Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA topoisomerase 1 beta


DESCRIPTION:
Evidence at transcript level.

STRUCTURE SIMILARITY:
Belongs to the eukaryotic type I topoisomerase family.


ENZYME REGULATION:
DNA topoisomerase (ATP-hydrolyzing) activity (prediction).


PROTEIN TYPE(S):
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MATEAFVKPV VPNGHDGYED EDEDDIPLVF KRNSNTAATT NRPSPINNAM RNSAIGSTKS
        70         80         90        100        110        120
SPPMRSPLTS PNRSASSSTR SSMMKPALPS SSSVQRSTLK SPLRDDRSVV AKERNGFGKA
       130        140        150        160        170        180
PSVSKSDDED SEDDKPLSAR LKLDSKEVTK QPSSSGRGST QQAVQKSNMR PQGLSDYTKK
       190        200        210        220        230        240
KVLDERAPMS STVQTKTSVG TSSSKPVHIE QKRPLVNNID RNGLKPKTEG HSSQAPAKRP
       250        260        270        280        290        300
LEKGSSSNQS SVKRPKLSEP ARPVKVEQGS HISATQDAKG KNLDASKPLR ANQATVKEDN
       310        320        330        340        350        360
SDGDDHVPIA SRMKSDSSNN KSSSAKPSSS KMIASSSRTI AQKPNKWVKD SKYSKSSKSL
       370        380        390        400        410        420
PSGDGQKKWK TLQHNGVIFP PPYKRHGVKI LFQGKPVDLT PEQEEVATMF AVMRETEYYK
       430        440        450        460        470        480
KPKFRENFWN DWRKLLGKNH MIKSLDDCDF TPIYEWYMQE KETKKQMTAE EKRIVKEEKL
       490        500        510        520        530        540
KQEEKYMWAV LDGVRERIGN FRVEPPGLFR GRGEHPKMGK LKKRIRPCDI TINIGKEAPI
       550        560        570        580        590        600
PECPIPGERW KEVKHDNTVT WLAFWSDPIN PKEFKYVFLA ASSSLKGQSD KEKYEKARKL
       610        620        630        640        650        660
HNHIGSIRAA YTKDFNNKDV TKRQIAVATY LIDKLALRAG NEKDDDEADT VGCCTLKVGN
       670        680        690        700        710        720
VECIPPNKLK FDFLGKDSIQ YVNTVEVEPL VYKAIGQFQA GKSKTDDLFD ELDTSKLNTH
       730        740        750        760        770        780
LKELMAGLTA KVFRTYNASI TLDLMLSKET RDGDVPEKVV VYQQANKEVA IICNHQRTVS
       790        800        810        820        830        840
KSHGAQVEKL AVKIEELREQ IKELNIDLDR AKKGRTPLMG SDGKRKRNLT PEALEKKIMQ
       850        860        870        880        890        900
TQGKIEKMER DMQTKEDMKT VALGTSKINY MDPRITVAWC KRHDVPIEKI FNKSLLAKFA
       910
WAMDVDPEFR FCSSTDE    

Encoded by TOP1BETA gene


OTHER NAME(S):
DNA topoisomerase 1 beta
DNA topoisomerase I alpha
MTE17.2
MTE17_2
TOP1
TOP1ALPHA
TOP1BETA
TOPOISOMERASE 1


Nucleic acid sequence

        10         20         30         40         50         60
atggccactg aggcgtttgt gaaacccgtt gtaccaaatg gtcatgacgg gtacgaagat
        70         80         90        100        110        120
gaagatgaag atgacattcc tttggttttt aagagaaaca gtaatacagc agctacaaca
       130        140        150        160        170        180
aatcgtccta gccctattaa taatgctatg agaaactcgg ctattggttc caccaagtcc
       190        200        210        220        230        240
tcaccaccaa tgaggtctcc tttaacaagc ccgaataggt cagcttcttc atccactaga
       250        260        270        280        290        300
agttcaatga tgaaaccagc attaccgtca tcttcatctg ttcaacgttc gactctgaag
       310        320        330        340        350        360
tcaccgttgc gagatgatag atctgttgtt gctaaggaga ggaacggttt tgggaaagct
       370        380        390        400        410        420
ccttctgtgt ctaaaagtga tgatgaggat tctgaggatg ataaaccatt gagtgctagg
       430        440        450        460        470        480
cttaaattgg attctaaaga ggttaccaaa cagccaagct cttcaggacg tgggagtacg
       490        500        510        520        530        540
cagcaagcag tacaaaagag caacatgagg cctcagggat tgagtgatta cactaaaaag
       550        560        570        580        590        600
aaagttttgg atgagagagc tcccatgtcc tcaacggttc agacaaagac cagtgtgggt
       610        620        630        640        650        660
acatcaagta gcaagcctgt tcatattgaa cagaagagac ctttggttaa caatattgat
       670        680        690        700        710        720
cggaatggtt tgaaacctaa gactgaaggg cacagttctc aggcacctgc taagagacct
       730        740        750        760        770        780
cttgaaaagg ggagttcttc gaatcaatct tctgttaaga ggcccaagct gtcagagcca
       790        800        810        820        830        840
gctagaccag tgaaagtgga gcaaggttca catatttcag ctacgcaaga tgccaaagga
       850        860        870        880        890        900
aagaatctgg atgcatcgaa gccgttgaga gctaaccaag caactgttaa agaagataac
       910        920        930        940        950        960
tcagatggtg atgatcatgt tcctattgcc tcaaggatga agtcagattc ctcaaataat
       970        980        990       1000       1010       1020
aaatcgtctt ccgcaaagcc aagttctagt aaaatgatag cgtcttcatc cagaacaata
      1030       1040       1050       1060       1070       1080
gctcaaaagc ccaacaaatg ggtgaaagat tctaaatatt cgaaatcttc taaatcatta
      1090       1100       1110       1120       1130       1140
ccttctggag atgggcaaaa gaaatggaaa actctacagc acaatggtgt tatttttcca
      1150       1160       1170       1180       1190       1200
cctccatata agcgtcatgg ggttaagata ttgttccagg gaaagcctgt tgacttaact
      1210       1220       1230       1240       1250       1260
cctgaacaag aagaggttgc aactatgttt gcggtgatga gggaaacaga atattataaa
      1270       1280       1290       1300       1310       1320
aaaccaaagt tcagagagaa tttctggaat gattggcgga aactacttgg aaagaaccat
      1330       1340       1350       1360       1370       1380
atgattaaaa gtttagatga ttgtgacttc actcccatat atgaatggta tatgcaggag
      1390       1400       1410       1420       1430       1440
aaggagacaa agaaacaaat gactgcagaa gagaaaagga ttgtgaaaga ggagaaatta
      1450       1460       1470       1480       1490       1500
aagcaggagg agaaatatat gtgggctgtt cttgatggtg tcagggagag gattggaaat
      1510       1520       1530       1540       1550       1560
ttcagagttg agccccctgg gttgtttcga ggccggggag aacatcccaa gatggggaaa
      1570       1580       1590       1600       1610       1620
ctgaaaaagc ggattcgtcc ttgtgatatt acaatcaaca ttggtaaaga ggcgcctatt
      1630       1640       1650       1660       1670       1680
ccagaatgcc ctatccctgg tgaaagatgg aaagaagtta agcatgacaa tactgttacc
      1690       1700       1710       1720       1730       1740
tggcttgctt tttggagtga tcctatcaat ccaaaagagt tcaagtatgt attcttggca
      1750       1760       1770       1780       1790       1800
gctagcagtt cgttgaaggg acaaagcgac aaagagaagt atgagaaagc gaggaagcta
      1810       1820       1830       1840       1850       1860
cataaccata tagggagtat tagagcagca tacaccaaag attttaataa caaggatgta
      1870       1880       1890       1900       1910       1920
acaaagcggc aaatagcagt ggcaacatat ctcatcgata agctagccct tagggctgga
      1930       1940       1950       1960       1970       1980
aatgagaagg atgacgatga ggcagatact gttggttgtt gtacattgaa agtaggaaac
      1990       2000       2010       2020       2030       2040
gtggagtgta ttcctccaaa taagttaaag tttgacttcc ttggtaaaga ctctattcag
      2050       2060       2070       2080       2090       2100
tatgtaaaca cagttgaggt tgagcctctg gtgtataagg caattgggca gttccaagca
      2110       2120       2130       2140       2150       2160
ggaaaatcga aaaccgatga tctctttgat gagctagata cttcaaaact caatactcat
      2170       2180       2190       2200       2210       2220
cttaaggagc ttatggctgg tctcacagcc aaagtattcc gtacgtataa tgcatccatc
      2230       2240       2250       2260       2270       2280
acattggatt taatgttgag taaagaaacc agagacggtg acgttcctga aaaagtggtg
      2290       2300       2310       2320       2330       2340
gtttatcagc aagcgaacaa ggaggttgct atcatttgta accatcaacg tactgtctcg
      2350       2360       2370       2380       2390       2400
aaatctcacg gagcacaagt ggagaagctg gctgtgaaaa tagaagaact aagggagcaa
      2410       2420       2430       2440       2450       2460
ataaaagagc tgaatattga tctcgacagg gctaagaaag gaagaacacc gttaatggga
      2470       2480       2490       2500       2510       2520
tctgatggaa agagaaagag gaacttaaca cctgaagcat tggagaagaa gataatgcaa
      2530       2540       2550       2560       2570       2580
acgcaaggta agatcgagaa gatggaaaga gatatgcaaa caaaagaaga tatgaaaact
      2590       2600       2610       2620       2630       2640
gtcgcattgg gcacatctaa gatcaactac atggatccta ggatcactgt tgcgtggtgc
      2650       2660       2670       2680       2690       2700
aaacgacatg atgtccccat tgagaagata tttaacaagt ctcttctggc taagttcgct
      2710       2720       2730       2740       2750
tgggcaatgg atgttgatcc tgagttcaga ttctgttcaa gtaccgatga ataa

Last modification date: Nov. 17, 2011