Mus musculus L. (mouse) [MMU]

FULL NAME: DNA topoisomerase I, mitochondrial


DESCRIPTION:
Relieves DNA strain that arise during duplication of mitochondrial DNA (By similarity).

MISCELLANEOUS:
When a topoisomerase transiently breaks a DNA backbone bond, it simultaneously forms a protein-DNA link, in which a tyrosyl oxygen in the enzyme is joined to a DNA phosphorus at one end of the enzyme-severed DNA strand.


STRUCTURE SIMILARITY:
Belongs to the eukaryotic type I topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MLLLWLRALC RRFQHVPCRV PSCQVSRVAK ANRAGWEETS KSSVKWRQLE HKGPYFTPAY
        70         80         90        100        110        120
EPLPDGVHFL YDGKPLKLSL AAEEVATFYG KMLHLECTSK EVFRRNFFSD WRKEMTPEER
       130        140        150        160        170        180
RLITHLDKCD FTEIHKHFLE RAEARRTLPR EQKQKLKEEA EKLQQEFGYC VLDGHREKIG
       190        200        210        220        230        240
NFKTEPPGLF RGRGDHPKMG MLKRRVMPED VVINCSRDSK IPEPPAGHQW KEVRSDNTVM
       250        260        270        280        290        300
WLAAWVEHIQ NSFKYVILNP SSKPKGEMDW QKYEVARRLK GVVDKIRAQY QADWKSPEMK
       310        320        330        340        350        360
KRQLAVALYF IDKLALRTGN EKEEGETADT VGCCSLRVEH IRLHAPAGGQ EHVVELDFLG
       370        380        390        400        410        420
KDSIRYKNHV TVEKLVFQNL QHFMEDKDPR DDLFDALTTS SLNKHLQDLM EGLTAKVFRT
       430        440        450        460        470        480
YNASVTLQEQ LRVLTRAEDS VTCKVLAYNR ANRAVAVLCN HQRAVPKTFE KSMQTLQKKI
       490        500        510        520        530        540
ETKKAQVAEA QVELQKAETD LRMRGDSKPK SFLQKQRRLL KLEEQLARLC AKATDKEENK
       550        560        570        580        590
QVALGTAKLN YLDPRISIAW CKRFGVPVEK IYNKTQRERF AWAFNQAGED FEF

Encoded by Top1mt gene

FULL NAME: DNA topoisomerase 1, mitochondrial


OTHER NAME(S):
2900052H09Rik


Nucleic acid sequence

        10         20         30         40         50         60
atgctgctgc tgtggctcag agccctgtgc cggcgtttcc agcatgtccc ctgccgcgtc
        70         80         90        100        110        120
ccttcctgtc aggtgtcccg ggtcgcgaag gcgaacagag ccgggtggga agaaacgagc
       130        140        150        160        170        180
aagagcagtg tgaagtggag gcagctggag cacaagggcc cgtacttcac cccagcctac
       190        200        210        220        230        240
gagccccttc ctgacggagt gcacttcctc tacgatggca aaccgctgaa gctgagcttg
       250        260        270        280        290        300
gcagcggagg aggtcgctac cttctatggg aaaatgctgc atcttgagtg tacgagcaag
       310        320        330        340        350        360
gaagtctttc ggaggaactt cttcagtgac tggcggaagg agatgacacc tgaggagagg
       370        380        390        400        410        420
aggctcatca cacaccttga caaatgtgac ttcacggaga tccataagca cttcctggaa
       430        440        450        460        470        480
agagctgagg cccgcaggac cctgcccagg gagcagaagc agaagctaaa ggaagaggcc
       490        500        510        520        530        540
gagaaactgc agcaggagtt tggctattgc gttttagatg gccacagaga aaaaataggc
       550        560        570        580        590        600
aatttcaaga cggaaccacc cggcttgttc cgtggccgag gtgaccatcc caagatgggg
       610        620        630        640        650        660
atgttgaaga ggagggtcat gccagaggat gtggtcatta actgcagcag ggattccaag
       670        680        690        700        710        720
atccctgagc ccccagccgg tcaccagtgg aaagaggtac gctcagataa cacagtcatg
       730        740        750        760        770        780
tggctggctg cctgggtgga gcacatccag aactccttca agtatgtcat actgaacccc
       790        800        810        820        830        840
agctccaagc cgaaggggga gatggattgg cagaagtatg aggtagcgcg acgcttgaag
       850        860        870        880        890        900
ggggttgtgg acaagatccg tgcccagtat caggctgact ggaagtcacc agaaatgaag
       910        920        930        940        950        960
aagagacagc tggctgtcgc cctttatttt attgataagc tggcactgcg gacaggcaat
       970        980        990       1000       1010       1020
gagaaggaag agggcgagac ggccgacacc gtgggctgct gctcgctccg tgtggagcac
      1030       1040       1050       1060       1070       1080
atccgactgc acgcgcccgc aggtggccag gagcacgttg tagagctgga cttcttggga
      1090       1100       1110       1120       1130       1140
aaggattcca tccgctataa gaaccacgtg acggtggaga agctcgtgtt ccagaacctt
      1150       1160       1170       1180       1190       1200
cagcacttca tggaagacaa ggaccctagg gatgacctct ttgatgcact gaccacttcc
      1210       1220       1230       1240       1250       1260
agcctgaaca agcacttgca ggacttgatg gaagggctga cagccaaggt gttccggacc
      1270       1280       1290       1300       1310       1320
tacaatgcct ctgtcactct gcaggagcag ctgcgggtgc tgacccgtgc ggaagacagc
      1330       1340       1350       1360       1370       1380
gtaacctgca aagtcttagc ttacaaccgg gcgaaccggg ctgtggcagt cctctgtaac
      1390       1400       1410       1420       1430       1440
catcagagag cagttcccaa gaccttcgag aagtcgatgc agacacttca aaaaaagatt
      1450       1460       1470       1480       1490       1500
gagacaaaga aggcacaggt ggctgaggca caggtagagc tgcagaaagc agagactgac
      1510       1520       1530       1540       1550       1560
ctgagaatga gaggggacag caaacccaaa agtttccttc agaagcagcg acgattgtta
      1570       1580       1590       1600       1610       1620
aagctggaag aacagctggc ccgattgtgc gcgaaggcca cagacaagga ggagaataag
      1630       1640       1650       1660       1670       1680
caggtggccc tgggcaccgc caagctcaac tatctggacc ccaggatcag catcgcctgg
      1690       1700       1710       1720       1730       1740
tgtaagagat ttggagtgcc tgtggagaag atctacaaca agacccagag agagaggttt
      1750       1760       1770       1780
gcctgggcct tcaaccaggc aggtgaagac tttgaattct aa 

Last modification date: Oct. 2, 2011