Mus musculus L. (mouse) [MMU]

FULL NAME: DNA topoisomerase 2


DESCRIPTION:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks (By similarity).

STRUCTURE SIMILARITY:
Belongs to the type II topoisomerase family.


CATALYTIC ACTIVITY:
ATP-dependent breakage, passage and rejoining of double-stranded DNA.


PROTEIN TYPE(S):
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MELSPLQPVN ENMLMNKKKN EDGKKRLSIE RIYQKKTQLE HILLRPDTYI GSVELVTQQM
        70         80         90        100        110        120
WVYDEDVGIN YREVTFVPGL YKIFDEILVN AADNKQRDPK MSCIRVTIDP ENNVISIWNN
       130        140        150        160        170        180
GKGIPVVEHK VEKIYVPALI FGQLLTSSNY DDDEKKVTGG RNGYGAKLCN IFSTKFTVET
       190        200        210        220        230        240
ASREYKKMFK QTWMDNMGRA GDMELKPFSG EDYTCITFQP DLSKFKMQSL DKDIVALMVR
       250        260        270        280        290        300
RAYDIAGSTK DVKVFLNGNS LPVKGFRSYV DLYLKDKVDE TGNSLKVIHE QVNPRWEVCL
       310        320        330        340        350        360
TMSERGFQQI SFVNSIATSK GGRHVDYVAD QIVSKLVDVV KKKNKGGVAV KAHQVKNHMW
       370        380        390        400        410        420
IFVNALIENP TFDSQTKENM TLQAKSFGST CQLSEKFIKA AIGCGIVESI LNWVKFKAQI
       430        440        450        460        470        480
QLNKKCSAVK HTKIKGIPKL DDANDAGSRN STECTLILTE GDSAKTLAVS GLGVVGRDKY
       490        500        510        520        530        540
GVFPLRGKIL NVREASHKQI MENAEINNII KIVGLQYKKN YEDEDSLKTL RYGKIMIMTD
       550        560        570        580        590        600
QDQDGSHIKG LLINFIHHNW PSLLRHRFLE EFITPIVKVS KNKQEIAFYS LPEFEEWKSS
       610        620        630        640        650        660
TPNHKKWKVK YYKGLGTSTS KEAKEYFADM KRHRIQFKYS GPEDDAAISL AFSKKQVDDR
       670        680        690        700        710        720
KEWLTNFMED RRQRKLLGLP EDYLYGQSTS YLTYNDFINK ELILFSNSDN ERSIPSMVDG
       730        740        750        760        770        780
LKPGQRKVLF TCFKRNDKRE VKVAQLAGSV AEMSSYHHGE MSLMMTIINL AQNFVGSNNL
       790        800        810        820        830        840
NLLQPIGQFG TRLHGGKDSA SPRYIFTMLS PLARLLFPPK DDHTLRFLYD DNQRVEPEWY
       850        860        870        880        890        900
IPIIPMVLIN GAEGIGTGWS CKIPNFDVRE VVNNIRRLLD GEEPLPMLPS YKNFKGTIEE
       910        920        930        940        950        960
LASNQYVING EVAILDSTTI EISELPIRTW TQTYKEQVLE PMLNGTEKTP SLITDYREYH
       970        980        990       1000       1010       1020
TDTTVKFVIK MTEEKLAEAE RVGLHKVFKL QSSLTCNSMV LFDHVGCLKK YDTVLDILRD
      1030       1040       1050       1060       1070       1080
FFELRLKYYG LRKEWLLGML GAESSKLNNQ ARFILEKIDG KIVIENKPKK ELIKVLIQRG
      1090       1100       1110       1120       1130       1140
YDSDPVKAWK EAQQKVPDEE ENEESDTETS TSDSAAEAGP TFNYLLDMPL WYLTKEKKDE
      1150       1160       1170       1180       1190       1200
LCKQRNEKEQ ELNTLKQKSP SDLWKEDLAV FIEELEVVEA KEKQDEQVGL PGKAGKAKGK
      1210       1220       1230       1240       1250       1260
KAQMCADVLP SPRGKRVIPQ VTVEMKAEAE KKIRKKIKSE NVEGTPAEDG AEPGSLRQRI
      1270       1280       1290       1300       1310       1320
EKKQKKEPGA KKQTTLPFKP VKKGRKKNPW SDSESDVSSN ESNVDVPPRQ KEQRSAAAKA
      1330       1340       1350       1360       1370       1380
KFTVDLDSDE DFSGLDEKDE DEDFLPLDAT PPKAKIPPKN TKKALKTQGS SMSVVDLESD
      1390       1400       1410       1420       1430       1440
VKDSVPASPG VPAADFPAET EQSKPSKKTV GVKKTATKSQ SSVSTAGTKK RAAPKGTKSD
      1450       1460       1470       1480       1490       1500
SALSARVSEK PAPAKAKNSR KRKPSSSDSS DSDFERAISK GATSKKAKGE EQDFPVDLED
      1510       1520
TIAPRAKSDR ARKPIKYLEE SDDDDDLF   

Encoded by Top2a gene

FULL NAME: topoisomerase (DNA) II alpha


OTHER NAME(S):
Top-2


Nucleic acid sequence

        10         20         30         40         50         60
atggagttgt caccgctgca gcctgtaaat gaaaatatgc taatgaacaa aaagaagaat
        70         80         90        100        110        120
gaagatggca agaaaagatt gtctattgaa agaatctatc agaaaaaaac acaactggaa
       130        140        150        160        170        180
catatactgc tccgcccaga tacctacatt ggctctgtgg agttagtgac ccagcaaatg
       190        200        210        220        230        240
tgggtttacg atgaagatgt tggcattaac tacagggaag tcacttttgt tcctggtttg
       250        260        270        280        290        300
tataaaatct ttgatgagat tctagttaat gctgctgata acaaacaaag ggacccaaaa
       310        320        330        340        350        360
atgtcttgta ttagagtcac aattgatcca gaaaataatg taattagcat ctggaataat
       370        380        390        400        410        420
gggaaaggaa tccctgttgt tgaacacaaa gttgagaaaa tatatgtccc agctctcata
       430        440        450        460        470        480
tttggacaac tcctgacctc cagtaactat gacgacgatg agaagaaagt gacaggtggt
       490        500        510        520        530        540
cgaaatggct atggagctaa actgtgtaac atattcagca ccaaatttac tgtggaaaca
       550        560        570        580        590        600
gccagtagag agtacaagaa aatgttcaaa cagacgtgga tggataacat ggggagagct
       610        620        630        640        650        660
ggtgacatgg aactcaagcc ctttagtgga gaagattata catgtatcac cttccagcct
       670        680        690        700        710        720
gacttatcta agtttaaaat gcaaagcctg gacaaagata ttgttgcact gatggtcaga
       730        740        750        760        770        780
agagcatatg atatcgctgg ctccactaaa gatgtcaaag tctttcttaa tggaaatagt
       790        800        810        820        830        840
ctgccagtga aaggattccg cagttacgtg gatttgtatt tgaaggataa ggtagatgaa
       850        860        870        880        890        900
actgggaatt cactgaaggt gatacatgaa caggtcaatc cccggtggga agtgtgctta
       910        920        930        940        950        960
acaatgagcg agagaggctt ccagcagatt agcttcgtca acagcattgc gacttctaag
       970        980        990       1000       1010       1020
ggcggcagac atgtcgatta tgtagctgat cagattgtga gcaaactcgt tgatgtggtg
      1030       1040       1050       1060       1070       1080
aaaaagaaga acaagggcgg ggttgcagtg aaggctcatc aggtgaaaaa tcacatgtgg
      1090       1100       1110       1120       1130       1140
atttttgtaa atgccttaat tgaaaaccca acctttgact ctcaaacaaa agaaaacatg
      1150       1160       1170       1180       1190       1200
actttacaag ccaagagctt tggatcaaca tgtcaattaa gtgaaaagtt catcaaagct
      1210       1220       1230       1240       1250       1260
gcaattggtt gtggtattgt ggaaagcata ctaaactggg tgaagttcaa ggctcaaatc
      1270       1280       1290       1300       1310       1320
caactgaaca agaagtgttc agctgtaaaa cataccaaaa tcaagggaat ccccaaactt
      1330       1340       1350       1360       1370       1380
gatgatgcca acgatgcagg gagccgaaac tctactgaat gcacacttat cctgactgag
      1390       1400       1410       1420       1430       1440
ggagactcag caaaaactct agccgtttca ggccttggag tggttggaag agacaaatat
      1450       1460       1470       1480       1490       1500
ggggtgttcc ctcttagagg aaagatactc aatgtgcgag aagcctctca taaacagatc
      1510       1520       1530       1540       1550       1560
atggaaaatg ctgaaattaa caatatcatc aagattgtgg gtctccagta caagaaaaac
      1570       1580       1590       1600       1610       1620
tatgaagatg aagattcatt gaaaactctt cgttatggga agatcatgat tatgacagat
      1630       1640       1650       1660       1670       1680
caggaccaag atggttccca catcaaaggc ttgctgatca attttatcca tcacaattgg
      1690       1700       1710       1720       1730       1740
ccatctcttc tgcgacatcg ttttctagaa gaatttatca ctcccattgt aaaggtgtcc
      1750       1760       1770       1780       1790       1800
aaaaataagc aagaaatagc attctatagt cttcccgagt ttgaagaatg gaaaagttcg
      1810       1820       1830       1840       1850       1860
actccgaatc ataaaaagtg gaaagtcaaa tactacaaag gtttgggcac cagcacatca
      1870       1880       1890       1900       1910       1920
aaggaagcta aggaatattt tgcagatatg aaacgacatc gtattcagtt caaatactct
      1930       1940       1950       1960       1970       1980
ggccctgaag atgatgctgc gatcagcctg gcctttagta aaaaacaagt tgatgatcga
      1990       2000       2010       2020       2030       2040
aaggaatggt taactaattt tatggaagac agaagacagc ggaagttact tggccttcct
      2050       2060       2070       2080       2090       2100
gaggattatt tgtatggaca aagcacttcg tacctgacct ataatgactt cataaacaag
      2110       2120       2130       2140       2150       2160
gaactcatcc tcttctccaa ctctgataat gaaaggtcta tcccatccat ggtagacggt
      2170       2180       2190       2200       2210       2220
ttgaaaccag gtcagagaaa ggttttgttt acttgtttca aacggaatga caagcgagaa
      2230       2240       2250       2260       2270       2280
gtgaaggttg cccagttagc tgggtcagtg gcagaaatgt cctcttatca ccatggtgag
      2290       2300       2310       2320       2330       2340
atgtcactga tgatgaccat tatcaatttg gcgcagaatt ttgtgggtag caataatttg
      2350       2360       2370       2380       2390       2400
aaccttttac agcccattgg tcagtttgga accaggctgc atggtggcaa ggactcagct
      2410       2420       2430       2440       2450       2460
agtcctaggt acatctttac aatgctcagc cctttggctc ggttgttgtt tcctccaaaa
      2470       2480       2490       2500       2510       2520
gatgatcaca cattacggtt tctatatgat gacaaccaac gtgttgagcc tgaatggtac
      2530       2540       2550       2560       2570       2580
attcctataa tacccatggt gctgataaat ggtgctgagg gaattggtac tgggtggtcc
      2590       2600       2610       2620       2630       2640
tgcaaaatcc ccaactttga tgtgcgtgaa gttgtgaata atatcagacg gcttctggat
      2650       2660       2670       2680       2690       2700
ggagaggagc ccctacccat gctcccaagt tataagaatt tcaaaggtac tattgaagaa
      2710       2720       2730       2740       2750       2760
ctggcttcaa atcagtatgt gattaatgga gaagtagcta ttctggattc tacaaccatt
      2770       2780       2790       2800       2810       2820
gaaatctcag agcttcccat ccgaacgtgg actcagacat ataaagaaca ggttctagaa
      2830       2840       2850       2860       2870       2880
cccatgttga atggaactga gaagacaccc tctctaataa cagactatag ggaataccat
      2890       2900       2910       2920       2930       2940
acagatacca ctgtgaagtt tgtcataaag atgactgaag aaaaactggc agaggcagag
      2950       2960       2970       2980       2990       3000
agagtcggcc tacacaaagt cttcaaactc cagagtagtc tcacttgcaa ctctatggtg
      3010       3020       3030       3040       3050       3060
ctttttgacc atgtaggttg cttaaagaaa tatgacactg tgttggatat tctaagagac
      3070       3080       3090       3100       3110       3120
ttctttgagc tcaggcttaa atattatgga ttaagaaaag aatggcttct aggaatgctt
      3130       3140       3150       3160       3170       3180
ggtgcagaat cttctaaact gaataatcaa gctcgcttta tattagagaa aatagatggc
      3190       3200       3210       3220       3230       3240
aaaatagtca ttgaaaataa acctaaaaaa gaattaatta aagttctgat tcagagaggc
      3250       3260       3270       3280       3290       3300
tacgactctg accctgtgaa agcctggaaa gaagctcagc agaaggttcc agatgaagaa
      3310       3320       3330       3340       3350       3360
gaaaatgaag aaagtgacac tgaaaccagc accagtgact ctgcagccga ggctgggccg
      3370       3380       3390       3400       3410       3420
accttcaact accttctcga catgcccctg tggtatctga ccaaggagaa gaaggatgag
      3430       3440       3450       3460       3470       3480
ctgtgcaaac aaagaaacga gaaggaacaa gagctcaaca cattaaagca aaagagtcca
      3490       3500       3510       3520       3530       3540
tcagatctgt ggaaggaaga tctggctgtt tttattgaag aactggaggt tgtcgaggcc
      3550       3560       3570       3580       3590       3600
aaggaaaagc aggatgaaca agtgggcctt cctggaaagg cggggaaagc aaaggggaag
      3610       3620       3630       3640       3650       3660
aaagcacaga tgtgtgctga cgtcttgcct tctcctcggg gcaaaagagt catcccccaa
      3670       3680       3690       3700       3710       3720
gtgactgtgg agatgaaagc tgaggcagag aagaaaatta ggaagaaaat taagagtgaa
      3730       3740       3750       3760       3770       3780
aacgttgagg gtacccctgc tgaggatggt gcggaaccag gaagcctccg gcaacgaata
      3790       3800       3810       3820       3830       3840
gagaagaagc agaagaaaga gccaggtgca aagaagcaga ctacattgcc gtttaagcct
      3850       3860       3870       3880       3890       3900
gtcaaaaaag ggaggaagaa aaacccctgg tctgactctg agtcagacgt gagcagtaat
      3910       3920       3930       3940       3950       3960
gaaagtaacg ttgatgtccc tcctcgacaa aaagagcaaa gaagtgctgc agcaaaagcc
      3970       3980       3990       4000       4010       4020
aaattcacag tggatttaga ctcggatgaa gatttctcag gtttggatga gaaggatgag
      4030       4040       4050       4060       4070       4080
gatgaagatt tcctcccatt agatgctact ccacctaagg ccaaaatccc cccaaaaaat
      4090       4100       4110       4120       4130       4140
actaaaaaag cactgaagac ccagggaagc tccatgtcgg tagttgatct tgaaagtgat
      4150       4160       4170       4180       4190       4200
gttaaggaca gtgtgccagc ttctccaggc gttcctgctg ctgacttccc agcggaaact
      4210       4220       4230       4240       4250       4260
gaacagtcaa agccatccaa aaagaccgtg ggagtgaaga agacagcaac caaaagccag
      4270       4280       4290       4300       4310       4320
tcttcagtct ccactgctgg taccaaaaag agagctgcgc caaagggaac caaatcagat
      4330       4340       4350       4360       4370       4380
tcagccttga gtgctcgtgt ctcggaaaaa cctgctcctg ccaaagccaa gaacagtcgc
      4390       4400       4410       4420       4430       4440
aaaaggaagc catcttcttc tgatagctct gactctgatt ttgagagagc aatttctaaa
      4450       4460       4470       4480       4490       4500
ggtgccacga gcaagaaagc aaagggagag gaacaggact tccctgtgga cttggaagac
      4510       4520       4530       4540       4550       4560
acgatagctc ctcgagccaa atctgaccgg gcgaggaagc caattaagta cctggaggag
      4570       4580
tccgatgacg atgacgacct cttctga   

Last modification date: Oct. 2, 2011