Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: DNA topoisomerase 1


DESCRIPTION:
The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another (By similarity).

MISCELLANEOUS:
When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand (By similarity).
Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils (By similarity).


STRUCTURE SIMILARITY:
Belongs to the eukaryotic type I topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSVVSNHHSN GNGNSTVYDT NGNDEIKKEV KDEPMASDSE VPFGELMKRD KKEKKQKKRK
        70         80         90        100        110        120
AESGSDEDDY KPEKRKSSAK NGKKKDVGSD SEDDYKPEKK KSKKNNKKKA QESSEDDDEE
       130        140        150        160        170        180
SEGDVSEEDV KPQIHSDDEL EEEDEAPTTD DEEEQKRKEK ERRKKEKREK KERKEKKRLE
       190        200        210        220        230        240
KENRKIKEED DEDSDDEDDE KAKKKKRKSK GAEKSKPSTS KKDAGGKKEP PKKKVKKEED
       250        260        270        280        290        300
IEDIWEWWKE EKKPAGVKWN SLQHCGPLFA PPYIPLPSHV HFKYGGEKMK LTLETEEIAQ
       310        320        330        340        350        360
FYAGVLDHEY STKEAFNKNF MKDWRKVMTV EERERIHDLK KCDFRAIDAY QKEQREIRKA
       370        380        390        400        410        420
MTKEEKLKIK EEKEAEVKIY GIAIIDGHRQ KVANFRIEPP GVFRGRGGHP KMGLIKKRIM
       430        440        450        460        470        480
PEDVIINCGK DTEIPKPPPG HKWKEVRHDN TVTWLCSWTE SVLGQNKYIM LNPSSKIKGE
       490        500        510        520        530        540
KDFEKYETAR RLKKKIGGIR ERYTDDFKSK EMRVRQRATA LYFIDKLALR AGNEKDVDEA
       550        560        570        580        590        600
ADTVGCCSLR VEHIKLFDSA KLNEDDKKEK EFVVEFDFLG KDSIRYFNRV SVEKRVYKNL
       610        620        630        640        650        660
KIFMEGKAPS DDLFDRLDTA TLNDHLRSLM DGLTVKVFRT YNASITLQEQ LIKLTNPKDN
       670        680        690        700        710        720
VAAKILSYNR ANRQVAILCN HQRAVSKGFD ESMQKLEQKI KDKKKEVKEA EAALKSARGA
       730        740        750        760        770        780
EKEKAQKKYD RLKEQLKKLK ISRTDKDENK QIALGTSKLN YIDPRITVAW CKKFEVPLEK
       790        800
VFTKTHREKF RWAIDMTNSS DEEYVF   

Encoded by top-1 gene

FULL NAME: TOPoisomerase


Nucleic acid sequence

        10         20         30         40         50         60
atgagtgtag tgtcgaatca tcactcgaac ggaaacggca actcaacagt ctacgatacg
        70         80         90        100        110        120
aacggaaacg atgaaatcaa aaaagaggtg aaagatgagc caatggcatc agacagtgaa
       130        140        150        160        170        180
gttccattcg gtgaactgat gaaaagagat aaaaaagaaa agaaacaaaa gaagaggaaa
       190        200        210        220        230        240
gctgaaagtg gatcagatga ggatgattat aagcccgaga agagaaagtc ttcggcgaaa
       250        260        270        280        290        300
aatgggaaaa agaaggatgt tggaagtgat tctgaggatg attataagcc tgaaaagaag
       310        320        330        340        350        360
aaaagcaaga aaaataataa gaaaaaagct caggagagta gtgaggatga tgatgaagaa
       370        380        390        400        410        420
tcagaaggag atgttagtga agaggatgtt aagccacaga tccattccga cgatgaacta
       430        440        450        460        470        480
gaagaagaag acgaagctcc gacgacagat gatgaagagg aacagaagag aaaggagaaa
       490        500        510        520        530        540
gagcgtagaa aaaaggaaaa aagggagaaa aaagagcgaa aagagaagaa acgactggag
       550        560        570        580        590        600
aaggagaatc ggaagattaa ggaagaggac gacgaggatt cggatgatga agatgatgaa
       610        620        630        640        650        660
aaggcgaaga aaaagaaacg aaagtcaaaa ggagctgaaa agagcaagcc aagtacatca
       670        680        690        700        710        720
aagaaagacg ccggcggcaa aaaagagcca ccaaagaaga aagtgaagaa agaggaggat
       730        740        750        760        770        780
atagaagata tatgggaatg gtggaaagag gaaaagaagc ctgcaggtgt taaatggaat
       790        800        810        820        830        840
tcccttcaac actgtggacc actattcgct ccaccataca ttccacttcc atctcatgtt
       850        860        870        880        890        900
catttcaaat atggtggaga gaagatgaag ctgactcttg aaacggaaga aattgctcaa
       910        920        930        940        950        960
ttttatgctg gtgtactgga tcacgagtat tcgacaaaag aggctttcaa caagaatttt
       970        980        990       1000       1010       1020
atgaaagatt ggagaaaagt gatgactgtc gaggaacgtg aacgtataca tgatctgaaa
      1030       1040       1050       1060       1070       1080
aagtgcgatt ttcgagctat cgatgcttat caaaaagagc aacgggaaat tcgcaaagcg
      1090       1100       1110       1120       1130       1140
atgactaaag aggaaaagtt gaagattaaa gaggagaagg aagcggaagt gaagatttat
      1150       1160       1170       1180       1190       1200
ggaattgcaa taattgatgg tcatcggcaa aaggttgcaa atttccgaat tgaacctcca
      1210       1220       1230       1240       1250       1260
ggagtgttcc gtggaagagg tggacatccg aagatgggtc ttatcaagaa gcgtatcatg
      1270       1280       1290       1300       1310       1320
ccagaggatg tcatcataaa ttgcggaaaa gacactgaaa ttccaaaacc accacctggg
      1330       1340       1350       1360       1370       1380
cacaaatgga aagaagtgag acatgacaat actgttacgt ggctgtgctc ttggactgaa
      1390       1400       1410       1420       1430       1440
agtgtgctcg gacagaataa gtacattatg cttaatccat cttcaaagat taaaggagaa
      1450       1460       1470       1480       1490       1500
aaggactttg aaaagtacga aacagcgcgg cgacttaaaa agaagattgg tggaattcgt
      1510       1520       1530       1540       1550       1560
gagcggtata ctgacgattt taagtcgaag gagatgagag ttcgacaacg tgctacggct
      1570       1580       1590       1600       1610       1620
ttgtatttta ttgataagtt ggctcttcgt gctggaaatg agaaggatgt agatgaagct
      1630       1640       1650       1660       1670       1680
gctgatactg ttggttgttg ctcacttcgt gttgagcaca ttaagctctt cgattcggcg
      1690       1700       1710       1720       1730       1740
aaactgaatg aagatgataa gaaggaaaag gagtttgttg tggaattcga ttttcttgga
      1750       1760       1770       1780       1790       1800
aaggattcga ttcgttattt caatcgagtt tctgttgaga agcgagtcta caagaatttg
      1810       1820       1830       1840       1850       1860
aagatattca tggagggaaa agctccgagt gatgatcttt tcgatcgtct cgacactgca
      1870       1880       1890       1900       1910       1920
acactcaatg atcatttgag aagtttgatg gatggtttga cggtaaaagt gttccgtacc
      1930       1940       1950       1960       1970       1980
tataatgctt cgatcacact tcaagagcaa ctgataaagc tgacgaatcc caaggacaat
      1990       2000       2010       2020       2030       2040
gtggcggcaa aaattctgtc atacaatcgt gctaatcggc aggttgcgat cctttgtaac
      2050       2060       2070       2080       2090       2100
catcaacgtg ccgtttcgaa gggattcgat gagtcgatgc aaaagttgga gcaaaagatc
      2110       2120       2130       2140       2150       2160
aaggacaaaa agaaggaggt gaaggaagcc gaagccgcgc tgaagtctgc tcgcggagca
      2170       2180       2190       2200       2210       2220
gaaaaggaga aggcccagaa gaagtacgac agactgaagg agcagttgaa aaagttgaaa
      2230       2240       2250       2260       2270       2280
atctcaagaa ctgataagga tgagaacaaa cagatcgcgt tgggtacttc gaaactcaat
      2290       2300       2310       2320       2330       2340
tatattgatc ctcggatcac tgtcgcctgg tgcaagaagt ttgaggttcc gttggagaag
      2350       2360       2370       2380       2390       2400
gtcttcacca aaactcaccg tgagaaattc cgttgggcca tcgacatgac aaactcgtcg
      2410       2420
gatgaggaat acgtcttcta g   

Last modification date: Oct. 2, 2011