Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]

FULL NAME: DNA (cytosine-5)-methyltransferase CMT2


DESCRIPTION:
May be involved in the CpXpG methylation and in gene silencing (By similarity).

STRUCTURE SIMILARITY:
Belongs to the C5-methyltransferase family.
Contains 1 chromo domain.
Contains 1 BAH domain.


CATALYTIC ACTIVITY:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.


RELATED PATHWAY(S):
DNA replication
heterochromatin formation


Amino acids sequence

        10         20         30         40         50         60
MLSPAKCESE EAQAPLDLHS SSRSEPECLS LVLWCPNPEE AAPSSTRELI KLPDNGEMSL
        70         80         90        100        110        120
RRSTTLNCNS PEENGGEGRV SQRKSSRGKS QPLLMLTNGC QLRRSPRFRA LHANFDNVCS
       130        140        150        160        170        180
VPVTKGGVSQ RKFSRGKSQP LLTLTNGCQL RRSPRFRAVD GNFDSVCSVP VTGKFGSRKR
       190        200        210        220        230        240
KSNSALDKKE SSDSEGLTFK DIAVIAKSLE MEIISECQYK NNVAEGRSRL QDPAKRKVDS
       250        260        270        280        290        300
DTLLYSSINS SKQSLGSNKR MRRSQRFMKG TENEGEENLG KSKGKGMSLA SCSFRRSTRL
       310        320        330        340        350        360
SGTVETGNTE TLNRRKDCGP ALCGAEQVRG TERLVQISKK DHCCEAMKKC EGDGLVSSKQ
       370        380        390        400        410        420
ELLVFPSGCI KKTVNGCRDR TLGKPRSSGL NTDDIHTSSL KISKNDTSNG LTMTTALVEQ
       430        440        450        460        470        480
DAMESLLQGK TSACGAADKG KTREMHVNST VIYLSDSDEP SSIEYLNGDN LTQVESGSAL
       490        500        510        520        530        540
SSGGNEGIVS LDLNNPTKST KRKGKRVTRT AVQEQNKRSI CFFIGEPLSC EEAQERWRWR
       550        560        570        580        590        600
YELKERKSKS RGQQSEDDED KIVANVECHY SQAKVDGHTF SLGDFAYIKG EEEETHVGQI
       610        620        630        640        650        660
VEFFKTTDGE SYFRVQWFYR ATDTIMERQA TNHDKRRLFY STVMNDNPVD CLISKVTVLQ
       670        680        690        700        710        720
VSPRVGLKPN SIKSDYYFDM EYCVEYSTFQ TLRNPKTSEN KLECCADVVP TESTESILKK
       730        740        750        760        770        780
KSFSGELPVL DLYSGCGGMS TGLSLGAKIS GVDVVTKWAV DQNTAACKSL KLNHPNTQVR
       790        800        810        820        830        840
NDAAGDFLQL LKEWDKLCKR YVFNNDQRTD TLRSVNSTKE TSGSSSSSDD DSDSEEYEVE
       850        860        870        880        890        900
KLVDICFGDH DKTGKNGLKF KVHWKGYRSD EDTWELAEEL SNCQDAIREF VTSGFKSKIL
       910        920        930        940        950        960
PLPGRVGVIC GGPPCQGISG YNRHRNVDSP LNDERNQQII VFMDIVEYLK PSYVLMENVV
       970        980        990       1000       1010       1020
DILRMDKGSL GRYALSRLVN MRYQARLGIM TAGCYGLSQF RSRVFMWGAV PNKNLPPFPL
      1030       1040       1050       1060       1070       1080
PTHDVIVRYG LPLEFERNVV AYAEGQPRKL EKALVLKDAI SDLPHVSNDE DREKLPYESL
      1090       1100       1110       1120       1130       1140
PKTDFQRYIR STKRDLTGSA IDNCNKRTML LHDHRPFHIN EDDYARVCQI PKRKGANFRD
      1150       1160       1170       1180       1190       1200
LPGLIVRNNT VCRDPSMEPV ILPSGKPLVP GYVFTFQQGK SKRPFARLWW DETVPTVLTV
      1210       1220       1230       1240       1250       1260
PTCHSQALLH PEQDRVLTIR ESARLQGFPD YFQFCGTIKE RYCQIGNAVA VSVSRALGYS
      1270       1280       1290
LGMAFRGLAR DEHLIKLPQN FSHSTYPQLQ ETIPH  

Encoded by CMT2 gene


OTHER NAME(S):
chromomethylase 2
CMT2
F13C5.190
F13C5_190


Nucleic acid sequence

        10         20         30         40         50         60
atgttatcgc cggccaaatg tgagtcagaa gaggctcaag ctccattgga tctccattct
        70         80         90        100        110        120
tcttctagat ctgaaccgga atgtctctct cttgtcctct ggtgtcccaa tcctgaagaa
       130        140        150        160        170        180
gctgctccgt cctctactag agaactcata aagctccccg acaacggaga gatgagtttg
       190        200        210        220        230        240
aggagatcca cgacgcttaa ttgtaattcg cctgaagaga acggaggaga agggagagtt
       250        260        270        280        290        300
tcgcagagga agtcatctcg tggtaagtca cagccgctgc ttatgttgac gaacggttgt
       310        320        330        340        350        360
cagcttcgga ggtcgccgag atttagggcc ctgcatgcaa atttcgacaa tgtatgctcg
       370        380        390        400        410        420
gttccggtta ccaaaggggg agtttcgcag aggaagttct ctcgtggtaa gtcacagccg
       430        440        450        460        470        480
ctgcttactt tgacgaacgg ttgtcagctt cggaggtcgc cgagatttag ggcggtggat
       490        500        510        520        530        540
ggaaattttg acagtgtatg ctcggttccg gtgactggaa agtttgggtc gaggaagaga
       550        560        570        580        590        600
aagagtaata gtgctctcga taagaaggaa agctcagatt ctgagggact gacattcaaa
       610        620        630        640        650        660
gatatagctg taattgccaa gagcctggag atggaaataa tttccgagtg ccaatataag
       670        680        690        700        710        720
aacaacgttg ctgaaggtag atcaagattg caagatccag ccaagaggaa agttgatagt
       730        740        750        760        770        780
gatacattat tatattcaag catcaatagt tctaaacaga gtctcggaag caataaacga
       790        800        810        820        830        840
atgaggagat ctcaaagatt catgaaggga acggagaatg agggagaaga aaatctaggc
       850        860        870        880        890        900
aagtctaaag gaaaagggat gtctctggca tcttgctcat ttcgaagatc tacaaggcta
       910        920        930        940        950        960
tctggaactg tggaaactgg caacacagaa actttgaaca gaagaaaaga ttgtggcccg
       970        980        990       1000       1010       1020
gcattatgtg gtgcagaaca ggtgagggga actgagaggc tggtgcaaat tagtaagaag
      1030       1040       1050       1060       1070       1080
gatcactgtt gtgaggctat gaagaaatgt gaaggtgatg gcctagtttc atccaagcaa
      1090       1100       1110       1120       1130       1140
gagctattag tttttccttc gggttgcatc aagaaaactg taaatggttg tagggacaga
      1150       1160       1170       1180       1190       1200
acgttaggaa aacccagatc ttctggccta aatacggatg atattcacac tagctctttg
      1210       1220       1230       1240       1250       1260
aaaattagca aaaatgatac tagtaatgga ttaactatga cgactgcgtt agtggagcaa
      1270       1280       1290       1300       1310       1320
gatgcaatgg agtctttact tcagggtaaa actagtgctt gtggtgctgc tgataaggga
      1330       1340       1350       1360       1370       1380
aaaactcggg aaatgcatgt aaattctact gtgatctatc tctctgacag cgatgaaccg
      1390       1400       1410       1420       1430       1440
tcttctattg aatatttaaa tggagataat ttgacacaag tcgaaagtgg atctgccctc
      1450       1460       1470       1480       1490       1500
tcctctgggg gtaatgaggg aatcgtttca ctggatctga ataatccaac gaaatcaacc
      1510       1520       1530       1540       1550       1560
aagagaaagg gtaaacgggt aacccggact gctgtccaag agcagaacaa acgtagtatc
      1570       1580       1590       1600       1610       1620
tgttttttca ttggagagcc actttcttgc gaggaggctc aagaaagatg gcgctggaga
      1630       1640       1650       1660       1670       1680
tatgaactta aggaacgcaa atctaagagt agaggccaac aatcagagga tgacgaagac
      1690       1700       1710       1720       1730       1740
aagattgttg caaatgtaga atgccattat tcgcaagcaa aagtcgacgg tcacaccttt
      1750       1760       1770       1780       1790       1800
agccttggag actttgccta cataaagggt gaagaagaag aaacccatgt tggccagata
      1810       1820       1830       1840       1850       1860
gtagagtttt ttaagacaac agatggagaa agctacttcc gagttcagtg gttttacaga
      1870       1880       1890       1900       1910       1920
gcaacggata caataatgga acggcaggct actaatcatg acaaaaggcg tctcttctat
      1930       1940       1950       1960       1970       1980
tctaccgtaa tgaatgacaa tccagtagat tgtcttattt ctaaagttac tgttttacaa
      1990       2000       2010       2020       2030       2040
gtttcaccta gggtcggatt gaagcccaat tctataaaat ctgactacta ttttgatatg
      2050       2060       2070       2080       2090       2100
gagtattgtg tggagtattc aacatttcaa accttgagaa atcctaaaac gtccgaaaac
      2110       2120       2130       2140       2150       2160
aagcttgagt gttgtgccga tgtggtacct acagaatcca ctgaatctat tttgaaaaag
      2170       2180       2190       2200       2210       2220
aaaagtttta gcggagagct tcctgtgctt gatctttaca gtggttgtgg tggaatgtca
      2230       2240       2250       2260       2270       2280
actgggttaa gtcttggagc caaaatatct ggtgttgatg tcgtgacgaa atgggctgtg
      2290       2300       2310       2320       2330       2340
gaccagaata cggctgcctg taagagcttg aaattgaacc atccaaacac gcaggttagg
      2350       2360       2370       2380       2390       2400
aatgatgctg ctggagactt cctccaactt ttgaaggaat gggataaatt atgcaagcga
      2410       2420       2430       2440       2450       2460
tatgtgttta ataatgatca gagaactgat acattaagat ccgtaaattc aactaaagaa
      2470       2480       2490       2500       2510       2520
actagtggaa gcagctcttc tagtgatgat gattcagatt ctgaggagta cgaagtggaa
      2530       2540       2550       2560       2570       2580
aagctagttg atatatgctt tggtgatcat gacaagacag gaaaaaatgg cctgaagttt
      2590       2600       2610       2620       2630       2640
aaggtgcact ggaaaggata cagaagcgac gaagatacat gggaactagc agaggaattg
      2650       2660       2670       2680       2690       2700
agtaactgtc aagatgccat tcgggagttt gtaactagtg gatttaagtc caagatcttg
      2710       2720       2730       2740       2750       2760
ccacttcctg gtcgtgttgg tgtgatatgt gggggacctc catgccaagg aattagtggc
      2770       2780       2790       2800       2810       2820
tataaccggc acaggaatgt tgattctcca ttgaatgatg aaaggaatca gcaaattata
      2830       2840       2850       2860       2870       2880
gtttttatgg acatagtgga gtatctgaaa ccctcatatg tgttgatgga aaatgttgtt
      2890       2900       2910       2920       2930       2940
gatattctgc gtatggacaa aggttctctt gggcgatacg ctttgagccg tcttgtgaac
      2950       2960       2970       2980       2990       3000
atgagatacc aagcaaggtt aggtatcatg acagctggtt gctatggtct ttcccaattt
      3010       3020       3030       3040       3050       3060
cgatccagag ttttcatgtg gggagctgtt ccaaacaaga acctacctcc gtttccgctt
      3070       3080       3090       3100       3110       3120
ccaacgcatg atgttattgt cagatatggg cttccacttg agttcgagag gaatgtagtt
      3130       3140       3150       3160       3170       3180
gcttatgctg aaggccaacc cagaaaactt gaaaaagctc ttgttctaaa agatgcgata
      3190       3200       3210       3220       3230       3240
tcagatcttc ctcatgtatc aaacgatgaa gaccgggaga aattgcctta tgaaagtctc
      3250       3260       3270       3280       3290       3300
ccaaaaacag attttcagag gtacattaga tcaaccaaac gtgatttgac aggctctgca
      3310       3320       3330       3340       3350       3360
attgataact gtaacaaaag aacaatgcta ctgcatgatc acaggccgtt ccatataaat
      3370       3380       3390       3400       3410       3420
gaagacgact atgcccgagt ttgccaaatc cccaagagga agggagctaa tttcagggat
      3430       3440       3450       3460       3470       3480
cttccggggt taatcgtcag aaacaataca gtatgtcgtg atccatcaat ggaaccggtt
      3490       3500       3510       3520       3530       3540
attctgccat caggaaagcc tttggtacca ggatacgtct ttacttttca gcaagggaaa
      3550       3560       3570       3580       3590       3600
tctaaaagac cgtttgctcg tctttggtgg gatgaaactg ttccaaccgt tctaacagtc
      3610       3620       3630       3640       3650       3660
ccaacatgcc acagtcaggc gttattgcat cctgagcaag atcgagtgct aaccataaga
      3670       3680       3690       3700       3710       3720
gaatctgcac ggcttcaagg tttccctgat tacttccagt tctgtggaac cattaaagaa
      3730       3740       3750       3760       3770       3780
aggtattgtc agattggaaa tgcagtggca gtctcggttt ctcgtgcttt aggttattcg
      3790       3800       3810       3820       3830       3840
cttggtatgg cttttcgtgg tctagcccgc gacgagcatc ttataaaact tccccaaaac
      3850       3860       3870       3880
ttttcgcatt caacttaccc tcagcttcaa gaaaccattc ctcattga 

Last modification date: Oct. 2, 2011