Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA (cytosine-5)-methyltransferase 1


DESCRIPTION:
Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells. Required for MEA promoter methylation in seeds.

STRUCTURE SIMILARITY:
Belongs to the C5-methyltransferase family.
Contains 2 BAH domains.


CATALYTIC ACTIVITY:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.


RELATED PATHWAY(S):
DNA replication
heterochromatin formation


Amino acids sequence

        10         20         30         40         50         60
MVENGAKAAK RKKRPLPEIQ EVEDVPRTRR PRRAAACTSF KEKSIRVCEK SATIEVKKQQ
        70         80         90        100        110        120
IVEEEFLALR LTALETDVED RPTRRLNDFV LFDSDGVPQP LEMLEIHDIF VSGAILPSDV
       130        140        150        160        170        180
CTDKEKEKGV RCTSFGRVEH WSISGYEDGS PVIWISTELA DYDCRKPAAS YRKVYDYFYE
       190        200        210        220        230        240
KARASVAVYK KLSKSSGGDP DIGLEELLAA VVRSMSSGSK YFSSGAAIID FVISQGDFIY
       250        260        270        280        290        300
NQLAGLDETA KKHESSYVEI PVLVALREKS SKIDKPLQRE RNPSNGVRIK EVSQVAESEA
       310        320        330        340        350        360
LTSDQLVDGT DDDRRYAILL QDEENRKSMQ QPRKNSSSGS ASNMFYIKIN EDEIANDYPL
       370        380        390        400        410        420
PSYYKTSEEE TDELILYDAS YEVQSEHLPH RMLHNWALYN SDLRFISLEL LPMKQCDDID
       430        440        450        460        470        480
VNIFGSGVVT DDNGSWISLN DPDSGSQSHD PDGMCIFLSQ IKEWMIEFGS DDIISISIRT
       490        500        510        520        530        540
DVAWYRLGKP SKLYAPWWKP VLKTARVGIS ILTFLRVESR VARLSFADVT KRLSGLQAND
       550        560        570        580        590        600
KAYISSDPLA VERYLVVHGQ IILQLFAVYP DDNVKRCPFV VGLASKLEDR HHTKWIIKKK
       610        620        630        640        650        660
KISLKELNLN PRAGMAPVAS KRKAMQATTT RLVNRIWGEF YSNYSPEDPL QATAAENGED
       670        680        690        700        710        720
EVEEEGGNGE EEVEEEGENG LTEDTVPEPV EVQKPHTPKK IRGSSGKREI KWDGESLGKT
       730        740        750        760        770        780
SAGEPLYQQA LVGGEMVAVG GAVTLEVDDP DEMPAIYFVE YMFESTDHCK MLHGRFLQRG
       790        800        810        820        830        840
SMTVLGNAAN ERELFLTNEC MTTQLKDIKG VASFEIRSRP WGHQYRKKNI TADKLDWARA
       850        860        870        880        890        900
LERKVKDLPT EYYCKSLYSP ERGGFFSLPL SDIGRSSGFC TSCKIREDEE KRSTIKLNVS
       910        920        930        940        950        960
KTGFFINGIE YSVEDFVYVN PDSIGGLKEG SKTSFKSGRN IGLRAYVVCQ LLEIVPKESR
       970        980        990       1000       1010       1020
KADLGSFDVK VRRFYRPEDV SAEKAYASDI QELYFSQDTV VLPPGALEGK CEVRKKSDMP
      1030       1040       1050       1060       1070       1080
LSREYPISDH IFFCDLFFDT SKGSLKQLPA NMKPKFSTIK DDTLLRKKKG KGVESEIESE
      1090       1100       1110       1120       1130       1140
IVKPVEPPKE IRLATLDIFA GCGGLSHGLK KAGVSDAKWA IEYEEPAGQA FKQNHPESTV
      1150       1160       1170       1180       1190       1200
FVDNCNVILR AIMEKGGDQD DCVSTTEANE LAAKLTEEQK STLPLPGQVD FINGGPPCQG
      1210       1220       1230       1240       1250       1260
FSGMNRFNQS SWSKVQCEMI LAFLSFADYF RPRYFLLENV RTFVSFNKGQ TFQLTLASLL
      1270       1280       1290       1300       1310       1320
EMGYQVRFGI LEAGAYGVSQ SRKRAFIWAA APEEVLPEWP EPMHVFGVPK LKISLSQGLH
      1330       1340       1350       1360       1370       1380
YAAVRSTALG APFRPITVRD TIGDLPSVEN GDSRTNKEYK EVAVSWFQKE IRGNTIALTD
      1390       1400       1410       1420       1430       1440
HICKAMNELN LIRCKLIPTR PGADWHDLPK RKVTLSDGRV EEMIPFCLPN TAERHNGWKG
      1450       1460       1470       1480       1490       1500
LYGRLDWQGN FPTSVTDPQP MGKVGMCFHP EQHRILTVRE CARSQGFPDS YEFAGNINHK
      1510       1520       1530
HRQIGNAVPP PLAFALGRKL KEALHLKKSP QHQP  

Encoded by MET1 gene


OTHER NAME(S):
DDM2
DECREASED DNA METHYLATION 2
DMT01
DMT1
DNA METHYLTRANSFERASE
DNA METHYLTRANSFERASE 01
DNA METHYLTRANSFERASE 1
MET1
MET2
methyltransferase 1
METHYLTRANSFERASE 2
METHYLTRANSFERASE I
METI


Nucleic acid sequence

        10         20         30         40         50         60
atggtggaaa atggggctaa agctgcgaag cgaaagaaga gaccacttcc agagattcaa
        70         80         90        100        110        120
gaggtagaag atgtacctag gacgaggaga ccaaggcgtg ctgcagcgtg taccagtttc
       130        140        150        160        170        180
aaggagaaat ctattcgagt ctgtgagaaa tctgctacta ttgaagtaaa gaaacagcag
       190        200        210        220        230        240
attgtggagg aagagtttct cgcgttacgg ttaacggctc tggaaactga tgttgaagat
       250        260        270        280        290        300
cgtccaacca ggagactgaa tgattttgtt ttgtttgatt cagatggagt tccacaacct
       310        320        330        340        350        360
ctggagatgt tggagattca tgacatattc gtttcaggtg ctatcttacc ttcagatgtg
       370        380        390        400        410        420
tgtactgata aggagaaaga gaagggtgtg aggtgtacat cgtttggacg ggttgagcat
       430        440        450        460        470        480
tggagtatct ctggttatga agatggttcc cctgttattt ggatctcaac ggaattggcg
       490        500        510        520        530        540
gattatgatt gtcgtaaacc tgctgctagc tacaggaagg tttatgatta cttctatgag
       550        560        570        580        590        600
aaagctcgtg cttcagtggc tgtgtataag aaattgtcca agtcatctgg tggggatcct
       610        620        630        640        650        660
gatataggtc ttgaggagtt acttgcggcg gttgtcagat caatgagcag tggaagcaag
       670        680        690        700        710        720
tacttttcta gtggtgcggc aatcatcgat tttgttatat cccagggaga ttttatatat
       730        740        750        760        770        780
aaccaactcg ctggtttgga tgagacagcc aagaaacatg aatcaagcta tgttgagatt
       790        800        810        820        830        840
cctgttcttg tagctctcag agagaagagt agtaagattg acaagcctct gcagagggaa
       850        860        870        880        890        900
agaaacccat ctaatggtgt gaggattaaa gaagtttctc aagttgcgga gagcgaggcc
       910        920        930        940        950        960
ttgacatctg atcaactggt tgatggtact gatgatgaca gaagatatgc tatactctta
       970        980        990       1000       1010       1020
caagacgaag agaataggaa atctatgcaa cagcccagaa aaaacagcag ctcaggttct
      1030       1040       1050       1060       1070       1080
gcttcaaata tgttctacat taagataaat gaagatgaga ttgccaatga ttatcctctc
      1090       1100       1110       1120       1130       1140
ccatcgtact ataagacctc cgaagaagaa acagatgaac ttatacttta tgatgcttcc
      1150       1160       1170       1180       1190       1200
tatgaggttc aatctgaaca cctgcctcac aggatgcttc acaactgggc tctttataac
      1210       1220       1230       1240       1250       1260
tctgatttac gattcatatc actggaactt ctaccgatga aacaatgtga tgatattgat
      1270       1280       1290       1300       1310       1320
gtcaacattt ttgggtcagg tgtggtgact gatgataatg gaagttggat ttctttaaac
      1330       1340       1350       1360       1370       1380
gatcctgaca gcggttctca gtcacacgat cctgatggga tgtgcatatt cctcagtcaa
      1390       1400       1410       1420       1430       1440
attaaagaat ggatgattga gtttgggagc gatgatatta tctccatttc tatacgaaca
      1450       1460       1470       1480       1490       1500
gatgtggcct ggtaccgtct tgggaaacca tcaaaacttt atgccccttg gtggaaacct
      1510       1520       1530       1540       1550       1560
gttctgaaaa cagcaagggt tgggataagc attcttactt ttcttagggt ggaaagtagg
      1570       1580       1590       1600       1610       1620
gttgctaggc tttcatttgc agatgtcaca aaaagactgt ctgggttaca ggcgaatgat
      1630       1640       1650       1660       1670       1680
aaagcttaca tttcttctga ccccttggct gttgagagat atttggtcgt ccatgggcaa
      1690       1700       1710       1720       1730       1740
attattttac agctttttgc agtttatccg gacgacaatg tcaaaaggtg tccatttgtt
      1750       1760       1770       1780       1790       1800
gttggtcttg caagcaaatt ggaggatagg caccacacaa aatggatcat caagaagaag
      1810       1820       1830       1840       1850       1860
aaaatttcgc tgaaggaact gaatctgaat ccaagggcag gcatggcacc agtagcatcg
      1870       1880       1890       1900       1910       1920
aagaggaaag ctatgcaagc aacaacaact cgcctggtca acagaatttg gggagagttt
      1930       1940       1950       1960       1970       1980
tactccaatt actctccaga ggatccattg caggcgactg ctgcagaaaa tggggaggat
      1990       2000       2010       2020       2030       2040
gaggtggaag aggaaggcgg aaatggggag gaagaggttg aagaggaagg tgaaaatggt
      2050       2060       2070       2080       2090       2100
ctcacagagg acactgtacc agaacctgtt gaggttcaga agcctcatac tcctaagaaa
      2110       2120       2130       2140       2150       2160
atccgaggca gttctggaaa aagggaaata aaatgggatg gtgagagtct aggaaaaact
      2170       2180       2190       2200       2210       2220
tctgctggcg agcctctcta tcaacaagcc cttgttggag gggaaatggt ggctgtaggt
      2230       2240       2250       2260       2270       2280
ggcgctgtca ccttggaagt tgatgatcca gatgaaatgc cggccatcta ttttgtggag
      2290       2300       2310       2320       2330       2340
tacatgttcg aaagtacaga tcactgcaaa atgttacatg gtagattctt acaaagagga
      2350       2360       2370       2380       2390       2400
tctatgactg ttctggggaa tgctgctaac gagagggaac tattcctgac taatgaatgc
      2410       2420       2430       2440       2450       2460
atgactacac agctcaagga cattaaagga gtagccagtt ttgagattcg atcaaggcca
      2470       2480       2490       2500       2510       2520
tgggggcatc agtataggaa aaagaacatc actgcggata agcttgactg ggctagagca
      2530       2540       2550       2560       2570       2580
ttagaaagaa aagtaaaaga tttgccaaca gagtattact gcaaaagctt gtactcacct
      2590       2600       2610       2620       2630       2640
gagagagggg gattctttag tcttccacta agtgatattg gtcgcagttc tgggttctgc
      2650       2660       2670       2680       2690       2700
acttcatgta agataaggga ggatgaagag aagaggtcta caattaaact aaatgtttca
      2710       2720       2730       2740       2750       2760
aagacaggct ttttcatcaa tgggattgag tattctgttg aggattttgt ctatgtcaac
      2770       2780       2790       2800       2810       2820
cctgactcta ttggtgggtt gaaggagggt agtaaaactt cttttaagtc tgggcgaaac
      2830       2840       2850       2860       2870       2880
attgggttaa gagcgtatgt tgtttgccaa ttgctggaaa ttgttccaaa ggaatctaga
      2890       2900       2910       2920       2930       2940
aaggctgatt tgggttcctt tgatgttaaa gtgagaaggt tttataggcc tgaggatgtt
      2950       2960       2970       2980       2990       3000
tctgcagaga aggcctatgc ttcagacatc caagaattgt atttcagcca ggacacagtt
      3010       3020       3030       3040       3050       3060
gttctccctc caggtgctct agagggaaaa tgtgaagtaa gaaagaaaag tgatatgccc
      3070       3080       3090       3100       3110       3120
ttatcccgtg aatatccaat atcagaccat attttcttct gtgatctttt ctttgacacc
      3130       3140       3150       3160       3170       3180
tccaaaggtt ctctcaagca gctgcccgcc aatatgaagc caaagttctc tactattaag
      3190       3200       3210       3220       3230       3240
gacgacacac ttttaagaaa gaaaaaggga aagggagtag agagtgaaat tgagtctgag
      3250       3260       3270       3280       3290       3300
attgtcaagc ctgttgagcc acctaaagag attcgtctgg ctactctaga tatttttgct
      3310       3320       3330       3340       3350       3360
ggttgtggtg gcctgtctca tggactgaaa aaggcgggtg tatctgatgc aaagtgggcg
      3370       3380       3390       3400       3410       3420
attgagtatg aagagccagc tgggcaggct tttaaacaaa accatcctga gtcaacagtt
      3430       3440       3450       3460       3470       3480
tttgttgaca actgcaatgt gattcttagg gctataatgg agaaaggtgg agatcaagat
      3490       3500       3510       3520       3530       3540
gattgtgtct ctactacaga ggcaaatgaa ttagcagcta aactaactga ggagcagaag
      3550       3560       3570       3580       3590       3600
agtactctgc cactgcctgg tcaagtggac ttcatcaatg gtggacctcc atgtcaggga
      3610       3620       3630       3640       3650       3660
ttttctggta tgaacaggtt caaccaaagc tcttggagta aagttcagtg tgaaatgata
      3670       3680       3690       3700       3710       3720
ttagcattct tgtcctttgc tgactatttc cggccaaggt attttcttct ggagaacgtg
      3730       3740       3750       3760       3770       3780
aggacctttg tgtcattcaa taaagggcag acatttcagc ttactttggc ttcccttctc
      3790       3800       3810       3820       3830       3840
gaaatgggtt accaggtgag atttggaatc ctggaggccg gtgcatatgg agtatcccaa
      3850       3860       3870       3880       3890       3900
tctcgtaaac gagctttcat ttgggctgct gcaccagaag aagttctccc tgaatggcct
      3910       3920       3930       3940       3950       3960
gagccgatgc atgtctttgg tgttccaaag ttgaaaatct cactatctca aggtttacat
      3970       3980       3990       4000       4010       4020
tatgctgctg ttcgtagtac tgcacttggt gcccctttcc gtccaatcac cgtgagagac
      4030       4040       4050       4060       4070       4080
acaattggtg atcttccatc agtagaaaac ggagactcta ggacaaacaa agagtataaa
      4090       4100       4110       4120       4130       4140
gaggttgcag tctcgtggtt ccaaaaggag ataagaggaa acacgattgc tctcactgat
      4150       4160       4170       4180       4190       4200
catatctgca aggctatgaa tgagcttaac ctcattcgat gcaaattaat cccaactagg
      4210       4220       4230       4240       4250       4260
cctggggctg attggcatga cttgccaaag agaaaggtta cgttatctga tgggcgcgta
      4270       4280       4290       4300       4310       4320
gaagaaatga ttcctttttg tctcccaaac acagctgagc gccacaacgg ttggaaggga
      4330       4340       4350       4360       4370       4380
ctatatggga gattagattg gcaaggaaac tttccgactt ccgtcacgga tcctcagccc
      4390       4400       4410       4420       4430       4440
atgggtaagg ttggaatgtg ctttcatcct gaacagcaca gaatccttac agtccgtgaa
      4450       4460       4470       4480       4490       4500
tgcgcccgat ctcaggggtt tccggatagc tacgagtttg cagggaacat aaatcacaag
      4510       4520       4530       4540       4550       4560
cacaggcaga ttgggaatgc agtccctcca ccattggcat ttgctctagg tcgtaagctc
      4570       4580       4590       4600
aaagaagccc tacatctcaa gaagtctcct caacaccaac cctag 

Last modification date: Oct. 2, 2011