Drosophila melanogaster Meigen (fruit fly) [DME]

FULL NAME: DNA topoisomerase 2


DESCRIPTION:
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.

MISCELLANEOUS:
Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.


STRUCTURE SIMILARITY:
Belongs to the type II topoisomerase family.


CATALYTIC ACTIVITY:
ATP-dependent breakage, passage and rejoining of double-stranded DNA.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MENGNKALSI EQMYQKKSQL EHILLRPDSY IGSVEFTKEL MWVYDNSQNR MVQKEISFVP
        70         80         90        100        110        120
GLYKIFDEIL VNAADNKQRD KSMNTIKIDI DPERNMVSVW NNGQGIPVTM HKEQKMYVPT
       130        140        150        160        170        180
MIFGHLLTSS NYNDDEKKVT GGRNGYGAKL CNIFSTSFTV ETATREYKKS FKQTWGNNMG
       190        200        210        220        230        240
KASDVQIKDF NGTDYTRITF SPDLAKFKMD RLDEDIVALM SRRAYDVAAS SKGVSVFLNG
       250        260        270        280        290        300
NKLGVRNFKD YIDLHIKNTD DDSGPPIKIV HEVANERWEV ACCPSDRGFQ QVSFVNSIAT
       310        320        330        340        350        360
YKGGRHVDHV VDNLIKQLLE VLKKKNKGGI NIKPFQVRNH LWVFVNCLIE NPTFDSQTKE
       370        380        390        400        410        420
NMTLQQKGFG SKCTLSEKFI NNMSKSGIVE SVLAWAKFKA QNDIAKTGGR KSSKIKGIPK
       430        440        450        460        470        480
LEDANEAGGK NSIKCTLILT EGDSAKSLAV SGLGVIGRDL YGVFPLRGKL LNVREANFKQ
       490        500        510        520        530        540
LSENAEINNL CKIIGLQYKK KYLTEDDLKT LRYGKVMIMT DQDQDGSHIK GLLINFIHTN
       550        560        570        580        590        600
WPELLRLPFL EEFITPIVKA TKKNEELSFY SLPEFEEWKN DTANHHTYNI KYYKGLGTST
       610        620        630        640        650        660
SKEAKEYFQD MDRHRILFKY DGSVDDESIV MAFSKKHIES RKVWLTNHMD EVKRRKELGL
       670        680        690        700        710        720
PERYLYTKGT KSITYADFIN LELVLFSNAD NERSIPSLVD GLKPGQRKVM FTCFKRNDKR
       730        740        750        760        770        780
EVKVAQLSGS VAEMSAYHHG EVSLQMTIVN LAQNFVGANN INLLEPRGQF GTRLSGGKDC
       790        800        810        820        830        840
ASARYIFTIM SPLTRLIYHP LDDPLLDYQV DDGQKIEPLW YLPIIPMVLV NGAEGIGTGW
       850        860        870        880        890        900
STKISNYNPR EIMKNLRKMI NGQEPSVMHP WYKNFLGRME YVSDGRYIQT GNIQILSGNR
       910        920        930        940        950        960
LEISELPVGV WTQNYKENVL EPLSNGTEKV KGIISEYREY HTDTTVRFVI SFAPGEFERI
       970        980        990       1000       1010       1020
HAEEGGFYRV FKLTTTLSTN QMHAFDQNNC LRRFPTAIDI LKEYYKLRRE YYARRRDFLV
      1030       1040       1050       1060       1070       1080
GQLTAQADRL SDQARFILEK CEKKLVVENK QRKAMCDELL KRGYRPDPVK EWQRRIKMED
      1090       1100       1110       1120       1130       1140
AEQADEEDEE EEEAAPSVSS KAKKEKEVDP EKAFKKLTDV KKFDYLLGMS MWMLTEEKKN
      1150       1160       1170       1180       1190       1200
ELLKQRDTKL SELESLRKKT PEMLWLDDLD ALESKLNEVE EKERAEEQGI NLKTAKALKG
      1210       1220       1230       1240       1250       1260
QKSASAKGRK VKSMGGGAGA GDVFPDPDGE PVEFKITEEI IKKMAAAAKV AQAAKEPKKP
      1270       1280       1290       1300       1310       1320
KEPKEPKVKK EPKGKQIKAE PDASGDEVDE FDAMVEGGSK TSPKAKKAVV KKEPGEKKPR
      1330       1340       1350       1360       1370       1380
QKKENGGGLK QSKIDFSKAK AKKSDDDVEE VTPRAERPGR RQASKKIDYS SLFSDEEEDG
      1390       1400       1410       1420       1430       1440
GNVGSDDDGN ASDDDSPKRP AKRGREDESS GGAKKKAPPK KRRAVIESDD DDIEIDEDDD

DDSDFNC     

Encoded by Top2 gene

FULL NAME: Topoisomerase 2


OTHER NAME(S):
CG10223
CHRAC
dCHRAC
Dmel\CG10223
dTopoII
top2
TOP2
TopII
topo II
Topo II
topoII
TopoII
TOPOII


Nucleic acid sequence

        10         20         30         40         50         60
atggagaacg gaaacaaggc cctgtccatc gaacagatgt accagaagaa gtcgcagctg
        70         80         90        100        110        120
gagcacatcc tgctgcgacc cgactcgtac atcggatccg tggagttcac caaggagctg
       130        140        150        160        170        180
atgtgggtgt atgacaactc ccaaaaccgc atggtgcaga aggagatctc tttcgtgccc
       190        200        210        220        230        240
ggcctctaca agatattcga cgagattctt gtgaatgcgg cagataacaa gcagcgagac
       250        260        270        280        290        300
aagagcatga acaccattaa gatcgacatc gatccggagc gcaatatggt gtccgtgtgg
       310        320        330        340        350        360
aacaacggcc agggcattcc ggtgaccatg cacaaggagc agaagatgta cgttccaacg
       370        380        390        400        410        420
atgatctttg gtcatctgct gacctcgtcg aactacaacg acgatgagaa gaaggtcact
       430        440        450        460        470        480
ggcggcagga acggatacgg agcgaagctc tgcaacatat tctccaccag cttcaccgtt
       490        500        510        520        530        540
gagactgcca cgagggaata caagaaaagt ttcaagcaga cttggggaaa caacatggga
       550        560        570        580        590        600
aaagcctccg atgtgcagat caaggacttc aatggcactg actacacacg catcacattc
       610        620        630        640        650        660
agtcccgatc tggccaagtt caagatggac cgtctcgatg aagatattgt ggctctaatg
       670        680        690        700        710        720
tcgcgtcgcg cctacgatgt ggccgcctca tccaagggag tatccgtctt cttaaacggc
       730        740        750        760        770        780
aacaaactgg gtgtacgcaa cttcaaggac tatattgatt tgcacatcaa gaacacggac
       790        800        810        820        830        840
gacgattctg gcccaccgat caagatagtc cacgaggttg ccaacgagcg ttgggaggtg
       850        860        870        880        890        900
gcttgctgtc cttcagatcg aggcttccaa caggtctcgt ttgtcaactc gatagctacc
       910        920        930        940        950        960
tacaagggcg gtcggcatgt ggaccatgtg gtagacaatc tcattaagca gctgctcgag
       970        980        990       1000       1010       1020
gttctgaaga aaaagaacaa aggtggcatc aacatcaagc cattccaggt ccgaaaccat
      1030       1040       1050       1060       1070       1080
ctgtgggttt ttgtcaactg cttgatagag aaccccactt tcgactcgca gaccaaggag
      1090       1100       1110       1120       1130       1140
aacatgactc tgcaacaaaa gggcttcggt tccaagtgta ccctctcgga aaagttcatc
      1150       1160       1170       1180       1190       1200
aacaacatgt ccaagtctgg catcgtggag tctgtgctgg catgggccaa gttcaaggcc
      1210       1220       1230       1240       1250       1260
caaaatgaca ttgccaagac gggcggtcgc aagtcaagca agatcaaggg cattcccaag
      1270       1280       1290       1300       1310       1320
ctggaggacg ctaacgaggc gggtggaaag aactcgatta aatgcaccct catcctcacc
      1330       1340       1350       1360       1370       1380
gagggagact cagccaagtc attggccgta tccggtttgg gcgtgatcgg acgagatctc
      1390       1400       1410       1420       1430       1440
tacggcgtgt tcccgcttag gggtaaactt ctaaatgtgc gggaagctaa tttcaagcag
      1450       1460       1470       1480       1490       1500
ctttcggaga atgccgaaat caacaattta tgcaagataa ttggcttgca atacaaaaag
      1510       1520       1530       1540       1550       1560
aagtacctca ctgaggacga tctaaaaact ctgcgctatg gcaaagtgat gatcatgaca
      1570       1580       1590       1600       1610       1620
gatcaggatc aggatggctc ccacatcaag ggtctcttga tcaactttat ccacaccaat
      1630       1640       1650       1660       1670       1680
tggccagagc ttctgcgtct gcccttcctc gaggagttca ttacaccaat tgtgaaggca
      1690       1700       1710       1720       1730       1740
accaagaaaa acgaggagct gtcattctac tcgctacccg aattcgagga gtggaaaaat
      1750       1760       1770       1780       1790       1800
gatacagcta atcaccatac gtacaatata aagtactata agggtttggg tacttcgacc
      1810       1820       1830       1840       1850       1860
tccaaggagg cgaaagagta ttttcaagac atggatcgcc atcgcatctt atttaagtac
      1870       1880       1890       1900       1910       1920
gatggatcgg tggatgatga gagcattgtt atggccttct ccaagaagca catcgagtcg
      1930       1940       1950       1960       1970       1980
cgaaaggtat ggcttaccaa ccacatggac gaggtgaagc gtcgcaagga gctcggtttg
      1990       2000       2010       2020       2030       2040
ccagagcgat atctctacac caagggcacc aagagcatca cctatgcaga ctttatcaat
      2050       2060       2070       2080       2090       2100
ctggagttgg tgctgttctc gaatgctgac aatgagcgct ccattcctag tctggtggat
      2110       2120       2130       2140       2150       2160
ggcttgaagc cgggtcagcg gaaggtgatg ttcacttgct tcaagaggaa tgacaagcgt
      2170       2180       2190       2200       2210       2220
gaggtgaagg tggcccagct atccggatca gtggcggaga tgtcagccta tcaccacgga
      2230       2240       2250       2260       2270       2280
gaggtatccc tacagatgac aatcgtgaat ctggctcaga attttgtggg tgccaacaac
      2290       2300       2310       2320       2330       2340
attaatctgc ttgagccacg cggtcaattt ggtacccgct tgtcgggagg caaagattgc
      2350       2360       2370       2380       2390       2400
gccagcgctc gttacatttt cactataatg tctcccttga cgcgactcat ctaccatcct
      2410       2420       2430       2440       2450       2460
ttggacgatc cacttttgga ttaccaggtg gacgatggcc aaaagatcga gccactatgg
      2470       2480       2490       2500       2510       2520
tatctgccca tcataccgat ggtattggta aacggagccg agggcatagg aactggatgg
      2530       2540       2550       2560       2570       2580
tccacgaaga tatccaacta caatcctcgt gagattatga aaaatctaag gaagatgata
      2590       2600       2610       2620       2630       2640
aacggacaag agccaagtgt gatgcatccg tggtacaaga actttttagg acgcatggag
      2650       2660       2670       2680       2690       2700
tatgtttcgg atggtcgtta tattcagact ggtaacattc aaattttgtc cggaaaccgt
      2710       2720       2730       2740       2750       2760
ttagaaatca gtgaactccc tgtgggcgta tggacgcaaa actacaagga aaatgtcctg
      2770       2780       2790       2800       2810       2820
gagcctttat caaacggcac cgaaaaggtt aagggtatta tttccgagta cagggagtat
      2830       2840       2850       2860       2870       2880
catacagaca ccaccgttcg ctttgtgatc agtttcgcac ctggagaatt tgagcgcatt
      2890       2900       2910       2920       2930       2940
catgcagaag aaggtggttt ctaccgagtg ttcaaactta ccacgacgct gtccaccaac
      2950       2960       2970       2980       2990       3000
cagatgcatg cgttcgacca gaacaactgt ctgcgacgct tccccaccgc gatcgatatc
      3010       3020       3030       3040       3050       3060
cttaaagagt attacaaact gcgacgagag tactacgccc gccggaggga ctttttggtc
      3070       3080       3090       3100       3110       3120
ggccagctca cggcgcaggc tgatcgcctc agtgatcagg cgcgctttat tctcgaaaag
      3130       3140       3150       3160       3170       3180
tgtgagaaga agctggtggt ggagaacaag cagcgcaagg ccatgtgtga tgagttgttg
      3190       3200       3210       3220       3230       3240
aagcgtggat atcgtcccga tcccgtcaag gagtggcagc gccgcattaa aatggaggat
      3250       3260       3270       3280       3290       3300
gccgagcaag ctgacgaaga ggacgaagaa gaagaggagg cagctcccag tgtcagctca
      3310       3320       3330       3340       3350       3360
aaggctaaga aggaaaagga agtcgatccg gaaaaggcct ttaagaaact aactgatgtc
      3370       3380       3390       3400       3410       3420
aaaaagtttg actaccttct gggtatgtcc atgtggatgt tgacagagga gaagaaaaac
      3430       3440       3450       3460       3470       3480
gagctactca aacagcgcga cactaaactg tccgagttgg aaagtctgcg caagaagacg
      3490       3500       3510       3520       3530       3540
ccggagatgc tttggctgga tgatttggat gccctcgaat cgaagttaaa tgaagtagag
      3550       3560       3570       3580       3590       3600
gagaaggagc gcgcagaaga gcaggggatc aatctcaaga ccgcgaaggc tttgaagggc
      3610       3620       3630       3640       3650       3660
cagaagtcgg cctcagctaa gggcagaaag gttaagtcaa tgggaggcgg agcgggtgcc
      3670       3680       3690       3700       3710       3720
ggagacgtat tcccagatcc cgatggagaa cccgtcgagt ttaagatcac cgaagaaatc
      3730       3740       3750       3760       3770       3780
attaagaaaa tggcagcggc tgccaaggta gctcaggcgg ctaaggagcc gaagaaaccc
      3790       3800       3810       3820       3830       3840
aaagagccca aggagccaaa agtgaagaag gaaccgaagg gcaagcagat taaagccgaa
      3850       3860       3870       3880       3890       3900
cctgatgcca gcggcgatga ggtggacgaa tttgatgcaa tggtcgaggg cggctctaag
      3910       3920       3930       3940       3950       3960
acctcaccca aggccaagaa ggcggttgtc aagaaggagc cgggagaaaa aaagccgcgc
      3970       3980       3990       4000       4010       4020
caaaagaagg agaacggcgg cgggctcaag cagagcaaga ttgacttcag caaggccaag
      4030       4040       4050       4060       4070       4080
gcgaaaaaga gcgacgatga cgtggaggaa gtaactcctc gtgcagagcg tcctggacgt
      4090       4100       4110       4120       4130       4140
cgacaggcca gtaagaagat agactacagc tcgctcttct cggatgagga ggaagacggt
      4150       4160       4170       4180       4190       4200
ggcaacgttg gctctgatga tgatggcaat gccagcgatg atgattcgcc caagcgtcca
      4210       4220       4230       4240       4250       4260
gctaagcgtg gacgagagga tgagagcagt ggaggagcca aaaagaaagc tccgcccaag
      4270       4280       4290       4300       4310       4320
aagaggcgag ctgtaattga aagcgatgat gatgatatcg agattgatga agatgatgat
      4330       4340
gatgattctg attttaattg ttaa   

Last modification date: Oct. 2, 2011