Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA polymerase gamma


DESCRIPTION:
Involved in the replication of mitochondrial DNA.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-A family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MFYKACPSTL TCSKWIHSII KTKKFLYCRH YSSKSFIDNA PLRINPVGVQ YLSPALQNQV
        70         80         90        100        110        120
FPQQNTQISQ LHLDLAKFHL AKHQLLNKET IKLPSFNFRL PPLQGKTISE HFYNIGLEFA
       130        140        150        160        170        180
EPHLSKAIKF SKIDTPVQPK TWKRQPGWTK YAKDGSISCV PYPDSDCMVF DVEVLYKVSP
       190        200        210        220        230        240
FAVVATAVSE DAWYCWLSPW LLGKSENDRQ LIPSNPKGAL FVGHNVSFDR QRIREEYNIK
       250        260        270        280        290        300
SSRNVFLDTM SLHVATHGMC SRQKPTWFKA RKAYIRSQST ETSEDDDSSS FDDDYQNYLK
       310        320        330        340        350        360
QEPWLAHSSV NSLKDVAKFH CNITLDKSKR DDFASLEKEP ILQKLNELIT YCAHDTYSTH
       370        380        390        400        410        420
QVFKKVFPQF LEVCPHPATF SAMLSLGSVF LPVNHSWTRY INGVEEQYQQ MIQLVDQKLS
       430        440        450        460        470        480
QYAEKAKDLI NTKDTVLKDP WLRQLDWTPC NLYRKLKKAT QEVPVVPKWY KKAYCKTEKR
       490        500        510        520        530        540
AVITAKSRLA PILLRLKWKK HPLAWSDTYG WVFSVERTSK DEIEMLLDQG LVPCSREEDT
       550        560        570        580        590        600
KLDYNNYIFF KVPHKDGPEA RCGSPLSKSY QRYFEEGILQ SDYEVAKKAL EMSASCSYWS
       610        620        630        640        650        660
SARDRIRSQM VVWDKDAELG VPSSVDGFGI ILPCIIPMGT VTRRAVENTW LTASNSKKNR
       670        680        690        700        710        720
LGSELKAMIR APDGYTFVGA DVDSEELWIV ALMGDSQFRL HGATALGMMT LEGKKSEGTD
       730        740        750        760        770        780
LHSKTAAILG VSRDSAKVFN YGRLYGAGLK HTTLLLMQMN PTLKTAEAKE LAKKLYASTK
       790        800        810        820        830        840
GVKSKMSKRL QEMGLPKLTF WSQGTESFVF NKLEAMAQLP SPRTPVLDAG ITQALSSKNL
       850        860        870        880        890        900
SKNSFMTSRV NWAIQSSAVD YLHLLLVSMN HLIKKYYLEA RLSLTVHDEV RYLSSDKDKY
       910        920        930        940        950        960
RVAFALQVAN LWTRAFFCQR LGINELPQSV AFFSSVDIDH VLRKDVKMDC VTPSNKVPIP
       970        980        990       1000       1010
PGEELTIESV LEKLEQSGQS LEPLEQIQCF VDVKATTSAE ITEEDKKNIA YLKAQAFY

Encoded by pog1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgttctaca aagcttgtcc aagtacattg acgtgttcga aatggattca ttcaatcatt
        70         80         90        100        110        120
aaaactaaga aatttctata ttgtcgacat tattcttcta aatcatttat agataatgcc
       130        140        150        160        170        180
ccactgagga ttaacccggt cggtgttcaa tacttatcac ctgctctgca aaatcaagta
       190        200        210        220        230        240
tttccacagc aaaatacaca gatttctcaa ttgcaccttg atctggcaaa attccatttg
       250        260        270        280        290        300
gcgaagcacc aactactgaa taaagaaacg ataaagcttc catcctttaa ctttagactt
       310        320        330        340        350        360
cctcctttgc aaggaaaaac gatttctgaa catttttaca atataggttt agaatttgca
       370        380        390        400        410        420
gagcctcatc tctcaaaggc aataaaattt agcaaaatcg atactccggt tcagccaaaa
       430        440        450        460        470        480
acgtggaagc gccaacctgg ttggaccaaa tacgcgaaag atggaagtat ttcttgtgtt
       490        500        510        520        530        540
ccatacccgg atagtgattg tatggtattt gatgtggaag ttttatacaa ggtgtctcct
       550        560        570        580        590        600
tttgctgtcg tggctaccgc tgtgtctgaa gacgcatggt attgctggct atctccttgg
       610        620        630        640        650        660
ctactgggaa agtccgaaaa tgatcgtcaa ttaatcccat ctaacccaaa gggagctttg
       670        680        690        700        710        720
ttcgtaggac ataacgttag ctttgatcgt cagaggattc gtgaggagta caatatcaaa
       730        740        750        760        770        780
tcttctcgta atgtattcct tgatacaatg tcattgcatg ttgctacaca tggaatgtgc
       790        800        810        820        830        840
tctcgacaga aacctacttg gttcaaagcg agaaaggcgt atattcgttc acaatctact
       850        860        870        880        890        900
gaaacctcgg aagacgacga ctcttcctcg tttgatgacg attatcaaaa ttacttaaaa
       910        920        930        940        950        960
caagaaccat ggttagctca ttcttcagtt aattctttaa aagacgtcgc aaagttccat
       970        980        990       1000       1010       1020
tgcaacatta cacttgataa atcgaaaaga gacgattttg catctttgga aaaggaacca
      1030       1040       1050       1060       1070       1080
attctacaga agttgaatga acttatcaca tattgtgcgc atgatacata ctctacacat
      1090       1100       1110       1120       1130       1140
caagttttca aaaaagtatt ccctcagttt ttggaagtct gtcctcaccc agctactttt
      1150       1160       1170       1180       1190       1200
agtgctatgc tatctctggg tagcgtattt cttccagtta accattcatg gacccgttat
      1210       1220       1230       1240       1250       1260
attaacggcg tagaagaaca gtatcaacaa atgattcaat tagttgatca aaaactgtca
      1270       1280       1290       1300       1310       1320
cagtatgctg aaaaggccaa ggatttaatc aatactaagg ataccgtcct gaaagaccca
      1330       1340       1350       1360       1370       1380
tggctccgtc aacttgattg gacaccatgt aatctttata ggaagttaaa aaaagcaaca
      1390       1400       1410       1420       1430       1440
caagaggtcc cagtggttcc caaatggtac aaaaaggctt attgtaaaac cgaaaaaaga
      1450       1460       1470       1480       1490       1500
gctgtgatta ctgcaaaatc tcgtcttgct cccatacttt tacgtttgaa atggaagaaa
      1510       1520       1530       1540       1550       1560
catcctttag cttggtctga tacctatggt tgggttttct ctgtcgaaag gacatctaaa
      1570       1580       1590       1600       1610       1620
gatgaaatcg aaatgcttct tgatcaaggg cttgtacctt gcagtagaga agaagataca
      1630       1640       1650       1660       1670       1680
aaattggact acaataacta catttttttt aaagtcccgc acaaagatgg gcctgaagct
      1690       1700       1710       1720       1730       1740
agatgtggtt cgccactctc caaatcatat cagcgatact tcgaagaggg tattttacaa
      1750       1760       1770       1780       1790       1800
tcagattatg aagtggctaa aaaggctcta gaaatgagtg catcatgttc ttactggagt
      1810       1820       1830       1840       1850       1860
agtgctcgtg atcgaattcg atcgcaaatg gtagtttggg acaaagatgc tgaacttgga
      1870       1880       1890       1900       1910       1920
gttccgtcct ctgtcgatgg ttttggtatt atattacctt gtattattcc aatgggtact
      1930       1940       1950       1960       1970       1980
gttactcgcc gtgctgttga aaatacatgg ctcactgctt ctaactctaa aaagaatagg
      1990       2000       2010       2020       2030       2040
ctaggatcgg aattgaaagc aatgattcgc gctcccgatg gttacacctt tgttggagca
      2050       2060       2070       2080       2090       2100
gatgtagatt ctgaagagtt atggatagta gcattaatgg gtgattctca gtttaggcta
      2110       2120       2130       2140       2150       2160
cacggggcta ctgcattagg tatgatgact ctggaaggaa aaaaatccga gggcactgat
      2170       2180       2190       2200       2210       2220
ttacattcta agacggctgc catcttaggc gtaagtcgtg attctgcaaa ggtgtttaat
      2230       2240       2250       2260       2270       2280
tacggccgac tatatggcgc tggattaaaa cacactactt tgctattaat gcagatgaat
      2290       2300       2310       2320       2330       2340
cctactttaa agactgccga ggccaaagaa cttgctaaaa aactatatgc atcgactaag
      2350       2360       2370       2380       2390       2400
ggtgtcaaat caaaaatgag caaacgtttg caggaaatgg gattaccaaa gctaacattt
      2410       2420       2430       2440       2450       2460
tggtcgcaag gtacagagag ttttgttttc aacaaacttg aggctatggc acaattacca
      2470       2480       2490       2500       2510       2520
tcccctagaa ctcctgtttt agacgctggg ataacgcaag ctttgagcag taaaaatctg
      2530       2540       2550       2560       2570       2580
agcaaaaact ctttcatgac atctagagtt aattgggcaa ttcaatcatc agctgtggac
      2590       2600       2610       2620       2630       2640
tatcttcatc ttctcttggt atccatgaat catttaatta agaaatatta tctagaagct
      2650       2660       2670       2680       2690       2700
cgcctttctt taactgttca tgacgaggtt cgttatttat catcagataa agataaatat
      2710       2720       2730       2740       2750       2760
cgggttgcat ttgccttaca ggtggctaac ttgtggactc gtgcgttttt ttgtcaacga
      2770       2780       2790       2800       2810       2820
cttggcatca acgagcttcc acaatctgtc gcattttttt cttccgttga tattgaccat
      2830       2840       2850       2860       2870       2880
gtactaagaa aagatgttaa gatggactgt gtaacaccct ctaacaaagt ccccatacct
      2890       2900       2910       2920       2930       2940
cctggagaag agcttactat agagtcagtt ctagaaaaac tcgagcagtc cggtcaatca
      2950       2960       2970       2980       2990       3000
cttgagccac ttgagcaaat tcagtgtttt gtggatgtta aagctactac ttcagcagag
      3010       3020       3030       3040       3050
attacagaag aagacaaaaa aaacattgca tatttaaaag cacaagcatt ttactga

Last modification date: Oct. 2, 2011