180       1190       1200
aagacgtcga tgaatatcaa gccattccag atcaaaaatc acatgtgggt ttttgtgaat
      1210       1220       1230       1240       1250       1260
tgcttgatcg aaaatccgac attcgactcc cagacgaaag agactatgac cctgcagcag
      1270       1280       1290       1300       1310       1320
aagcagttcg gatcgacctg cgtcctcagc gagaagttct ccaaagcggc ttcaagtgtt
      1330       1340       1350       1360       1370       1380
ggaatcaccg atgctgttat gagttgggtt cgcttcaaac aaatggacga cctcaacaaa
      1390       1400       1410       1420       1430       1440
aagtgctcca agacgaagac ttccaagctg aagggcattc caaagcttga agatgccaac
      1450       1460       1470       1480       1490       1500
gacgctggaa ccaaaaattc ccaacaatgc acattaattc tgacggaggg agactcggcc
      1510       1520       1530       1540       1550       1560
aaaacgcttg ctgtttcggg actttcagtc gttggacgcg acaaatatgg agtattccca
      1570       1580       1590       1600       1610       1620
cttcgaggaa aattgctaaa tgtccgagaa ggaaatatga aacaaatcgc cgataatgct
      1630       1640       1650       1660       1670       1680
gaggtcaatg ccatgatcaa aattctggga ctccaataca agaagaagta cgagacagaa
      1690       1700       1710       1720       1730       1740
gatgacttca agactcttcg atacggtaaa ctgatggtca tggctgatca ggatcaagac
      1750       1760       1770       1780       1790       1800
ggttcacaca tcaaaggact cgtgatcaat ttcatccatc acttctggcc ttctctcatt
      1810       1820       1830       1840       1850       1860
cagcggaact tcgtagaaga attcatcact ccaattgtca aagccaccaa aggaaaagaa
      1870       1880       1890       1900       1910       1920
gaagtttcct tctattcgct cccagaatat tctgagtgga gaatgaatac ggataactgg
      1930       1940       1950       1960       1970       1980
aagtcgtaca agatcaagta ctacaaggga ttgggtacat cgacttctaa ggaagctaag
      1990       2000       2010       2020       2030       2040
gaatacttct tggacatggt tcgtcatcgt atccgcttca agtacaatgg agctgatgat
      2050       2060       2070       2080       2090       2100
gataacgctg tcgacatggc tttctcgaag aagaagattg aagagagaaa agactggctc
      2110       2120       2130       2140       2150       2160
tcgaagtgga tgcgggagaa gaaggaccga aagcagcagg gacttgctga agaatatctc
      2170       2180       2190       2200       2210       2220
tacaacaagg acactcgatt cgtcaccttc aaagatttcg tcaatcgtga attggtcctc
      2230       2240       2250       2260       2270       2280
ttctcgaatc tcgacaacga gcgttcaatt ccatgccttg tggatggttt caagccagga
      2290       2300       2310       2320       2330       2340
cagcggaagg ttctcttcgc gtgcttcaag agagcagaca agcgtgaagt caaagtagct
      2350       2360       2370       2380       2390       2400
caattggctg gagctgtcgc tgaaatttct gcttaccatc acggagaaca gtcgcttatg
      2410       2420       2430       2440       2450       2460
ggaacaattg tgaatctcgc tcaagattac gttggctcca acaacatcaa cctgcttctt
      2470       2480       2490       2500       2510       2520
ccaatcggac agtttggtac tcgtctccaa ggtggaaagg acagtgcttc agctcgttac
      2530       2540       2550       2560       2570       2580
atcttcactc aactgtcgcc agtcactcgt acactcttcc cggctcacga tgacaatgtc
      2590       2600       2610       2620       2630       2640
cttcgtttcc tttatgaaga aaatcagcgt attgagccag aatggtattg cccgattatt
      2650       2660       2670       2680       2690       2700
ccaatggtac tcgtcaatgg agctcaaggc atcggtactg gatggtccac gaacattcct
      2710       2720       2730       2740       2750       2760
aattacaatc cacgtgaact ggtcaagaac atcaagcgtc ttatcgccgg cgagccacag
      2770       2780       2790       2800       2810       2820
aaagccttag ctccatggta caagaacttc cgcggaaaga tcattcaaat cgacccgagt
      2830       2840       2850       2860       2870       2880
cgatttgcat gctatggtga agttgctgtg ctggatgaca acaccattga gatcaccgag
      2890       2900       2910       2920       2930       2940
ttgccaatca aacagtggac tcaagactac aaagagaagg ttttggaagg attgatggag
      2950       2960       2970       2980       2990       3000
agctcggaca agaaatcgcc tgttatcgtc gactacaaag agtatcacac agatacaact
      3010       3020       3030       3040       3050       3060
gtcaagttcg tcgtgaagct ctcgccggga aaacttcgtg aattggagcg cggtcaggat
      3070       3080       3090       3100       3110       3120
cttcatcaag tcttcaagct ccaagctgtc atcaacacta cgtgcatggt acttttcgat
      3130       3140       3150       3160       3170       3180
gctgccggat gtcttcgtac atacacttcg ccagaagcga ttactcaaga gttctacgat
      3190       3200       3210       3220       3230       3240
agtcgccaag agaagtacgt acagagaaag gagtaccttc tcggagttct tcaggctcag
      3250       3260       3270       3280       3290       3300
agcaagcgtc tcactaacca ggctcgtttc atcctcgcca agatcaacaa cgagattgtt
      3310       3320       3330       3340       3350       3360
ctcgagaaca agaagaaggc ggcgattgtc gatgttttga tcaagatgaa gttcgatgct
      3370       3380       3390       3400       3410       3420
gatccagtga agaagtggaa ggaggagcaa aaactcaaag agcttcgtga atctggagag
      3430       3440       3450       3460       3470       3480
atcgagctgg acgaagatga tctagctgct gtcgccgtcg aagaggacga agccatttcc
      3490       3500       3510       3520       3530       3540
tctgctgcga aggccgttga aaccaagcta tcagactacg attaccttgt cggaatggct
      3550       3560       3570       3580       3590       3600
ctcatcaagc tttcggaaga agagaagaat aagctcatca aggaatcgga ggagaagatg
      3610       3620       3630       3640       3650       3660
gctgaggttc gagttatcga gaagaagacc tggcaagatc tttggcatga ggatctggac
      3670       3680       3690       3700       3710       3720
aacttcgtgt ctgagttgga caaacaggag gctcgcgaga aagctgatca agatgccagc
      3730       3740       3750       3760       3770       3780
atcaaaaatg ccgccaaaaa gcttgctgcc gacgcaaaga ccggacgtgg acccaagaag
      3790       3800       3810       3820       3830       3840
aatgtgtgca cggaagtcct tccatccaaa gatggacagc gcattgagcc gatgttggat
      3850       3860       3870       3880       3890       3900
gctgcaacca aggccaaata tgagaagatg tctcagccaa agaaggaacg cgtcaagaaa
      3910       3920       3930       3940       3950       3960
gagccaaagg agccgaaaga accaaagaag gtgaaaaagg aaggccagga cattaaaaag
      3970       3980       3990       4000       4010       4020
ttcatgtctc cagctgctcc gaagactgcg aagaaggaga aaagcgacgg cttcaactct
      4030       4040       4050       4060       4070       4080
gacatgtcag aggaaagtga cgtggagttc gatgaaggaa tcgatttcga ttcggacgat
      4090       4100       4110       4120       4130       4140
gacggtgtgg agcgtgagga tgtcgtctca aagccaaaac ctcgtactgg aaaaggagct
      4150       4160       4170       4180       4190       4200
gcgaaagcgg aagttatcga tttgtcagat gatgatgaag ttcctgcaaa gaagcctgct
      4210       4220       4230       4240       4250       4260
ccagcgaaga aagctgctcc gaagaagaaa aagagcgagt tcagcgatct gtctggcggc
      4270       4280       4290       4300       4310       4320
gacagtgatg aagaagctga gaagaagccg tccaccagca aaaagccgtc tccaaagaag
      4330       4340       4350       4360       4370       4380
gctgctccga agacggccga gcccaagtcg aaggcggtga ccgatttctt tggtgcttca
      4390       4400       4410       4420       4430       4440
aagaagaacg gaaagaaggc cgctggttcc gatgatgaag acgacgaaag cttcgttgtg
      4450       4460       4470       4480       4490       4500
gctccaagag agaagagcgg aagagctcgc aaggcgccac caacttacga cgtggattca
      4510       4520       4530       4540       4550       4560
ggatccgatt cggatcagcc aaagaagaag aggggacgcg tcgtcgactc cgactcggat

taa     

Last modification date: Oct. 2, 2011