Homo sapiens L. (human) [HSA]

FULL NAME: DNA polymerase subunit gamma-2, mitochondrial


DESCRIPTION:
Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA.

SUBUNIT STRUCTURE:
Heterotrimer composed of a catalytic subunit and an homodimer of accessory subunits.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication


RELATED DISEASE(S):
progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 4 (PEOA4)


Amino acids sequence

        10         20         30         40         50         60
MRSRVAVRAC HKVCRCLLSG FGGRVDAGQP ELLTERSSPK GGHVKSHAEL EGNGEHPEAP
        70         80         90        100        110        120
GSGEGSEALL EICQRRHFLS GSKQQLSRDS LLSGCHPGFG PLGVELRKNL AAEWWTSVVV
       130        140        150        160        170        180
FREQVFPVDA LHHKPGPLLP GDSAFRLVSA ETLREILQDK ELSKEQLVAF LENVLKTSGK
       190        200        210        220        230        240
LRENLLHGAL EHYVNCLDLV NKRLPYGLAQ IGVCFHPVFD TKQIRNGVKS IGEKTEASLV
       250        260        270        280        290        300
WFTPPRTSNQ WLDFWLRHRL QWWRKFAMSP SNFSSSDCQD EEGRKGNKLY YNFPWGKELI
       310        320        330        340        350        360
ETLWNLGDHE LLHMYPGNVS KLHGRDGRKN VVPCVLSVNG DLDRGMLAYL YDSFQLTENS
       370        380        390        400        410        420
FTRKKNLHRK VLKLHPCLAP IKVALDVGRG PTLELRQVCQ GLFNELLENG ISVWPGYLET
       430        440        450        460        470        480
MQSSLEQLYS KYDEMSILFT VLVTETTLEN GLIHLRSRDT TMKEMMHISK LKDFLIKYIS

SAKNV     

Encoded by POLG2 gene

FULL NAME: polymerase (DNA directed), gamma 2, accessory subunit


OTHER NAME(S):
HP55
MTPOLB
PEOA4
POLB
POLG-BETA
POLGB


DESCRIPTION:
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.[provided by RefSeq, Sep 2009]


Nucleic acid sequence

        10         20         30         40         50         60
atgcgctctc gtgtagccgt cagggcctgc cataaggtct gcaggtgcct gttgtctggg
        70         80         90        100        110        120
tttgggggtc gagtagatgc ggggcagccg gagctgttga cggaaaggag tagccccaaa
       130        140        150        160        170        180
ggagggcatg tgaagtcgca cgcggagctc gaggggaacg gcgagcaccc agaagccccc
       190        200        210        220        230        240
gggtctggag agggaagcga ggcgctgtta gagatctgtc agagaaggca tttcctaagt
       250        260        270        280        290        300
ggaagcaagc agcagcttag ccgggattct cttctgagtg ggtgccaccc cggcttcgga
       310        320        330        340        350        360
cccttgggcg tagagttgcg gaagaacctg gccgcagaat ggtggacctc ggtggtggtg
       370        380        390        400        410        420
ttcagggagc aggtattccc ggtggacgcc ctccaccaca aaccaggccc tttgctaccc
       430        440        450        460        470        480
ggggacagtg ccttcaggtt agtttctgca gaaactctac gcgaaatctt gcaagacaaa
       490        500        510        520        530        540
gagctgagta aggaacagct agtagcattt cttgagaacg tattaaaaac ttctgggaaa
       550        560        570        580        590        600
ctacgggaga accttcttca cggtgccttg gaacactatg ttaattgcct ggatctggta
       610        620        630        640        650        660
aacaagaggc taccttatgg ccttgctcag attggagtgt gttttcatcc tgtttttgac
       670        680        690        700        710        720
actaagcaga tacgaaatgg tgttaaaagt attggtgaga agactgaagc ttcgttagta
       730        740        750        760        770        780
tggtttactc ctccgagaac ttcaaaccag tggcttgatt tctggttacg tcatcgactc
       790        800        810        820        830        840
cagtggtgga gaaagtttgc catgagtcca tctaacttca gcagcagtga ctgtcaggat
       850        860        870        880        890        900
gaagaaggcc ggaaaggaaa caaactttac tacaattttc cctggggaaa ggagttaata
       910        920        930        940        950        960
gaaaccctgt ggaacctagg agatcacgaa cttttacaca tgtatcctgg caatgtgtct
       970        980        990       1000       1010       1020
aaattacatg gccgagatgg acgaaaaaat gtggttcctt gtgttctctc tgtaaatggg
      1030       1040       1050       1060       1070       1080
gacctagacc gaggcatgct ggcctacctc tatgattctt tccagctgac agagaactcc
      1090       1100       1110       1120       1130       1140
tttacaagaa agaaaaatct tcatagaaag gtacttaaac ttcacccttg tttagcccct
      1150       1160       1170       1180       1190       1200
attaaggttg ctttggatgt aggaagaggc cccacattgg aactaagaca ggtttgtcaa
      1210       1220       1230       1240       1250       1260
gggctattta atgagttact agaaaatggg atttctgtgt ggcctggtta tttggaaact
      1270       1280       1290       1300       1310       1320
atgcagtcct cattggaaca actttattcg aagtatgatg aaatgagtat tctcttcaca
      1330       1340       1350       1360       1370       1380
gttttggtta ctgaaactac tttggagaat ggattaatac atctgagaag cagagacacc
      1390       1400       1410       1420       1430       1440
acaatgaagg aaatgatgca tatatccaaa ttaaaagact ttttgattaa gtatatatca
      1450
tcagctaaga atgtatag    

Last modification date: Oct. 19, 2011